Entity Details

Primary name CD3E_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07766
EntryNameCD3E_HUMAN
FullNameT-cell surface glycoprotein CD3 epsilon chain
TaxID9606
Evidenceevidence at protein level
Length207
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesCD3E

GO terms

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GOName
GO:0001772 immunological synapse
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002250 adaptive immune response
GO:0002669 positive regulation of T cell anergy
GO:0004888 transmembrane signaling receptor activity
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007172 signal complex assembly
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007584 response to nutrient
GO:0009897 external side of plasma membrane
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016358 dendrite development
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0021549 cerebellum development
GO:0030159 signaling receptor complex adaptor activity
GO:0031295 T cell costimulation
GO:0032729 positive regulation of interferon-gamma production
GO:0032743 positive regulation of interleukin-2 production
GO:0032753 positive regulation of interleukin-4 production
GO:0033634 positive regulation of cell-cell adhesion mediated by integrin
GO:0042101 T cell receptor complex
GO:0042102 positive regulation of T cell proliferation
GO:0042105 alpha-beta T cell receptor complex
GO:0042110 T cell activation
GO:0042608 T cell receptor binding
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043197 dendritic spine
GO:0044297 cell body
GO:0045059 positive thymic T cell selection
GO:0045060 negative thymic T cell selection
GO:0045879 negative regulation of smoothened signaling pathway
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0046982 protein heterodimerization activity
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776 regulation of immune response
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050852 T cell receptor signaling pathway
GO:0065003 protein-containing complex assembly
GO:0097190 apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR003110 Phosphorylated immunoreceptor signalling ITAMRepeatRepeat
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015484 CD3 protein, epsilon/gamma/delta subunitFamilyFamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00075 MuromonabDrugbankbiotech
DB06607 CatumaxomabDrugbankbiotech

Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
CD3E_HUMANNCK1_HUMANBioGRID, HPRD, MINT12110186 17617578 18955169 details
CD3E_HUMANNCK2_HUMANBioGRID, HPRD, IntAct, MINT12110186 17617578 32296183 details
CD3E_HUMANES8L1_HUMANBioGRID, MINT17617578 18644376 details
CD3E_HUMANZAP70_HUMANBioGRID, HPRD, MINT11855827 7761456 8366117 8647168 8906806 details
CD3E_HUMANKSYK_HUMANBioGRID, HPRD, MINT7761456 9698567 details
CD3E_HUMANCCR7_HUMANMINT22922463 details
CD3E_HUMANMUC15_HUMANBioGRID, IntAct32296183 details
CD3E_HUMANZFPL1_HUMANBioGRID, IntAct32296183 details
CD3E_HUMANPMYT1_HUMANBioGRID, IntAct32296183 details
CD3E_HUMANBNIP3_HUMANBioGRID, IntAct32296183 details
CD3E_HUMANNUCL_HUMANBioGRID, HPRD11115514 details
CD3E_HUMANRPA34_HUMANBioGRID, HPRD10373416 details
CD3E_HUMANTOP2B_HUMANBioGRID, HPRD8626450 details
CD3E_HUMANSNTA1_HUMANBioGRID15123239 details
CD3E_HUMANCSK_HUMANBioGRID8621646 details
CD3E_HUMANADA33_HUMANBioGRID32296183 details
CD3E_HUMANUBS3A_HUMANBioGRID31659016 details
CD3E_HUMANES8L3_HUMANMINT17617578 details
CD3E_HUMANES8L2_HUMANMINT17617578 details
CD3E_HUMANEPS8_HUMANMINT17617578 details
CD3E_HUMANLCK_HUMANBioGRID, HPRD, MINT11855827 14523017 details
CD3E_HUMANSHC1_HUMANHPRD, MINT11855827 details
CD3E_HUMANCD3G_HUMANBioGRID, HPRD, InnateDB20890284 2138083 9582308 details
CD3E_HUMANCD3D_HUMANHPRD, InnateDB20890284 9485181 9582308 details
CD3E_HUMANCD3Z_HUMANBioGRID, IntAct14523017 25241761 details
CD3E_HUMANNCTR1_HUMANIntAct9625766 details
CD3E_HUMANP85A_HUMANBioGRID, HPRD11689561 11855827 19190244 9312149 details
CD3E_HUMANJAK3_HUMANBioGRID11349123 details
CD3E_HUMANLAT_HUMANBioGRID14523017 details
CD3E_HUMANCD38_HUMANBioGRID14523017 details
CD3E_HUMANP85B_HUMANBioGRID19190244 details
CD3E_HUMANU119A_HUMANHPRD14757743 details
CD3E_HUMANTRAT1_HUMANHPRD9687533 details
CD3E_HUMANCD79B_HUMANHPRD7541024 details