Entity Details

Primary name CCL3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10147
EntryNameCCL3_HUMAN
FullNameC-C motif chemokine 3
TaxID9606
Evidenceevidence at protein level
Length92
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesCCL3

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001649 osteoblast differentiation
GO:0001775 cell activation
GO:0002548 monocyte chemotaxis
GO:0004672 protein kinase activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006887 exocytosis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007010 cytoskeleton organization
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008009 chemokine activity
GO:0008360 regulation of cell shape
GO:0009636 response to toxic substance
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010818 T cell chemotaxis
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0016004 phospholipase activator activity
GO:0016301 kinase activity
GO:0019221 cytokine-mediated signaling pathway
GO:0019722 calcium-mediated signaling
GO:0023052 signaling
GO:0030335 positive regulation of cell migration
GO:0030502 negative regulation of bone mineralization
GO:0030593 neutrophil chemotaxis
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0031726 CCR1 chemokine receptor binding
GO:0031730 CCR5 chemokine receptor binding
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0042056 chemoattractant activity
GO:0042802 identical protein binding
GO:0043308 eosinophil degranulation
GO:0043491 protein kinase B signaling
GO:0043525 positive regulation of neuron apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0043615 astrocyte cell migration
GO:0043922 negative regulation by host of viral transcription
GO:0045671 negative regulation of osteoclast differentiation
GO:0048020 CCR chemokine receptor binding
GO:0048245 eosinophil chemotaxis
GO:0048246 macrophage chemotaxis
GO:0048247 lymphocyte chemotaxis
GO:0050729 positive regulation of inflammatory response
GO:0050795 regulation of behavior
GO:0050850 positive regulation of calcium-mediated signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0051928 positive regulation of calcium ion transport
GO:0051930 regulation of sensory perception of pain
GO:0070098 chemokine-mediated signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070723 response to cholesterol
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071407 cellular response to organic cyclic compound
GO:0071621 granulocyte chemotaxis
GO:0090280 positive regulation of calcium ion import
GO:1903980 positive regulation of microglial cell activation
GO:1904141 positive regulation of microglial cell migration
GO:2000503 positive regulation of natural killer cell chemotaxis

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000827 CC chemokine, conserved siteSiteConserved site
IPR001811 Chemokine interleukin-8-like domainDomainDomain
IPR036048 Chemokine interleukin-8-like superfamilyFamilyHomologous superfamily
IPR039809 Chemokine beta/gamma/deltaFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB05364 ROX-888Drugbanksmall molecule