Entity Details

Primary name HLAG_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17693
EntryNameHLAG_HUMAN
FullNameHLA class I histocompatibility antigen, alpha chain G
TaxID9606
Evidenceevidence at protein level
Length338
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesHLA-G

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001915 negative regulation of T cell mediated cytotoxicity
GO:0002451 peripheral B cell tolerance induction
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0002645 positive regulation of tolerance induction
GO:0002666 positive regulation of T cell tolerance induction
GO:0002729 positive regulation of natural killer cell cytokine production
GO:0002767 immune response-inhibiting cell surface receptor signaling pathway
GO:0005102 signaling receptor binding
GO:0005615 extracellular space
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0006968 cellular defense response
GO:0009897 external side of plasma membrane
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0016525 negative regulation of angiogenesis
GO:0030670 phagocytic vesicle membrane
GO:0031527 filopodium membrane
GO:0031901 early endosome membrane
GO:0032735 positive regulation of interleukin-12 production
GO:0033106 cis-Golgi network membrane
GO:0042130 negative regulation of T cell proliferation
GO:0042270 protection from natural killer cell mediated cytotoxicity
GO:0042605 peptide antigen binding
GO:0042610 CD8 receptor binding
GO:0042612 MHC class I protein complex
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0045591 positive regulation of regulatory T cell differentiation
GO:0045953 negative regulation of natural killer cell mediated cytotoxicity
GO:0050776 regulation of immune response
GO:0050777 negative regulation of immune response
GO:0051898 negative regulation of protein kinase B signaling
GO:0055038 recycling endosome membrane
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0060907 positive regulation of macrophage cytokine production
GO:0070207 protein homotrimerization
GO:0070317 negative regulation of G0 to G1 transition
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
GO:2000353 positive regulation of endothelial cell apoptotic process
GO:2000774 positive regulation of cellular senescence
GO:2001199 negative regulation of dendritic cell differentiation

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Early endosome
Early endosome membrane
Endoplasmic reticulum membrane
Secreted

Domains

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DomainNameCategoryType
IPR001039 MHC class I alpha chain, alpha1 alpha2 domainsDomainDomain
IPR003006 Immunoglobulin/major histocompatibility complex, conserved siteSiteConserved site
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR011161 MHC class I-like antigen recognition-likeDomainDomain
IPR011162 MHC classes I/II-like antigen recognition proteinFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR037055 MHC class I-like antigen recognition-like superfamilyFamilyHomologous superfamily

Diseases

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