Entity Details

Primary name DRD2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14416
EntryNameDRD2_HUMAN
FullNameD(2) dopamine receptor
TaxID9606
Evidenceevidence at protein level
Length443
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesDRD2

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0001659 temperature homeostasis
GO:0001666 response to hypoxia
GO:0001669 acrosomal vesicle
GO:0001933 negative regulation of protein phosphorylation
GO:0001975 response to amphetamine
GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure
GO:0002027 regulation of heart rate
GO:0002028 regulation of sodium ion transport
GO:0002031 G protein-coupled receptor internalization
GO:0002052 positive regulation of neuroblast proliferation
GO:0002092 positive regulation of receptor internalization
GO:0004930 G protein-coupled receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005929 cilium
GO:0006874 cellular calcium ion homeostasis
GO:0006914 autophagy
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007270 neuron-neuron synaptic transmission
GO:0007409 axonogenesis
GO:0007416 synapse assembly
GO:0007608 sensory perception of smell
GO:0007616 long-term memory
GO:0007625 grooming behavior
GO:0007626 locomotory behavior
GO:0007628 adult walking behavior
GO:0008104 protein localization
GO:0008285 negative regulation of cell population proliferation
GO:0008306 associative learning
GO:0008542 visual learning
GO:0009416 response to light stimulus
GO:0009636 response to toxic substance
GO:0010039 response to iron ion
GO:0014059 regulation of dopamine secretion
GO:0014069 postsynaptic density
GO:0014854 response to inactivity
GO:0015459 potassium channel regulator activity
GO:0016055 Wnt signaling pathway
GO:0016328 lateral plasma membrane
GO:0021756 striatum development
GO:0021769 orbitofrontal cortex development
GO:0021853 cerebral cortex GABAergic interneuron migration
GO:0021984 adenohypophysis development
GO:0030139 endocytic vesicle
GO:0030336 negative regulation of cell migration
GO:0030424 axon
GO:0030425 dendrite
GO:0030432 peristalsis
GO:0030672 synaptic vesicle membrane
GO:0031223 auditory behavior
GO:0032147 activation of protein kinase activity
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0032467 positive regulation of cytokinesis
GO:0032922 circadian regulation of gene expression
GO:0033602 negative regulation of dopamine secretion
GO:0034776 response to histamine
GO:0035094 response to nicotine
GO:0035240 dopamine binding
GO:0035255 ionotropic glutamate receptor binding
GO:0035556 intracellular signal transduction
GO:0035810 positive regulation of urine volume
GO:0035815 positive regulation of renal sodium excretion
GO:0036126 sperm flagellum
GO:0040018 positive regulation of multicellular organism growth
GO:0042220 response to cocaine
GO:0042321 negative regulation of circadian sleep/wake cycle, sleep
GO:0042417 dopamine metabolic process
GO:0042493 response to drug
GO:0042756 drinking behavior
GO:0042802 identical protein binding
GO:0043197 dendritic spine
GO:0043204 perikaryon
GO:0043266 regulation of potassium ion transport
GO:0043278 response to morphine
GO:0043473 pigmentation
GO:0043666 regulation of phosphoprotein phosphatase activity
GO:0043679 axon terminus
GO:0044877 protein-containing complex binding
GO:0045202 synapse
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
GO:0045776 negative regulation of blood pressure
GO:0045824 negative regulation of innate immune response
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046676 negative regulation of insulin secretion
GO:0046717 acid secretion
GO:0048148 behavioral response to cocaine
GO:0048149 behavioral response to ethanol
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048678 response to axon injury
GO:0048755 branching morphogenesis of a nerve
GO:0050482 arachidonic acid secretion
GO:0050709 negative regulation of protein secretion
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
GO:0051584 regulation of dopamine uptake involved in synaptic transmission
GO:0051586 positive regulation of dopamine uptake involved in synaptic transmission
GO:0051823 regulation of synapse structural plasticity
GO:0051898 negative regulation of protein kinase B signaling
GO:0051967 negative regulation of synaptic transmission, glutamatergic
GO:0060079 excitatory postsynaptic potential
GO:0060124 positive regulation of growth hormone secretion
GO:0060134 prepulse inhibition
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
GO:0060160 negative regulation of dopamine receptor signaling pathway
GO:0060170 ciliary membrane
GO:0060548 negative regulation of cell death
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0090325 regulation of locomotion involved in locomotory behavior
GO:0097730 non-motile cilium
GO:0098691 dopaminergic synapse
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:0099055 integral component of postsynaptic membrane
GO:0099056 integral component of presynaptic membrane
GO:0099170 postsynaptic modulation of chemical synaptic transmission
GO:1900168 positive regulation of glial cell-derived neurotrophic factor production
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1901386 negative regulation of voltage-gated calcium channel activity
GO:1990384 hyaloid vascular plexus regression
GO:2000300 regulation of synaptic vesicle exocytosis

