Entity Details

Primary name TNR1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19438
EntryNameTNR1A_HUMAN
FullNameTumor necrosis factor receptor superfamily member 1A
TaxID9606
Evidenceevidence at protein level
Length455
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesTNFRSF1A

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0002947 tumor necrosis factor receptor superfamily complex
GO:0003176 aortic valve development
GO:0003177 pulmonary valve development
GO:0003332 negative regulation of extracellular matrix constituent secretion
GO:0005031 tumor necrosis factor-activated receptor activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006693 prostaglandin metabolic process
GO:0006954 inflammatory response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009986 cell surface
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016020 membrane
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042742 defense response to bacterium
GO:0042802 identical protein binding
GO:0043120 tumor necrosis factor binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043235 receptor complex
GO:0045121 membrane raft
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050728 negative regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0071260 cellular response to mechanical stimulus
GO:0071550 death-inducing signaling complex assembly
GO:0072659 protein localization to plasma membrane
GO:1902339 positive regulation of apoptotic process involved in morphogenesis
GO:1903140 regulation of establishment of endothelial barrier
GO:2000304 positive regulation of ceramide biosynthetic process

Subcellular Location

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Subcellular Location
Cell membrane
Golgi apparatus membrane
Secreted

Domains

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DomainNameCategoryType
IPR000488 Death domainDomainDomain
IPR001368 TNFR/NGFR cysteine-rich regionDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR020419 Tumour necrosis factor receptor 1AFamilyFamily
IPR033993 Tumor necrosis factor receptor 1A, N-terminalDomainDomain
IPR033994 Tumor necrosis factor receptor 1A, death domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB03507 6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-OneDrugbanksmall molecule
DB11626 TasonerminDrugbankbiotech

