Entity Details

Primary name HCLS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14317
EntryNameHCLS1_HUMAN
FullNameHematopoietic lineage cell-specific protein
TaxID9606
Evidenceevidence at protein level
Length486
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesHCLS1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006355 regulation of transcription, DNA-templated
GO:0008284 positive regulation of cell population proliferation
GO:0009725 response to hormone
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0030041 actin filament polymerization
GO:0030218 erythrocyte differentiation
GO:0030427 site of polarized growth
GO:0030833 regulation of actin filament polymerization
GO:0030854 positive regulation of granulocyte differentiation
GO:0030864 cortical actin cytoskeleton
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035556 intracellular signal transduction
GO:0042307 positive regulation of protein import into nucleus
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0045651 positive regulation of macrophage differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051015 actin filament binding
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0071345 cellular response to cytokine stimulus
GO:2000107 negative regulation of leukocyte apoptotic process
GO:2000251 positive regulation of actin cytoskeleton reorganization

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Mitochondrion

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR003134 Hs1/CortactinRepeatRepeat
IPR028534 Hematopoietic lineage cell-specific proteinFamilyFamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
HCLS1_HUMANSH24A_HUMANBioGRID, HPRD, IntAct16189514 25416956 31515488 32296183 details
HCLS1_HUMANQKI_HUMANBioGRID, HPRD, IntAct16713569 details
HCLS1_HUMANWIPF1_HUMANmbinfo21398607 details
HCLS1_HUMANCASP3_HUMANBioGRID, HPRD, IntAct11689006 11988074 25241761 details
HCLS1_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
HCLS1_HUMAN3BP2_HUMANBioGRID, IntAct32296183 details
HCLS1_HUMANADA10_HUMANUniProt25036101 details
HCLS1_HUMANSSBP3_HUMANBioGRID, IntAct20211142 details
HCLS1_HUMANTRI29_HUMANBioGRID, IntAct20211142 details
HCLS1_HUMANZBT25_HUMANBioGRID, IntAct20211142 details
HCLS1_HUMANLZTR1_HUMANBioGRID, IntAct20211142 details
HCLS1_HUMANGO45_HUMANBioGRID, IntAct20211142 details
HCLS1_HUMANNEMO_HUMANBioGRID, IntAct20211142 details
HCLS1_HUMANCSK21_HUMANBioGRID, HPRD10806407 11988074 details
HCLS1_HUMANARP3_HUMANBioGRID12534372 details
HCLS1_HUMANFGR_HUMANBioGRID, HPRD10066823 details
HCLS1_HUMANGRB2_HUMANBioGRID9670936 details
HCLS1_HUMANHAX1_HUMANHPRD9058808 details
HCLS1_HUMANLYN_HUMANBioGRID, HPRD, MINT10066823 15795233 7682714 9104825 details
HCLS1_HUMANWASP_HUMANHPRD, mbinfo15166239 21398607 details
HCLS1_HUMANKSYK_HUMANBioGRID, HPRD, IntAct25241761 9104825 details
HCLS1_HUMANM4K1_HUMANBioGRID, HPRD10233887 details
HCLS1_HUMANCD79A_HUMANBioGRID, HPRD7927516 details
HCLS1_HUMANKCNA3_HUMANBioGRID25739456 details
HCLS1_HUMANU2AF2_HUMANBioGRID26641092 details
HCLS1_HUMANH1BP3_HUMANHPRD10590261 details
HCLS1_HUMANARP2_HUMANHPRD12534372 details
HCLS1_HUMANACTS_HUMANHPRD12534372 details