Subcellular Location

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Subcellular Location
Cell membrane
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000929 Dopamine receptor familyFamilyFamily
IPR001922 Dopamine D2 receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00182 AmphetamineDrugbanksmall molecule
DB00246 ZiprasidoneDrugbanksmall molecule
DB00248 CabergolineDrugbanksmall molecule
DB00268 RopiniroleDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00372 ThiethylperazineDrugbanksmall molecule
DB00391 SulpirideDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00409 RemoxiprideDrugbanksmall molecule
DB00413 PramipexoleDrugbanksmall molecule
DB00420 PromazineDrugbanksmall molecule
DB00433 ProchlorperazineDrugbanksmall molecule
DB00450 DroperidolDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00490 BuspironeDrugbanksmall molecule
DB00502 HaloperidolDrugbanksmall molecule
DB00508 TriflupromazineDrugbanksmall molecule
DB00540 NortriptylineDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00555 LamotrigineDrugbanksmall molecule
DB00568 CinnarizineDrugbanksmall molecule
DB00589 LisurideDrugbanksmall molecule
DB00623 FluphenazineDrugbanksmall molecule
DB00679 ThioridazineDrugbanksmall molecule
DB00696 ErgotamineDrugbanksmall molecule
DB00714 ApomorphineDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00734 RisperidoneDrugbanksmall molecule
DB00777 PropiomazineDrugbanksmall molecule
DB00805 MinaprineDrugbanksmall molecule
DB00831 TrifluoperazineDrugbanksmall molecule
DB00850 PerphenazineDrugbanksmall molecule
DB00875 FlupentixolDrugbanksmall molecule
DB00915 AmantadineDrugbanksmall molecule
DB00933 MesoridazineDrugbanksmall molecule
DB00934 MaprotilineDrugbanksmall molecule
DB00988 DopamineDrugbanksmall molecule
DB01038 CarphenazineDrugbanksmall molecule
DB01043 MemantineDrugbanksmall molecule
DB01049 Ergoloid mesylateDrugbanksmall molecule
DB01063 AcetophenazineDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01100 PimozideDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01175 EscitalopramDrugbanksmall molecule
DB01184 DomperidoneDrugbanksmall molecule
DB01186 PergolideDrugbanksmall molecule
DB01200 BromocriptineDrugbanksmall molecule
DB01221 KetamineDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01233 MetoclopramideDrugbanksmall molecule
DB01235 LevodopaDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01239 ChlorprothixeneDrugbanksmall molecule
DB01267 PaliperidoneDrugbanksmall molecule
DB01392 YohimbineDrugbanksmall molecule
DB01403 MethotrimeprazineDrugbanksmall molecule
DB01425 AlizaprideDrugbanksmall molecule
DB01549 RolicyclidineDrugbanksmall molecule
DB01614 AcepromazineDrugbanksmall molecule
DB01618 MolindoneDrugbanksmall molecule
DB01621 PipotiazineDrugbanksmall molecule
DB01622 ThioproperazineDrugbanksmall molecule
DB01623 ThiothixeneDrugbanksmall molecule
DB01624 ZuclopenthixolDrugbanksmall molecule
DB04599 AniracetamDrugbanksmall molecule
DB04842 FluspirileneDrugbanksmall molecule
DB04844 TetrabenazineDrugbanksmall molecule
DB04857 BrasofensineDrugbanksmall molecule
DB04888 BifeprunoxDrugbanksmall molecule
DB04889 BicifadineDrugbanksmall molecule
DB04924 ItoprideDrugbanksmall molecule
DB04946 IloperidoneDrugbanksmall molecule
DB05271 RotigotineDrugbanksmall molecule
DB05316 PimavanserinDrugbanksmall molecule
DB05687 BL-1020Drugbanksmall molecule
DB05766 ACP-104Drugbanksmall molecule
DB05964 AmitifadineDrugbanksmall molecule
DB06016 CariprazineDrugbanksmall molecule
DB06077 LumateperoneDrugbanksmall molecule
DB06109 YKP-1358Drugbanksmall molecule
DB06144 SertindoleDrugbanksmall molecule
DB06148 MianserinDrugbanksmall molecule
DB06216 AsenapineDrugbanksmall molecule
DB06229 OcaperidoneDrugbanksmall molecule
DB06288 AmisulprideDrugbanksmall molecule
DB06454 SarizotanDrugbanksmall molecule
DB06477 SumaniroleDrugbanksmall molecule
DB08815 LurasidoneDrugbanksmall molecule
DB08922 PerospironeDrugbanksmall molecule
DB09018 BromoprideDrugbanksmall molecule
DB09097 QuinagolideDrugbanksmall molecule
DB09128 BrexpiprazoleDrugbanksmall molecule
DB09194 EtoperidoneDrugbanksmall molecule
DB09207 AS-8112Drugbanksmall molecule
DB09223 BlonanserinDrugbanksmall molecule
DB09224 MelperoneDrugbanksmall molecule
DB09225 ZotepineDrugbanksmall molecule
DB09286 PipamperoneDrugbanksmall molecule
DB11274 Dihydro-alpha-ergocryptineDrugbanksmall molecule
DB11275 EpicriptineDrugbanksmall molecule
DB12061 PardoprunoxDrugbanksmall molecule
DB12093 TetrahydropalmatineDrugbanksmall molecule
DB12478 PiribedilDrugbanksmall molecule
DB12518 RacloprideDrugbanksmall molecule
DB12579 JNJ-37822681Drugbanksmall molecule
DB13025 TiaprideDrugbanksmall molecule
DB13345 DihydroergocristineDrugbanksmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule

Interactions

105 interactions

InteractorPartnerSourcesPublicationsLink
DRD2_HUMANSC6A3_HUMANHPRD, MINT17380124 details
DRD2_HUMANNEB2_HUMANBioGRID, HPRD, MINT10391935 17464283 details
DRD2_HUMANDRD2_HUMANBioGRID, IntAct, MINT17706924 18668123 21184734 23624386 23637801 28734930 details
DRD2_HUMANCALM2_HUMANBioGRID, I2D16051151 19632986 28298427 details
DRD2_HUMANAA2AR_HUMANBioGRID, HPRD, I2D, IntAct12804599 19632986 23296780 29568380 details
DRD2_HUMANDRD4_HUMANIntAct21184734 details
DRD2_HUMANARRB2_HUMANBioGRID, IntAct21256133 25162404 32450252 details
DRD2_HUMANAPH1A_HUMANBioGRID, MINT28298427 details
DRD2_HUMANGHITM_HUMANBioGRID, MINT28298427 details
DRD2_HUMANRTN3_HUMANBioGRID, MINT28298427 details
DRD2_HUMANLPAR1_HUMANBioGRID, MINT28298427 details
DRD2_HUMANBAP29_HUMANBioGRID, MINT28298427 details
DRD2_HUMANSNG2_HUMANBioGRID, MINT28298427 details
DRD2_HUMANTRAM1_HUMANBioGRID, MINT28298427 details
DRD2_HUMANYIPF3_HUMANBioGRID, MINT28298427 details
DRD2_HUMANCERS1_HUMANBioGRID, MINT28298427 details
DRD2_HUMANS35B1_HUMANBioGRID, MINT28298427 details
DRD2_HUMANZDHC4_HUMANBioGRID, MINT28298427 details
DRD2_HUMANGASR_HUMANBioGRID, MINT28298427 details
DRD2_HUMANAR6P6_HUMANBioGRID, MINT28298427 details
DRD2_HUMANCLDN1_HUMANBioGRID, MINT28298427 details
DRD2_HUMANABCA2_HUMANBioGRID, MINT28298427 details
DRD2_HUMANS22AH_HUMANBioGRID, MINT28298427 details
DRD2_HUMANTTYH1_HUMANBioGRID, MINT28298427 details
DRD2_HUMANWLS_HUMANBioGRID, MINT28298427 details
DRD2_HUMANGABR1_HUMANBioGRID, MINT28298427 details
DRD2_HUMANB3A3_HUMANBioGRID, MINT28298427 details
DRD2_HUMANLFG1_HUMANBioGRID, MINT28298427 details
DRD2_HUMANVPP2_HUMANBioGRID, MINT28298427 details
DRD2_HUMANARL1_HUMANBioGRID, MINT28298427 details
DRD2_HUMANVATL_HUMANBioGRID, MINT28298427 details
DRD2_HUMANBAP31_HUMANBioGRID, MINT28298427 details
DRD2_HUMANAGRB1_HUMANBioGRID, MINT28298427 details
DRD2_HUMANCHPT1_HUMANBioGRID, MINT28298427 details
DRD2_HUMANGPR37_HUMANBioGRID, MINT28298427 details
DRD2_HUMANCREL1_HUMANBioGRID, MINT28298427 details
DRD2_HUMANSMIM7_HUMANBioGRID, MINT28298427 details
DRD2_HUMANAGRG1_HUMANBioGRID, MINT28298427 details
DRD2_HUMANGABR2_HUMANBioGRID, MINT28298427 details
DRD2_HUMANGDPD2_HUMANBioGRID, MINT28298427 details
DRD2_HUMANCERS2_HUMANBioGRID, MINT28298427 details
DRD2_HUMANNDUV1_HUMANBioGRID, MINT28298427 details
DRD2_HUMANPIGG_HUMANBioGRID, MINT28298427 details
DRD2_HUMANPLLP_HUMANBioGRID, MINT28298427 details
DRD2_HUMANPLPR3_HUMANBioGRID, MINT28298427 details
DRD2_HUMANPAQR6_HUMANBioGRID, MINT28298427 details
DRD2_HUMANRTN1_HUMANBioGRID, MINT28298427 details
DRD2_HUMANRTN4_HUMANBioGRID, MINT28298427 details