Interactions

198 interactions

InteractorPartnerSourcesPublicationsLink
TNR1A_HUMANTRADD_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt10187805 11035039 11684708 11821416 11934887 15310755 16611992 16919273 18776134 18939944 19524513 19641494 19781631 21724995 22297296 23429285 23955153 24130170 24758719 27552911 28514442 29108854 30420664 7758105 8565075 8612133 8621670 8943045 9082980 9915703 details
TNR1A_HUMANTNR1A_HUMANBioGRID, DIP, HPRD, IntAct10875917 14743216 21988832 22801493 28205554 7758105 8077196 9126987 details
TNR1A_HUMANFAN_HUMANBioGRID, HPRD, MINT10187805 17599063 8808629 details
TNR1A_HUMANRIPK1_HUMANBioGRID, HPRD, IntAct, UniProt11002422 15258597 16115877 16611992 16968706 18022363 18450452 18621737 18724939 18939944 18949366 19524513 19773432 19781631 19815541 20448643 20825417 21113135 21331078 21737329 22179575 22733818 22817896 22848449 23429285 24098568 24130170 24758719 25388546 25681446 26802121 27321185 27552911 27591049 28388439 28514442 28817177 29431638 30420664 31406107 8612133 8985253 details
TNR1A_HUMANIKKA_HUMANBioGRID, HPRD10755617 18949366 21724995 30420664 details
TNR1A_HUMANTNFA_HUMANBioGRID, DIP, HPRD, IntAct, MINT10634209 11448951 12753742 12887920 1310388 14743216 15173183 15485837 19084540 20080539 20103630 2170559 22028622 22099304 22675546 22801493 23032187 23746843 23955153 24070898 24726327 24980434 25241761 25911380 26186194 26670046 27307491 27545878 27560715 2848815 28514442 30420664 31898971 8182064 8288897 8805640 9568681 details
TNR1A_HUMANUBQL1_HUMANBioGRID, IntAct21988832 details
TNR1A_HUMANIKKB_HUMANBioGRID, HPRD, IntAct10755617 11002417 11821416 18949366 21331078 21724995 25241761 30420664 31406107 details
TNR1A_HUMANTRAP1_HUMANBioGRID, HPRD7876093 details
TNR1A_HUMANJAK2_HUMANBioGRID, HPRD18606683 9510175 details
TNR1A_HUMANKPCD_HUMANBioGRID11078718 details
TNR1A_HUMANERAP1_HUMANHPRD, IntAct12189246 details
TNR1A_HUMANATF6A_HUMANBioGRID, IntAct21988832 details
TNR1A_HUMANBAG4_HUMANBioGRID, HPRD11909948 9915703 details
TNR1A_HUMANMADD_HUMANBioGRID, HPRD9115275 details
TNR1A_HUMANMK01_HUMANBioGRID, HPRD11606045 19850087 details
TNR1A_HUMANSGTA_HUMANBioGRID, IntAct21988832 details
TNR1A_HUMANTNFB_HUMANBioGRID, HPRD1310388 8182064 8288897 8387891 details
TNR1A_HUMANTRAF1_HUMANBioGRID, HPRD19287455 7859281 8565075 details
TNR1A_HUMANPI42B_HUMANBioGRID, HPRD9038203 9753329 details
TNR1A_HUMANTP4AP_HUMANBioGRID, HPRD14585990 20458742 details
TNR1A_HUMANSRC_HUMANBioGRID15707590 18606683 9237663 details
TNR1A_HUMANMAGH1_HUMANBioGRID21418516 details
TNR1A_HUMANCASP7_HUMANBioGRID, HPRD, MINT11755217 21157428 details
TNR1A_HUMANBCL10_HUMANBioGRID10400625 details
TNR1A_HUMANUBC9_HUMANBioGRID, HPRD9563508 details
TNR1A_HUMANJAK1_HUMANBioGRID, HPRD11801527 9510175 details
TNR1A_HUMANEGFR_HUMANBioGRID, IntAct24658140 25402006 31980649 details
