Entity Details

Primary name SRF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11831
EntryNameSRF_HUMAN
FullNameSerum response factor
TaxID9606
Evidenceevidence at protein level
Length508
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesSRF

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001666 response to hypoxia
GO:0001707 mesoderm formation
GO:0001764 neuron migration
GO:0001829 trophectodermal cell differentiation
GO:0001947 heart looping
GO:0002011 morphogenesis of an epithelial sheet
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007160 cell-matrix adhesion
GO:0007507 heart development
GO:0007616 long-term memory
GO:0008134 transcription factor binding
GO:0008285 negative regulation of cell population proliferation
GO:0008306 associative learning
GO:0009636 response to toxic substance
GO:0009725 response to hormone
GO:0010669 epithelial structure maintenance
GO:0010735 positive regulation of transcription via serum response element binding
GO:0010736 serum response element binding
GO:0021766 hippocampus development
GO:0022028 tangential migration from the subventricular zone to the olfactory bulb
GO:0030036 actin cytoskeleton organization
GO:0030155 regulation of cell adhesion
GO:0030168 platelet activation
GO:0030220 platelet formation
GO:0030336 negative regulation of cell migration
GO:0030878 thyroid gland development
GO:0031175 neuron projection development
GO:0031490 chromatin DNA binding
GO:0033561 regulation of water loss via skin
GO:0034097 response to cytokine
GO:0035855 megakaryocyte development
GO:0035912 dorsal aorta morphogenesis
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043149 stress fiber assembly
GO:0043589 skin morphogenesis
GO:0045059 positive thymic T cell selection
GO:0045214 sarcomere organization
GO:0045597 positive regulation of cell differentiation
GO:0045773 positive regulation of axon extension
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045987 positive regulation of smooth muscle contraction
GO:0046016 positive regulation of transcription by glucose
GO:0046716 muscle cell cellular homeostasis
GO:0048538 thymus development
GO:0048589 developmental growth
GO:0048666 neuron development
GO:0048821 erythrocyte development
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051150 regulation of smooth muscle cell differentiation
GO:0051491 positive regulation of filopodium assembly
GO:0055003 cardiac myofibril assembly
GO:0060055 angiogenesis involved in wound healing
GO:0060218 hematopoietic stem cell differentiation
GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
GO:0060292 long-term synaptic depression
GO:0060324 face development
GO:0060347 heart trabecula formation
GO:0060425 lung morphogenesis
GO:0060532 bronchus cartilage development
GO:0060534 trachea cartilage development
GO:0060947 cardiac vascular smooth muscle cell differentiation
GO:0061029 eyelid development in camera-type eye
GO:0061145 lung smooth muscle development
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
GO:0070830 bicellular tight junction assembly
GO:0070878 primary miRNA binding
GO:0071333 cellular response to glucose stimulus
GO:0090009 primitive streak formation
GO:0090136 epithelial cell-cell adhesion
GO:0090398 cellular senescence
GO:1900222 negative regulation of amyloid-beta clearance
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR002100 Transcription factor, MADS-boxDomainDomain
IPR033897 MADS SRF-likeDomainDomain
IPR036879 Transcription factor, MADS-box superfamilyFamilyHomologous superfamily