DRD2_HUMANRHBD2_HUMANBioGRID, MINT28298427 details
DRD2_HUMANOSTP_HUMANBioGRID, MINT28298427 details
DRD2_HUMANSERC3_HUMANBioGRID, MINT28298427 details
DRD2_HUMANS15A4_HUMANBioGRID, MINT28298427 details
DRD2_HUMANSC6A1_HUMANBioGRID, MINT28298427 details
DRD2_HUMANTSN3_HUMANBioGRID, MINT28298427 details
DRD2_HUMANTSN7_HUMANBioGRID, MINT28298427 details
DRD2_HUMANG137A_HUMANBioGRID, MINT28298427 details
DRD2_HUMANTM101_HUMANBioGRID, MINT28298427 details
DRD2_HUMANCSCL1_HUMANBioGRID, MINT28298427 details
DRD2_HUMANTRFE_HUMANBioGRID, MINT28298427 details
DRD2_HUMANTMM11_HUMANBioGRID, MINT28298427 details
DRD2_HUMANTEFF2_HUMANBioGRID, MINT28298427 details
DRD2_HUMANWFS1_HUMANBioGRID, MINT28298427 details
DRD2_HUMANGNAI1_HUMANIntAct28734930 details
DRD2_HUMANGNAS3_HUMANIntAct28734930 details
DRD2_HUMANGNAS2_HUMANIntAct28734930 details
DRD2_HUMANGNAS1_HUMANIntAct28734930 details
DRD2_HUMANNTR1_HUMANIntAct23624386 details
DRD2_HUMAN5HT2A_HUMANIntAct20888323 details
DRD2_HUMANSGMR1_HUMANIntAct23637801 details
DRD2_HUMANCLIC6_HUMANBioGRID, HPRD14499480 details
DRD2_HUMANNCS1_HUMANBioGRID, HPRD12351722 14709338 21875085 details
DRD2_HUMANE41L1_HUMANBioGRID, HPRD12181426 details
DRD2_HUMANFLNA_HUMANBioGRID, HPRD11911837 12181426 details
DRD2_HUMANPAWR_HUMANBioGRID16051151 details
DRD2_HUMANCALM1_HUMANBioGRID16051151 28298427 details
DRD2_HUMANCALM3_HUMANBioGRID16051151 28298427 details
DRD2_HUMANGNB5_HUMANBioGRID25162404 details
DRD2_HUMANNFM_HUMANBioGRID12122054 details
DRD2_HUMANSSR2_HUMANBioGRID17706924 details
DRD2_HUMANTRPC1_HUMANBioGRID18261457 details
DRD2_HUMANTRPC4_HUMANBioGRID18261457 details
DRD2_HUMANTRPC5_HUMANBioGRID18261457 details
DRD2_HUMANOPRM_HUMANBioGRID31416253 details
DRD2_HUMANHRH3_HUMANBioGRID18547596 details
DRD2_HUMANKBTB7_HUMANBioGRID32572597 details
DRD2_HUMANKBTB6_HUMANBioGRID32572597 details
DRD2_HUMANGIPC1_HUMANHPRD14617818 details
DRD2_HUMANCAPS2_HUMANHPRD15857609 details
DRD2_HUMANOXYR_HUMANIntAct22824810 details
DRD2_HUMANKCNJ3_HUMANBioGRID12297500 details
DRD2_HUMANKCNJ6_HUMANBioGRID, HPRD12297500 details
DRD2_HUMANKCNJ5_HUMANBioGRID12297500 details
DRD2_HUMANKPCB_HUMANBioGRID29054428 details
DRD2_HUMANDYN1_HUMANBioGRID14709338 details
DRD2_HUMANDYN2_HUMANBioGRID14709338 details
DRD2_HUMANMDM2_HUMANBioGRID32828283 details
DRD2_HUMANCAPS1_HUMANHPRD15857609 details
DRD2_HUMANGRIA2_HUMANHPRD15858065 details
DRD2_HUMANNSF_HUMANHPRD15858065 details
DRD2_HUMANEPB41_HUMANHPRD12181426 details
DRD2_HUMANGNAZ_HUMANHPRD9166747 details
DRD2_HUMANGNAI2_HUMANHPRD10978845 details
DRD2_HUMANGNAI3_HUMANHPRD10978845 details
DRD2_HUMANSSR5_HUMANHPRD10753124 details
DRD2_HUMANKCNJ9_HUMANHPRD12297500 details