TNR1A_HUMANUCHL1_HUMANBioGRID24980434 details
TNR1A_HUMANGYS2_HUMANBioGRID, IntAct21988832 details
TNR1A_HUMANHRG_HUMANBioGRID, IntAct21988832 details
TNR1A_HUMANSUMO1_HUMANBioGRID, HPRD10187798 8906799 details
TNR1A_HUMANTNFC_HUMANBioGRID, HPRD7995952 details
TNR1A_HUMANCDN2B_HUMANBioGRID28205554 details
TNR1A_HUMANRIFK_HUMANBioGRID, DIP19641494 details
TNR1A_HUMANTNF13_HUMANBioGRID, HPRD10706119 details
TNR1A_HUMANSTABP_HUMANBioGRID24980434 details
TNR1A_HUMANSTK11_HUMANBioGRID28205554 details
TNR1A_HUMANCDK6_HUMANBioGRID28205554 details
TNR1A_HUMANMYOC_HUMANBioGRID, HPRD16289162 details
TNR1A_HUMANKC1AL_HUMANBioGRID8051045 details
TNR1A_HUMANPSMD2_HUMANBioGRID, HPRD7601280 9126987 details
TNR1A_HUMANTNR25_HUMANHPRD8934525 details
TNR1A_HUMANGRN_HUMANMINT24070898 details
TNR1A_HUMANCCND2_HUMANBioGRID28205554 details
TNR1A_HUMANHSP7C_HUMANBioGRID, IntAct11909948 14743216 details
TNR1A_HUMANPRDX3_HUMANBioGRID, IntAct21988832 details
TNR1A_HUMANCLIP3_HUMANBioGRID22297296 details
TNR1A_HUMANAKT1_HUMANBioGRID28205554 details
TNR1A_HUMANTRAF3_HUMANBioGRID7859281 details
TNR1A_HUMANADA17_HUMANBioGRID17010968 details
TNR1A_HUMANDAXX_HUMANBioGRID9215629 details
TNR1A_HUMANAFG32_HUMANIntAct14743216 details
TNR1A_HUMANSE1L1_HUMANIntAct14743216 details
TNR1A_HUMANATPA_HUMANIntAct14743216 details
TNR1A_HUMANFADD_HUMANBioGRID, IntAct11035039 15659383 16611992 8565075 details
TNR1A_HUMANMOES_HUMANBioGRID15659383 details
TNR1A_HUMANHOIL1_HUMANBioGRID27552911 30420664 details
TNR1A_HUMANTBK1_HUMANBioGRID30420664 details
TNR1A_HUMANTIM50_HUMANIntAct14743216 details
TNR1A_HUMANTRAF2_HUMANBioGRID, HPRD, IntAct11821416 15743837 16611992 18022363 18776134 19815541 20333651 20448643 22179575 24735611 25241761 26212014 27321185 28388439 29108854 30420664 30561431 31406107 8565075 8612133 8943045 details
TNR1A_HUMANKC1A_HUMANUniProt18067272 details
TNR1A_HUMANTNAP3_HUMANBioGRID, IntAct20448643 24098568 26802121 30420664 30561431 31406107 details
TNR1A_HUMANTNIP2_HUMANBioGRID, IntAct30420664 30561431 details
TNR1A_HUMANGRB2_HUMANBioGRID, HPRD10359574 19289468 details
TNR1A_HUMANDAPK1_HUMANBioGRID, HPRD12911633 details
TNR1A_HUMANRIPK3_HUMANBioGRID, HPRD10339433 details
TNR1A_HUMANBIRC3_HUMANBioGRID18939944 19815541 30420664 details
TNR1A_HUMANTRPC1_HUMANBioGRID20458742 details
TNR1A_HUMANCYLD_HUMANBioGRID24098568 27552911 27591049 30420664 details
TNR1A_HUMANITCH_HUMANBioGRID32690868 details
TNR1A_HUMANRACK1_HUMANHPRD12391233 details
TNR1A_HUMANHSP76_HUMANIntAct14743216 details
TNR1A_HUMANTBA3C_HUMANIntAct14743216 details
TNR1A_HUMANCASP8_HUMANBioGRID, MINT15659383 21157428 details
TNR1A_HUMANFANCI_HUMANIntAct14743216 details
TNR1A_HUMANDNJA3_HUMANIntAct14743216 details
TNR1A_HUMANBIRC2_HUMANBioGRID, IntAct18022363 19815541 25681446 30420664 30561431 8943045 details
