Entity Details

Primary name CATL1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07711
EntryNameCATL1_HUMAN
FullNameProcathepsin L
TaxID9606
Evidenceevidence at protein level
Length333
SequenceStatuscomplete
DateCreated1988-04-01
DateModified2021-06-02

Ontological Relatives

GenesCTSL

GO terms

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GOName
GO:0001968 fibronectin binding
GO:0002224 toll-like receptor signaling pathway
GO:0002250 adaptive immune response
GO:0004197 cysteine-type endopeptidase activity
GO:0005518 collagen binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005764 lysosome
GO:0005771 multivesicular body
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0006955 immune response
GO:0008234 cysteine-type peptidase activity
GO:0016324 apical plasma membrane
GO:0016540 protein autoprocessing
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0019065 receptor-mediated endocytosis of virus by host cell
GO:0019882 antigen processing and presentation
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0022617 extracellular matrix disassembly
GO:0030574 collagen catabolic process
GO:0031638 zymogen activation
GO:0034230 enkephalin processing
GO:0036021 endolysosome lumen
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0042393 histone binding
GO:0042583 chromaffin granule
GO:0043202 lysosomal lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0043373 CD4-positive, alpha-beta T cell lineage commitment
GO:0043394 proteoglycan binding
GO:0045616 regulation of keratinocyte differentiation
GO:0046718 viral entry into host cell
GO:0048002 antigen processing and presentation of peptide antigen
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0060309 elastin catabolic process
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0071682 endocytic vesicle lumen
GO:0071888 macrophage apoptotic process
GO:0097067 cellular response to thyroid hormone stimulus
GO:0097655 serpin family protein binding

Subcellular Location

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Subcellular Location
Apical cell membrane
Cytoplasmic vesicle
Lysosome
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR000169 Cysteine peptidase, cysteine active siteSiteActive site
IPR000668 Peptidase C1A, papain C-terminalDomainDomain
IPR013201 Cathepsin propeptide inhibitor domain (I29)DomainDomain
IPR025660 Cysteine peptidase, histidine active siteSiteActive site
IPR025661 Cysteine peptidase, asparagine active siteSiteActive site
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily
IPR039417 Papain-like cysteine endopeptidaseDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB03661 L-cysteic acidDrugbanksmall molecule
DB07477 FelbinacDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB14962 Trastuzumab deruxtecanDrugbankbiotech

Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
CATL1_HUMANGEM_HUMANBioGRID, IntAct18624398 details
CATL1_HUMANRELB_HUMANBioGRID, IntAct21988832 details
CATL1_HUMANBT3A3_HUMANBioGRID, IntAct21988832 details
CATL1_HUMANPP1G_HUMANBioGRID, IntAct21382349 details
CATL1_HUMANCREL2_HUMANMINT21900206 details
CATL1_HUMANEED_HUMANBioGRID, MINT21900206 details
CATL1_HUMANSGTA_HUMANBioGRID, IntAct25416956 details
CATL1_HUMANCYTA_HUMANBioGRID, HPRD12921779 9585570 details
CATL1_HUMANRXRA_HUMANBioGRID, HPRD9837884 9918848 details
CATL1_HUMANSPB3_HUMANBioGRID, HPRD12949073 9548757 details
CATL1_HUMANBAG6_HUMANBioGRID21900206 details
CATL1_HUMANMCPH1_HUMANBioGRID29150431 details
CATL1_HUMANCYTF_HUMANBioGRID, HPRD, IntAct28514442 9632704 9733783 details
CATL1_HUMANH32_HUMANBioGRID21326229 details
CATL1_HUMANSLPI_HUMANHPRD11435427 details
CATL1_HUMANCATL1_HUMANHPRD9585570 details
CATL1_HUMANCUX1_HUMANHPRD15099520 details
CATL1_HUMANCOIA1_HUMANHPRD10716919 details
CATL1_HUMANIBP3_HUMANHPRD11801256 details
CATL1_HUMANIL8_HUMANHPRD12818188 details
CATL1_HUMANCD7_HUMANHPRD8666891 details
CATL1_HUMANTHYG_HUMANHPRD1939080 details
CATL1_HUMANUROK_HUMANHPRD1551416 details
CATL1_HUMANKNG1_HUMANHPRD11517935 details
CATL1_HUMANCYTB_HUMANHPRD11514663 details
CATL1_HUMANCATC_HUMANHPRD11327826 details
CATL1_HUMANCYTC_HUMANHPRD10428479 details
CATL1_HUMANSPB13_HUMANHPRD12504904 12809493 details
CATL1_HUMANARSA_HUMANHPRD11777924 details
CATL1_HUMANHG2A_HUMANHPRD10022822 details
CATL1_HUMANGLUC_HUMANHPRD7340337 details