Entity Details

Primary name FA7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08709
EntryNameFA7_HUMAN
FullNameCoagulation factor VII
TaxID9606
Evidenceevidence at protein level
Length466
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesF7

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0004252 serine-type endopeptidase activity
GO:0005102 signaling receptor binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0007596 blood coagulation
GO:0007598 blood coagulation, extrinsic pathway
GO:0007623 circadian rhythm
GO:0008236 serine-type peptidase activity
GO:0010037 response to carbon dioxide
GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0016485 protein processing
GO:0030194 positive regulation of blood coagulation
GO:0030335 positive regulation of cell migration
GO:0031100 animal organ regeneration
GO:0031982 vesicle
GO:0032355 response to estradiol
GO:0032571 response to vitamin K
GO:0033595 response to genistein
GO:0043627 response to estrogen
GO:0050927 positive regulation of positive chemotaxis
GO:0051897 positive regulation of protein kinase B signaling
GO:0060416 response to growth hormone
GO:0061476 response to anticoagulant
GO:0062023 collagen-containing extracellular matrix
GO:0070723 response to cholesterol
GO:0097068 response to thyroxine
GO:1904400 response to Thyroid stimulating hormone
GO:1904612 response to 2,3,7,8-tetrachlorodibenzodioxine
GO:1905217 response to astaxanthin
GO:1905225 response to thyrotropin-releasing hormone
GO:1905286 serine-type peptidase complex
GO:2000264 negative regulation of blood coagulation, extrinsic pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domainDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/ZFamilyFamily
IPR017857 Coagulation factor-like, Gla domain superfamilyFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR033190 Coagulation factor VIIFamilyFamily
IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyFamilyHomologous superfamily
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00036 Coagulation factor VIIa Recombinant HumanDrugbankbiotech
DB00100 Coagulation Factor IX (Recombinant)Drugbankbiotech
DB04590 (2R)-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO){5-ETHOXY-2-FLUORO-3-[(3R)-TETRAHYDROFURAN-3-YLOXY]PHENYL}ACETICACIDDrugbanksmall molecule
DB04593 3-({1-[3-CARBAMIMIDOYL-1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-PROPYLCARBAMOYL]-2-METHYL-BUTYLSULFAMOYL}-METHYL)-BENZOIC ACIDDrugbanksmall molecule
DB04606 2-[2-ETHANESULFONYLAMINO-3-(5-PROPOXY-1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIMIDOYL-BENZYLAMIDE)Drugbanksmall molecule
DB04758 2-[2-ETHANESULFONYLAMINO-3-(1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIM IDOYL-BENZYLAMIDE)Drugbanksmall molecule
DB04767 N-[1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-3-METHYLSULFANYL-PROPYL]-3-HYDROXY-2-PROPOXYAMINO-BUTYRAMIDDrugbanksmall molecule
DB06552 rNAPc2Drugbankbiotech
DB07207 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINEDrugbanksmall molecule
DB07247 [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREADrugbanksmall molecule
DB07376 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID)Drugbanksmall molecule
DB08232 [5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acidDrugbanksmall molecule
DB09332 KappadioneDrugbanksmall molecule
DB13151 Anti-inhibitor coagulant complexDrugbankbiotech
DB13152 Coagulation Factor IX HumanDrugbankbiotech
DB13933 Nonacog beta pegolDrugbankbiotech