TNR1A_HUMANRHOA_HUMANBioGRID15659383 details
TNR1A_HUMANTAB2_HUMANBioGRID30420664 details
TNR1A_HUMANADT2_HUMANIntAct14743216 details
TNR1A_HUMANDNJA1_HUMANIntAct14743216 details
TNR1A_HUMANDJB12_HUMANIntAct14743216 details
TNR1A_HUMANPYR1_HUMANIntAct14743216 details
TNR1A_HUMANCLH2_HUMANIntAct14743216 details
TNR1A_HUMANMYL6_HUMANIntAct14743216 details
TNR1A_HUMANTANK_HUMANBioGRID30420664 details
TNR1A_HUMANIKKE_HUMANBioGRID30420664 details
TNR1A_HUMANTMC8_HUMANBioGRID23429285 details
TNR1A_HUMANMOAP1_HUMANHPRD15949439 details
TNR1A_HUMANAT1A1_HUMANIntAct14743216 details
TNR1A_HUMANAAAT_HUMANIntAct14743216 details
TNR1A_HUMANCLH1_HUMANIntAct14743216 details
TNR1A_HUMANTNFL6_HUMANBioGRID12753742 15659383 details
TNR1A_HUMANTNR1B_HUMANBioGRID19287455 details
TNR1A_HUMANTNIP1_HUMANBioGRID, IntAct30420664 30561431 details
TNR1A_HUMANRIPK2_HUMANBioGRID, HPRD9642260 details
TNR1A_HUMANM3K7_HUMANBioGRID16115877 16260783 18037881 18949366 21331078 30420664 details
TNR1A_HUMANSHRPN_HUMANBioGRID23746843 27552911 30420664 details
TNR1A_HUMANRNF31_HUMANBioGRID26670046 27552911 27591049 30420664 details
TNR1A_HUMANSPAT2_HUMANBioGRID27307491 30420664 details
TNR1A_HUMANCDIPT_HUMANIntAct14743216 details
TNR1A_HUMANTBB2B_HUMANIntAct14743216 details
TNR1A_HUMANNEMO_HUMANBioGRID, HPRD, IntAct10755617 27552911 30420664 30561431 details
TNR1A_HUMANCASPA_HUMANBioGRID, HPRD11098060 15659383 9045686 details
TNR1A_HUMANRASF5_HUMANBioGRID32690868 details
TNR1A_HUMANERN1_HUMANHPRD16680093 details
TNR1A_HUMANRS3_HUMANIntAct14743216 details
TNR1A_HUMANMON2_HUMANIntAct14743216 details
TNR1A_HUMANRS27_HUMANIntAct14743216 details
TNR1A_HUMANADT3_HUMANIntAct14743216 details
TNR1A_HUMANS61A1_HUMANIntAct14743216 details
TNR1A_HUMANTNR6_HUMANBioGRID15659383 details
TNR1A_HUMANUBC_HUMANBioGRID27552911 details
TNR1A_HUMANXPOT_HUMANIntAct14743216 details
TNR1A_HUMANECHA_HUMANIntAct14743216 details
TNR1A_HUMANATD3A_HUMANIntAct14743216 details
TNR1A_HUMANAT2A2_HUMANIntAct14743216 details
TNR1A_HUMANPTN11_HUMANHPRD, MINT11786908 details
TNR1A_HUMANSTAT1_HUMANBioGRID, HPRD10848577 details
TNR1A_HUMANPK3CA_HUMANBioGRID15707590 details
TNR1A_HUMANSH3K1_HUMANBioGRID15707590 details
TNR1A_HUMANKHDR1_HUMANBioGRID18606683 details
TNR1A_HUMANRUVB1_HUMANIntAct14743216 details
TNR1A_HUMANTBB6_HUMANIntAct14743216 details
TNR1A_HUMANRS27A_HUMANIntAct14743216 details
TNR1A_HUMANERLEC_HUMANIntAct14743216 details
TNR1A_HUMANRL40_HUMANIntAct14743216 details
TNR1A_HUMANTBB5_HUMANIntAct14743216 details
TNR1A_HUMANLRC59_HUMANIntAct14743216 details
TNR1A_HUMANTRPC5_HUMANBioGRID20458742 details
TNR1A_HUMANML12A_HUMANIntAct14743216 details
TNR1A_HUMANMK08_HUMANBioGRID15659383 details
TNR1A_HUMANTRAF6_HUMANBioGRID24758719 details
TNR1A_HUMANNP1L1_HUMANIntAct14743216 details
TNR1A_HUMANH4_HUMANIntAct14743216 details
