Entity Details

Primary name LOX5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09917
EntryNameLOX5_HUMAN
FullNamePolyunsaturated fatty acid 5-lipoxygenase
TaxID9606
Evidenceevidence at protein level
Length674
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesALOX5

GO terms

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GOName
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002232 leukocyte chemotaxis involved in inflammatory response
GO:0002523 leukocyte migration involved in inflammatory response
GO:0002540 leukotriene production involved in inflammatory response
GO:0004051 arachidonate 5-lipoxygenase activity
GO:0004052 arachidonate 12(S)-lipoxygenase activity
GO:0005506 iron ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005635 nuclear envelope
GO:0005641 nuclear envelope lumen
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006691 leukotriene metabolic process
GO:0006959 humoral immune response
GO:0016363 nuclear matrix
GO:0016525 negative regulation of angiogenesis
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016787 hydrolase activity
GO:0019221 cytokine-mediated signaling pathway
GO:0019369 arachidonic acid metabolic process
GO:0019370 leukotriene biosynthetic process
GO:0019372 lipoxygenase pathway
GO:0030501 positive regulation of bone mineralization
GO:0031965 nuclear membrane
GO:0034440 lipid oxidation
GO:0034774 secretory granule lumen
GO:0035655 interleukin-18-mediated signaling pathway
GO:0036336 dendritic cell migration
GO:0036403 arachidonate 8(S)-lipoxygenase activity
GO:0042593 glucose homeostasis
GO:0042759 long-chain fatty acid biosynthetic process
GO:0043312 neutrophil degranulation
GO:0043651 linoleic acid metabolic process
GO:0045598 regulation of fat cell differentiation
GO:0048471 perinuclear region of cytoplasm
GO:0050727 regulation of inflammatory response
GO:0050728 negative regulation of inflammatory response
GO:0050796 regulation of insulin secretion
GO:0051122 hepoxilin biosynthetic process
GO:0061044 negative regulation of vascular wound healing
GO:0061045 negative regulation of wound healing
GO:0106014 regulation of inflammatory response to wounding
GO:1900015 regulation of cytokine production involved in inflammatory response
GO:1900407 regulation of cellular response to oxidative stress
GO:1901753 leukotriene A4 biosynthetic process
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1903573 negative regulation of response to endoplasmic reticulum stress
GO:1903671 negative regulation of sprouting angiogenesis
GO:1904813 ficolin-1-rich granule lumen
GO:1904999 positive regulation of leukocyte adhesion to arterial endothelial cell
GO:2001301 lipoxin biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus envelope
Nucleus intermembrane space
Nucleus matrix
Nucleus membrane

Domains

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DomainNameCategoryType
IPR000907 LipoxygenaseFamilyFamily
IPR001024 PLAT/LH2 domainDomainDomain
IPR001885 Lipoxygenase, mammalianFamilyFamily
IPR013819 Lipoxygenase, C-terminalDomainDomain
IPR020833 Lipoxygenase, iron binding siteSiteBinding site
IPR020834 Lipoxygenase, conserved siteSiteConserved site
IPR036226 Lipoxigenase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036392 PLAT/LH2 domain superfamilyFamilyHomologous superfamily
IPR042062 Lipoxygenase, vertebrates, PLAT domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00163 Vitamin EDrugbanksmall molecule
DB00179 MasoprocolDrugbanksmall molecule
DB00233 Aminosalicylic acidDrugbanksmall molecule
DB00244 MesalazineDrugbanksmall molecule
DB00471 MontelukastDrugbanksmall molecule
DB00586 DiclofenacDrugbanksmall molecule
DB00711 DiethylcarbamazineDrugbanksmall molecule
DB00744 ZileutonDrugbanksmall molecule
DB00795 SulfasalazineDrugbanksmall molecule
DB00939 Meclofenamic acidDrugbanksmall molecule
DB01014 BalsalazideDrugbanksmall molecule
DB01017 MinocyclineDrugbanksmall molecule
DB01892 HyperforinDrugbanksmall molecule
DB02709 ResveratrolDrugbanksmall molecule
DB04725 LicofeloneDrugbanksmall molecule
DB05431 MLN-977Drugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09285 MorniflumateDrugbanksmall molecule
DB11133 Omega-3 fatty acidsDrugbanksmall molecule
DB11994 DiacereinDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB13168 Omega-6 fatty acidsSwissprotsmall molecule
DB13174 RheinDrugbanksmall molecule
DB14001 alpha-Tocopherol succinateDrugbanksmall molecule
DB14002 D-alpha-Tocopherol acetateDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule

Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
LOX5_HUMANCOTL1_HUMANBioGRID, DIP, HPRD, UniProt10051563 11297527 16924104 19579006 19807693 25034252 details
LOX5_HUMANMAPK2_HUMANBioGRID, HPRD, MINT10779545 11844797 24860872 details
LOX5_HUMANYES_HUMANMINT24860872 details
LOX5_HUMANKAPCA_HUMANMINT24860872 details
LOX5_HUMANHCK_HUMANMINT24860872 details
LOX5_HUMANFGR_HUMANMINT24860872 details
LOX5_HUMANKCC2G_HUMANMINT24860872 details
LOX5_HUMANMEOX1_HUMANBioGRID, IntAct25416956 details
LOX5_HUMANREL_HUMANBioGRID, IntAct25416956 details
LOX5_HUMANHIPL2_HUMANBioGRID, IntAct25416956 25910212 details
LOX5_HUMANNUTM1_HUMANBioGRID, IntAct25416956 31515488 32296183 details
LOX5_HUMANCE57L_HUMANBioGRID, IntAct25416956 25910212 details
LOX5_HUMANSYCE1_HUMANBioGRID, IntAct25416956 25910212 details
LOX5_HUMANCEP63_HUMANBioGRID, IntAct25416956 25910212 31515488 32296183 details
LOX5_HUMANMD1L1_HUMANBioGRID, IntAct25416956 25910212 32296183 details
LOX5_HUMANLCN1_HUMANBioGRID, IntAct32296183 details
LOX5_HUMANTBCD7_HUMANBioGRID, IntAct32296183 details
LOX5_HUMANDHB1_HUMANBioGRID, IntAct32296183 details
LOX5_HUMANOOEP_HUMANBioGRID, IntAct32296183 details
LOX5_HUMANCC174_HUMANBioGRID, IntAct32296183 details
LOX5_HUMANCJ067_HUMANBioGRID, IntAct32296183 details
LOX5_HUMANGATC_HUMANBioGRID, IntAct32296183 details
LOX5_HUMANSPRE1_HUMANIntAct32814053 details
LOX5_HUMANTGFA1_HUMANBioGRID, HPRD10051563 details
LOX5_HUMANGRB2_HUMANBioGRID, HPRD7929073 8585605 details
LOX5_HUMANA4_HUMANBioGRID21832049 details
LOX5_HUMANLTC4S_HUMANBioGRID19233132 details
LOX5_HUMANAL5AP_HUMANBioGRID, HPRD19233132 26327594 26396238 9445303 details
LOX5_HUMANDICER_HUMANBioGRID10051563 19022417 details
LOX5_HUMANPPBT_HUMANBioGRID26210919 details
LOX5_HUMANMEOX2_HUMANBioGRID32296183 details
LOX5_HUMANP85A_HUMANBioGRID21200133 details
LOX5_HUMANTF65_HUMANBioGRID9681993 details
LOX5_HUMANACTB_HUMANHPRD7929073 details