Diseases

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Interactions

77 interactions

InteractorPartnerSourcesPublicationsLink
SRF_HUMANMYOD1_HUMANHPRD, MINT8617811 details
SRF_HUMANMYOG_HUMANBioGRID, HPRD, MINT10082523 8617811 details
SRF_HUMANMRTFA_HUMANBioGRID, HPRD, IntAct12397177 14565952 15610731 17599918 21965288 details
SRF_HUMANMYCD_HUMANBioGRID, HPRD, IntAct11439182 12397177 15014501 17360478 19342595 details
SRF_HUMANAL3A1_HUMANBioGRID, IntAct21988832 details
SRF_HUMANCIRBP_HUMANBioGRID, IntAct21988832 details
SRF_HUMANT2FA_HUMANBioGRID, DIP, HPRD7854423 8106390 details
SRF_HUMANELK4_HUMANBioGRID, DIP, HPRD11406578 11846562 17200232 7854423 9271374 details
SRF_HUMANPCNA_HUMANUniProt26030842 details
SRF_HUMANNCOA6_HUMANBioGRID10847592 details
SRF_HUMANPML_HUMANBioGRID, HPRD12622724 details
SRF_HUMANCBP_HUMANBioGRID, HPRD12622724 9388250 details
SRF_HUMANRXRG_HUMANBioGRID, HPRD11641790 details
SRF_HUMANGATA4_HUMANBioGRID, HPRD11003651 11158291 details
SRF_HUMANREL_HUMANBioGRID8670842 details
SRF_HUMANTF65_HUMANBioGRID, HPRD8670842 details
SRF_HUMANNFYA_HUMANBioGRID, HPRD10571058 details
SRF_HUMANFLI1_HUMANBioGRID, HPRD10606656 details
SRF_HUMANELK1_HUMANBioGRID, HPRD10606656 8083237 9010223 details
SRF_HUMANTEAD1_HUMANBioGRID, HPRD11136726 12061776 details
SRF_HUMANSP1_HUMANBioGRID10082523 details
SRF_HUMANNCOR2_HUMANBioGRID, HPRD10777532 details
SRF_HUMANGTF2I_HUMANBioGRID, HPRD12082086 9334314 9584171 details
SRF_HUMANCD63_HUMANBioGRID9271374 details
SRF_HUMANATF6A_HUMANBioGRID, HPRD9271374 details
SRF_HUMANCEBPB_HUMANBioGRID, HPRD10318842 11500490 9032301 details
SRF_HUMANHDAC4_HUMANBioGRID12663674 details
SRF_HUMANKAT5_HUMANBioGRID15591049 details
SRF_HUMANCSK21_HUMANBioGRID, HPRD1740119 2046671 details
SRF_HUMANSRF_HUMANBioGRID, HPRD11406578 2046671 2108863 8083237 details
SRF_HUMANKDM6A_HUMANBioGRID22192413 details
SRF_HUMANTRI63_HUMANBioGRID15802564 details
SRF_HUMANUBC9_HUMANBioGRID12788062 details
SRF_HUMANSHBG_HUMANBioGRID15862967 details
SRF_HUMANPRKDC_HUMANBioGRID, HPRD8407951 details
SRF_HUMANNFKB1_HUMANBioGRID2108863 details
SRF_HUMANSRFB1_HUMANBioGRID, HPRD15492011 8083237 details
SRF_HUMANZIC3_HUMANBioGRID17468179 details
SRF_HUMANFHL1_HUMANBioGRID, HPRD15610731 details
SRF_HUMANFHL2_HUMANBioGRID, HPRD15610731 details
SRF_HUMANTRIP4_HUMANBioGRID12077347 details
SRF_HUMANNCOA1_HUMANBioGRID, HPRD9786846 details
SRF_HUMANRARA_HUMANBioGRID11641790 details
SRF_HUMANRXRA_HUMANBioGRID, HPRD11641790 details
SRF_HUMANFOXK1_HUMANBioGRID17670796 details
SRF_HUMANFOXG1_HUMANBioGRID17670796 details
SRF_HUMANMRTFB_HUMANBioGRID, HPRD, IntAct12397177 14565952 details
SRF_HUMANSSRP1_HUMANBioGRID, HPRD10336466 details
SRF_HUMANNKX31_HUMANBioGRID, HPRD10993896 details
SRF_HUMANSMCA4_HUMANBioGRID17599918 19342595 details
SRF_HUMANHDAC3_HUMANBioGRID17158926 details
SRF_HUMANSMAD7_HUMANBioGRID16690609 details
SRF_HUMANEPC1_HUMANBioGRID19359245 details
SRF_HUMANPELP1_HUMANBioGRID15456770 details
SRF_HUMANPRRX1_HUMANHPRD9334314 details
SRF_HUMANSRC_HUMANHPRD9786846 details
SRF_HUMANOGT1_HUMANHPRD1512232 details
SRF_HUMANNKX25_HUMANHPRD8887666 details
SRF_HUMANCASP3_HUMANHPRD11387340 details
SRF_HUMANHMGA1_HUMANHPRD9545312 details
SRF_HUMANETV4_HUMANHPRD7796532 details
SRF_HUMANCRIP2_HUMANHPRD12530967 details
SRF_HUMANKS6A1_HUMANHPRD10318869 10753652 8413226 details
SRF_HUMANCASP7_HUMANHPRD11387340 details
SRF_HUMANNKX23_HUMANHPRD11457859 details
SRF_HUMANASC_HUMANHPRD10847592 details
SRF_HUMANHOP_HUMANHPRD12297045 details
SRF_HUMANMAPK2_HUMANHPRD10318869 10753652 12171911 8413226 details
SRF_HUMANBARX2_HUMANHPRD11278942 details
SRF_HUMANFHL3_HUMANHPRD15610731 details
SRF_HUMANFHL5_HUMANHPRD15610731 details
SRF_HUMANCREB1_HUMANHPRD7551568 9388250 details
SRF_HUMANCASP6_HUMANHPRD11387340 details
SRF_HUMANCASP8_HUMANHPRD11387340 details
SRF_HUMANCASP9_HUMANHPRD11387340 details
SRF_HUMANMINP1_HUMANHPRD18497331 details
SRF_HUMANTFE2_HUMANHPRD8617811 details