TNR1A_HUMANOPTN_HUMANBioGRID22675546 details
TNR1A_HUMANP85A_HUMANBioGRID18606683 details
TNR1A_HUMANBIP_HUMANIntAct14743216 details
TNR1A_HUMANRCN2_HUMANIntAct14743216 details
TNR1A_HUMANTBA3D_HUMANIntAct14743216 details
TNR1A_HUMANH2A1B_HUMANIntAct14743216 details
TNR1A_HUMANPTN6_HUMANHPRD, MINT11786908 details
TNR1A_HUMANCASP2_HUMANBioGRID8985253 details
TNR1A_HUMANMUC1_HUMANBioGRID18037881 details
TNR1A_HUMANKPCB_HUMANBioGRID11078718 details
TNR1A_HUMANHAX1_HUMANIntAct14743216 details
TNR1A_HUMANPFKAL_HUMANIntAct14743216 details
TNR1A_HUMANUBB_HUMANBioGRID, IntAct14743216 28514442 details
TNR1A_HUMANKAP3_HUMANUniProt18625701 details
TNR1A_HUMANEZRI_HUMANBioGRID15659383 details
TNR1A_HUMANGDIR1_HUMANBioGRID15659383 details
TNR1A_HUMANKSYK_HUMANBioGRID, HPRD16291755 26212014 details
TNR1A_HUMANOTU7B_HUMANBioGRID28817177 details
TNR1A_HUMANHTRA2_HUMANBioGRID30420664 details
TNR1A_HUMANIPO8_HUMANIntAct14743216 details
TNR1A_HUMANRL23_HUMANIntAct14743216 details
TNR1A_HUMANMYO6_HUMANIntAct14743216 details
TNR1A_HUMANASM_HUMANMINT21157428 details
TNR1A_HUMANDAB2P_HUMANBioGRID15310755 details
TNR1A_HUMANMYH10_HUMANIntAct14743216 details
TNR1A_HUMANTBB4A_HUMANIntAct14743216 details
TNR1A_HUMANGCN1_HUMANIntAct14743216 details
TNR1A_HUMANPRKDC_HUMANIntAct14743216 details
TNR1A_HUMANBID_HUMANBioGRID15659383 details
TNR1A_HUMANUBP4_HUMANBioGRID21331078 details
TNR1A_HUMANPP1A_HUMANBioGRID18949366 details
TNR1A_HUMANSYRC_HUMANIntAct14743216 details
TNR1A_HUMANC1QBP_HUMANIntAct14743216 details
TNR1A_HUMANCALX_HUMANIntAct14743216 details
TNR1A_HUMANACTG_HUMANIntAct14743216 details
TNR1A_HUMANMPCP_HUMANIntAct14743216 details
TNR1A_HUMANRNF8_HUMANBioGRID24980434 details
TNR1A_HUMANHS90A_HUMANHPRD7876093 details
TNR1A_HUMANHS71L_HUMANIntAct14743216 details
TNR1A_HUMANMYH9_HUMANIntAct14743216 details
TNR1A_HUMANRS16_HUMANIntAct14743216 details
TNR1A_HUMANTR10B_HUMANBioGRID15659383 details
TNR1A_HUMANOST48_HUMANIntAct14743216 details
TNR1A_HUMANBABA2_HUMANBioGRID15465831 details
TNR1A_HUMANUBP2_HUMANBioGRID22179575 details
TNR1A_HUMANCBL_HUMANBioGRID15707590 details
TNR1A_HUMANSOS1_HUMANBioGRID19289468 details
TNR1A_HUMANARRD3_HUMANBioGRID29416926 details
TNR1A_HUMANBAG2_HUMANIntAct14743216 details
TNR1A_HUMANGRP75_HUMANIntAct14743216 details
TNR1A_HUMANEPIPL_HUMANIntAct14743216 details
TNR1A_HUMANH31T_HUMANIntAct14743216 details
TNR1A_HUMANH2B1B_HUMANIntAct14743216 details
TNR1A_HUMANSHIP1_HUMANMINT11786908 details
TNR1A_HUMANBIG2_HUMANUniProt17276987 details
TNR1A_HUMANCRADD_HUMANBioGRID8985253 details
TNR1A_HUMANTRPC4_HUMANBioGRID20458742 details
TNR1A_HUMANRASF1_HUMANHPRD15949439 details
TNR1A_HUMANSSRD_HUMANIntAct14743216 details
TNR1A_HUMANCALM2_HUMANIntAct14743216 details
TNR1A_HUMANFYN_HUMANBioGRID12753742 details
TNR1A_HUMANCAV1_HUMANBioGRID12753742 details