Entity Details

Primary name ASM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17405
EntryNameASM_HUMAN
FullNameSphingomyelin phosphodiesterase
TaxID9606
Evidenceevidence at protein level
Length631
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesSMPD1

GO terms

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GOName
GO:0001778 plasma membrane repair
GO:0004767 sphingomyelin phosphodiesterase activity
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005768 endosome
GO:0005811 lipid droplet
GO:0005886 plasma membrane
GO:0006684 sphingomyelin metabolic process
GO:0006685 sphingomyelin catabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0007165 signal transduction
GO:0007399 nervous system development
GO:0008081 phosphoric diester hydrolase activity
GO:0008203 cholesterol metabolic process
GO:0008270 zinc ion binding
GO:0009615 response to virus
GO:0010212 response to ionizing radiation
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0023021 termination of signal transduction
GO:0034340 response to type I interferon
GO:0034612 response to tumor necrosis factor
GO:0034644 cellular response to UV
GO:0035307 positive regulation of protein dephosphorylation
GO:0036019 endolysosome
GO:0042060 wound healing
GO:0042220 response to cocaine
GO:0042493 response to drug
GO:0042599 lamellar body
GO:0043065 positive regulation of apoptotic process
GO:0043202 lysosomal lumen
GO:0043407 negative regulation of MAP kinase activity
GO:0045807 positive regulation of endocytosis
GO:0046513 ceramide biosynthetic process
GO:0046718 viral entry into host cell
GO:0061750 acid sphingomyelin phosphodiesterase activity
GO:0070062 extracellular exosome
GO:0070555 response to interleukin-1
GO:0071277 cellular response to calcium ion

Subcellular Location

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Subcellular Location
Lipid droplet
Lysosome
Secreted

Domains

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DomainNameCategoryType
IPR004843 Calcineurin-like phosphoesterase domain, ApaH typeDomainDomain
IPR008139 Saposin B type domainDomainDomain
IPR011001 Saposin-likeFamilyHomologous superfamily
IPR011160 Sphingomyelin phosphodiesteraseFamilyFamily
IPR029052 Metallo-dependent phosphatase-likeFamilyHomologous superfamily
IPR041805 Acid sphingomyelinase/endopolyphosphatase, metallophosphatase domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00381 AmlodipineDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech