Entity Details

Primary name VATB2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21281
EntryNameVATB2_HUMAN
FullNameV-type proton ATPase subunit B, brain isoform
TaxID9606
Evidenceevidence at protein level
Length511
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesATP6V1B2

GO terms

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GOName
GO:0001726 ruffle
GO:0005524 ATP binding
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0008286 insulin receptor signaling pathway
GO:0012505 endomembrane system
GO:0015078 proton transmembrane transporter activity
GO:0016021 integral component of membrane
GO:0016241 regulation of macroautophagy
GO:0016324 apical plasma membrane
GO:0033180 proton-transporting V-type ATPase, V1 domain
GO:0033572 transferrin transport
GO:0034198 cellular response to amino acid starvation
GO:0034220 ion transmembrane transport
GO:0042470 melanosome
GO:0043231 intracellular membrane-bounded organelle
GO:0046034 ATP metabolic process
GO:0046961 proton-transporting ATPase activity, rotational mechanism
GO:0070062 extracellular exosome
GO:0090383 phagosome acidification
GO:1902600 proton transmembrane transport

Subcellular Location

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Subcellular Location
Apical cell membrane
Cytoplasm
Melanosome

Domains

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DomainNameCategoryType
IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domainDomainDomain
IPR004100 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domainDomainDomain
IPR005723 ATPase, V1 complex, subunit BFamilyFamily
IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active siteSiteActive site
IPR022879 V-type ATP synthase regulatory subunit B/betaFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01133 Tiludronic acidDrugbanksmall molecule
DB05260 Gallium nitrateDrugbanksmall molecule
DB07347 4-(2-Aminoethyl)Benzenesulfonyl FluorideDrugbanksmall molecule