Entity Details

Primary name PROS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07225
EntryNamePROS_HUMAN
FullNameVitamin K-dependent protein S
TaxID9606
Evidenceevidence at protein level
Length676
SequenceStatuscomplete
DateCreated1988-04-01
DateModified2021-06-02

Ontological Relatives

GenesPROS1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0002576 platelet degranulation
GO:0004866 endopeptidase inhibitor activity
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005789 endoplasmic reticulum membrane
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0007596 blood coagulation
GO:0030449 regulation of complement activation
GO:0031093 platelet alpha granule lumen
GO:0042730 fibrinolysis
GO:0050900 leukocyte migration
GO:0070062 extracellular exosome
GO:0072562 blood microparticle

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domainDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001791 Laminin G domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR017857 Coagulation factor-like, Gla domain superfamilyFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR033189 Vitamin K-dependent protein SFamilyFamily
IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00055 Drotrecogin alfaDrugbankbiotech
DB00170 MenadioneDrugbanksmall molecule
DB00464 Sodium tetradecyl sulfateDrugbanksmall molecule
DB09332 KappadioneDrugbanksmall molecule