Entity Details

Primary name NF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21359
EntryNameNF1_HUMAN
FullNameNeurofibromin
TaxID9606
Evidenceevidence at protein level
Length2839
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesNF1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001649 osteoblast differentiation
GO:0001656 metanephros development
GO:0001666 response to hypoxia
GO:0001889 liver development
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001952 regulation of cell-matrix adhesion
GO:0005096 GTPase activator activity
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006469 negative regulation of protein kinase activity
GO:0007154 cell communication
GO:0007265 Ras protein signal transduction
GO:0007406 negative regulation of neuroblast proliferation
GO:0007420 brain development
GO:0007422 peripheral nervous system development
GO:0007507 heart development
GO:0008429 phosphatidylethanolamine binding
GO:0008542 visual learning
GO:0014044 Schwann cell development
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0021510 spinal cord development
GO:0021897 forebrain astrocyte development
GO:0021987 cerebral cortex development
GO:0022011 myelination in peripheral nervous system
GO:0030036 actin cytoskeleton organization
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0030325 adrenal gland development
GO:0030336 negative regulation of cell migration
GO:0030424 axon
GO:0030425 dendrite
GO:0031210 phosphatidylcholine binding
GO:0042060 wound healing
GO:0043065 positive regulation of apoptotic process
GO:0043087 regulation of GTPase activity
GO:0043407 negative regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0043473 pigmentation
GO:0043525 positive regulation of neuron apoptotic process
GO:0043535 regulation of blood vessel endothelial cell migration
GO:0043547 positive regulation of GTPase activity
GO:0045124 regulation of bone resorption
GO:0045685 regulation of glial cell differentiation
GO:0045762 positive regulation of adenylate cyclase activity
GO:0045765 regulation of angiogenesis
GO:0048147 negative regulation of fibroblast proliferation
GO:0048485 sympathetic nervous system development
GO:0048593 camera-type eye morphogenesis
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0048745 smooth muscle tissue development
GO:0048844 artery morphogenesis
GO:0048853 forebrain morphogenesis
GO:0050890 cognition

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001251 CRAL-TRIO lipid binding domainDomainDomain
IPR001936 Ras GTPase-activating domainDomainDomain
IPR008936 Rho GTPase activation proteinFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR023152 Ras GTPase-activating protein, conserved siteSiteConserved site
IPR036865 CRAL-TRIO lipid binding domain superfamilyFamilyHomologous superfamily
IPR039360 Ras GTPase-activating proteinFamilyFamily

Diseases

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Interactions

86 interactions

InteractorPartnerSourcesPublicationsLink
NF1_HUMANSDC2_HUMANBioGRID, HPRD, IntAct11356864 details
NF1_HUMANA4_HUMANBioGRID, HPRD, IntAct16374483 details
NF1_HUMANSPRE1_HUMANBioGRID, IntAct26635368 27313208 details
NF1_HUMANRASH_HUMANBioGRID, HPRD, IntAct26635368 30639242 30655611 8628317 details
NF1_HUMANTERA_HUMANBioGRID22105171 details
NF1_HUMANFAF2_HUMANBioGRID20160012 26186194 details
NF1_HUMAN5HT6R_HUMANBioGRID23027611 27791021 details
NF1_HUMANCLK1_HUMANBioGRID26167880 details
NF1_HUMANRASN_HUMANBioGRID30194290 7499408 details
NF1_HUMANLIMK2_HUMANBioGRID23082153 details
NF1_HUMANAKT1_HUMANBioGRID28205554 details
NF1_HUMANEPHA2_HUMANBioGRID28205554 details
NF1_HUMANMP2K3_HUMANBioGRID28205554 details
NF1_HUMANRAF1_HUMANBioGRID28205554 details
NF1_HUMANSOX4_HUMANBioGRID28205554 details
NF1_HUMANSUMO1_HUMANMINT17036045 details
NF1_HUMANDYHC1_HUMANMINT23583712 details
NF1_HUMANPML_HUMANBioGRID, IntAct22293200 details
NF1_HUMANDCLK1_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANSI1L1_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANKIF1C_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANSRGP2_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANGGYF1_HUMANIntActunassigned1312 details
NF1_HUMANNADK_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANRTKN_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANOSBL6_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANSIN1_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANSH3R3_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANDEN1A_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANKSR1_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANPHLB2_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANMYCPP_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANAN34A_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANDEN4C_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANSPD2A_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANM3K21_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANPTN14_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANZN638_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANTIAM1_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANPTN13_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANCAMP2_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANCDK16_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANMPIP3_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANMPIP2_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANIF4E2_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANMAST3_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANKCTD3_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANGAB2_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANPPM1H_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANFA53C_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANINP5E_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANTANC2_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANLPIN3_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANHDAC4_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANPKHA7_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANGGYF2_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANSYDE1_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANRGPS2_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANNAV1_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANF110B_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANSRS12_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANMAGI1_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANTESK2_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANKI13B_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANLRFN1_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANCING_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANLIMA1_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANNGAP_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANUBP21_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANZBT21_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANAGAP1_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANCBY1_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMANSTA13_HUMANBioGRID, IntAct27173435 unassigned1312 details
NF1_HUMAN1433F_HUMANBioGRID, IntAct14741381 28514442 details
NF1_HUMANEFS_HUMANMINT21653829 details
NF1_HUMANSMCA4_HUMANBioGRID15999204 details
NF1_HUMANRPB1_HUMANBioGRID15999204 details
NF1_HUMANNSF1C_HUMANBioGRID22105171 details
NF1_HUMANCAV1_HUMANBioGRID16405917 details
NF1_HUMANTRAF6_HUMANBioGRID27507811 details
NF1_HUMANLZTR1_HUMANBioGRID30442766 details
NF1_HUMANFA12_HUMANBioGRID30705246 details
NF1_HUMANTBPL1_HUMANHPRD15767669 details
NF1_HUMANNMDE4_HUMANHPRD10862698 details
NF1_HUMANDNJC7_HUMANHPRD8836031 details
NF1_HUMANNMDZ1_HUMANHPRD10862698 details