Entity Details

Primary name HMOX1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09601
EntryNameHMOX1_HUMAN
FullNameHeme oxygenase 1
TaxID9606
Evidenceevidence at protein level
Length288
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesHMOX1

GO terms

Show/Hide Table
GOName
GO:0001525 angiogenesis
GO:0001935 endothelial cell proliferation
GO:0002246 wound healing involved in inflammatory response
GO:0002686 negative regulation of leukocyte migration
GO:0004392 heme oxygenase (decyclizing) activity
GO:0004630 phospholipase D activity
GO:0005198 structural molecule activity
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005901 caveola
GO:0006788 heme oxidation
GO:0006879 cellular iron ion homeostasis
GO:0006979 response to oxidative stress
GO:0007264 small GTPase mediated signal transduction
GO:0007588 excretion
GO:0008217 regulation of blood pressure
GO:0008219 cell death
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0014806 smooth muscle hyperplasia
GO:0016020 membrane
GO:0016239 positive regulation of macroautophagy
GO:0016242 negative regulation of macroautophagy
GO:0019221 cytokine-mediated signaling pathway
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0031670 cellular response to nutrient
GO:0032722 positive regulation of chemokine production
GO:0032764 negative regulation of mast cell cytokine production
GO:0034101 erythrocyte homeostasis
GO:0034383 low-density lipoprotein particle clearance
GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron
GO:0034605 cellular response to heat
GO:0035094 response to nicotine
GO:0035556 intracellular signal transduction
GO:0042167 heme catabolic process
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043305 negative regulation of mast cell degranulation
GO:0043392 negative regulation of DNA binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043627 response to estrogen
GO:0045048 protein insertion into ER membrane
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0055072 iron ion homeostasis
GO:0071243 cellular response to arsenic-containing substance
GO:0071276 cellular response to cadmium ion
GO:0071456 cellular response to hypoxia
GO:0072719 cellular response to cisplatin
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0097421 liver regeneration
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:1904036 negative regulation of epithelial cell apoptotic process
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation

Subcellular Location

Show/Hide Table
Subcellular Location
Endoplasmic reticulum membrane
Microsome

Domains

Show/Hide Table
DomainNameCategoryType
IPR002051 Haem oxygenaseFamilyFamily
IPR016053 Haem oxygenase-likeFamilyFamily
IPR016084 Haem oxygenase-like, multi-helicalFamilyHomologous superfamily
IPR018207 Haem oxygenase conserved siteSiteConserved site

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00163 Vitamin EDrugbanksmall molecule
DB01942 Formic acidDrugbanksmall molecule
DB02073 Biliverdine IX AlphaDrugbanksmall molecule
DB02468 12-PhenylhemeDrugbanksmall molecule
DB03906 2-PhenylhemeDrugbanksmall molecule
DB04803 VerdohemeDrugbanksmall molecule
DB04912 StannsoporfinDrugbanksmall molecule
DB06914 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLEDrugbanksmall molecule
DB07342 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanoneDrugbanksmall molecule
DB09221 PolaprezincDrugbanksmall molecule
DB14001 alpha-Tocopherol succinateDrugbanksmall molecule
DB14002 D-alpha-Tocopherol acetateDrugbanksmall molecule

Interactions

43 interactions

InteractorPartnerSourcesPublicationsLink
HMOX1_HUMANCREB3_HUMANBioGRID, IntAct, MINT21516116 31515488 details
HMOX1_HUMANARLY_HUMANBioGRID, IntAct21988832 details
HMOX1_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
HMOX1_HUMANPOTE1_HUMANbhf-ucl, BioGRID21044950 details
HMOX1_HUMANSTX1A_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANMSMO1_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANCY561_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANELOV6_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANTM14B_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANT4S19_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANERGI3_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANELOV4_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANF174A_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANPDZ1I_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANJAGN1_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANAQP6_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANSC11C_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANTLCD4_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANGP152_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANCOQ9_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANAR13B_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANF210B_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANF209A_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANCPLX4_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANMOT2_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANCD79A_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANCYBR1_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANCRUM3_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANELOV5_HUMANBioGRID, IntAct32296183 details
HMOX1_HUMANPE2R4_HUMANBioGRID, MINT28298427 details
HMOX1_HUMANSMO_HUMANBioGRID, MINT28298427 details
HMOX1_HUMANKASH5_HUMANBioGRID25416956 details
HMOX1_HUMANLMNA_HUMANBioGRID24623722 details
HMOX1_HUMANTMIE_HUMANBioGRID32296183 details
HMOX1_HUMANHMOX1_HUMANBioGRID, HPRD12500973 details
HMOX1_HUMANUFD1_HUMANBioGRID18544348 details
HMOX1_HUMANPSMD2_HUMANBioGRID18544348 details
HMOX1_HUMANSQSTM_HUMANBioGRID31521246 details
HMOX1_HUMANSIAH2_HUMANBioGRID32042051 details
HMOX1_HUMANAKT1_HUMANHPRD15581622 details
HMOX1_HUMANNCPR_HUMANHPRD12626517 details
HMOX1_HUMANBLVRB_HUMANHPRD12626517 details
HMOX1_HUMANNOS1_HUMANHPRD11849436 details