Entity Details

Primary name LYAM2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16581
EntryNameLYAM2_HUMAN
FullNameE-selectin
TaxID9606
Evidenceevidence at protein level
Length610
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesSELE

GO terms

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GOName
GO:0002092 positive regulation of receptor internalization
GO:0002523 leukocyte migration involved in inflammatory response
GO:0004888 transmembrane signaling receptor activity
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0005905 clathrin-coated pit
GO:0006954 inflammatory response
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 leukocyte cell-cell adhesion
GO:0007202 activation of phospholipase C activity
GO:0019722 calcium-mediated signaling
GO:0030029 actin filament-based process
GO:0030863 cortical cytoskeleton
GO:0032496 response to lipopolysaccharide
GO:0033691 sialic acid binding
GO:0034612 response to tumor necrosis factor
GO:0043274 phospholipase binding
GO:0045121 membrane raft
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0050727 regulation of inflammatory response
GO:0050900 leukocyte migration
GO:0050901 leukocyte tethering or rolling
GO:0070492 oligosaccharide binding
GO:0070555 response to interleukin-1
GO:1903238 positive regulation of leukocyte tethering or rolling

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000436 Sushi/SCR/CCP domainDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001304 C-type lectin-likeDomainDomain
IPR002396 Selectin superfamilyFamilyFamily
IPR016186 C-type lectin-like/link domain superfamilyFamilyHomologous superfamily
IPR016187 C-type lectin foldFamilyHomologous superfamily
IPR018378 C-type lectin, conserved siteSiteConserved site
IPR033991 Selectin, C-type lectin-like domainDomainDomain
IPR035976 Sushi/SCR/CCP superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01136 CarvedilolDrugbanksmall molecule
DB03721 N-acetyl-alpha-neuraminic acidDrugbanksmall molecule
DB06423 EndostatinDrugbankbiotech