Entity Details

Primary name EPHA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21709
EntryNameEPHA1_HUMAN
FullNameEphrin type-A receptor 1
TaxID9606
Evidenceevidence at protein level
Length976
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesEPHA1

GO terms

Show/Hide Table
GOName
GO:0001525 angiogenesis
GO:0001954 positive regulation of cell-matrix adhesion
GO:0001968 fibronectin binding
GO:0004672 protein kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006469 negative regulation of protein kinase activity
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007411 axon guidance
GO:0008284 positive regulation of cell population proliferation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019901 protein kinase binding
GO:0030335 positive regulation of cell migration
GO:0030336 negative regulation of cell migration
GO:0033674 positive regulation of kinase activity
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035019 somatic stem cell population maintenance
GO:0043005 neuron projection
GO:0043087 regulation of GTPase activity
GO:0043235 receptor complex
GO:0045766 positive regulation of angiogenesis
GO:0046777 protein autophosphorylation
GO:0048013 ephrin receptor signaling pathway
GO:0051496 positive regulation of stress fiber assembly
GO:0090630 activation of GTPase activity

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001090 Ephrin receptor ligand binding domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001426 Tyrosine-protein kinase, receptor class V, conserved siteSiteConserved site
IPR001660 Sterile alpha motif domainDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016257 Ephrin receptor type-A /type-BFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR027936 Ephrin receptor, transmembrane domainDomainDomain
IPR034251 Ephrin type-A receptor 1, ligand binding domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

54 interactions

InteractorPartnerSourcesPublicationsLink
EPHA1_HUMANSHIP2_HUMANDIP22244754 details
EPHA1_HUMANDAPK1_HUMANBioGRID, IntAct29513927 details
EPHA1_HUMANCTDS2_HUMANBioGRID, MINT28065597 details
EPHA1_HUMANPTN11_HUMANBioGRID, MINT28065597 details
EPHA1_HUMANDUS14_HUMANBioGRID, MINT28065597 details
EPHA1_HUMANTPTE_HUMANBioGRID, MINT28065597 details
EPHA1_HUMANMTMRE_HUMANBioGRID, MINT28065597 details
EPHA1_HUMANM3K1_HUMANBioGRID25260751 details
EPHA1_HUMANSMUF1_HUMANBioGRID20804422 details
EPHA1_HUMANERBB2_HUMANBioGRID30898150 details
EPHA1_HUMANCXB1_HUMANBioGRID30401746 details
EPHA1_HUMANHS90B_HUMANIntAct22939624 details
EPHA1_HUMANZN197_HUMANIntAct31413325 details
EPHA1_HUMANSAHH2_HUMANIntAct31413325 details
EPHA1_HUMANZN460_HUMANIntAct31413325 details
EPHA1_HUMANTRM61_HUMANIntAct31413325 details
EPHA1_HUMANZN441_HUMANIntAct31413325 details
EPHA1_HUMANCOPB_HUMANIntAct31413325 details
EPHA1_HUMANPKHA6_HUMANIntAct31413325 details
EPHA1_HUMANANS1A_HUMANIntAct31413325 details
EPHA1_HUMANFYN_HUMANIntAct31413325 details
EPHA1_HUMANZBT38_HUMANIntAct31413325 details
EPHA1_HUMANBCLA3_HUMANIntAct31413325 details
EPHA1_HUMANLMBL1_HUMANIntAct31413325 details
EPHA1_HUMANSCAI_HUMANIntAct31413325 details
EPHA1_HUMANGSTP1_HUMANIntAct31413325 details
EPHA1_HUMANZN546_HUMANIntAct31413325 details
EPHA1_HUMANZN181_HUMANIntAct31413325 details
EPHA1_HUMANZN662_HUMANIntAct31413325 details
EPHA1_HUMANP2RX7_HUMANIntAct31413325 details
EPHA1_HUMANPAX6_HUMANIntAct31413325 details
EPHA1_HUMANP85A_HUMANIntAct31413325 details
EPHA1_HUMANSIAE_HUMANIntAct31413325 details
EPHA1_HUMAN2A5A_HUMANIntAct31413325 details
EPHA1_HUMANYETS2_HUMANIntAct31413325 details
EPHA1_HUMANNEUA_HUMANIntAct31413325 details
EPHA1_HUMANZN302_HUMANIntAct31413325 details
EPHA1_HUMANASH1L_HUMANIntAct31413325 details
EPHA1_HUMANSYF1_HUMANIntAct31413325 details
EPHA1_HUMANSHOT1_HUMANIntAct31413325 details
EPHA1_HUMANSHB_HUMANIntAct31413325 details
EPHA1_HUMANRU17_HUMANIntAct31413325 details
EPHA1_HUMANZNF35_HUMANIntAct31413325 details
EPHA1_HUMANZN132_HUMANIntAct31413325 details
EPHA1_HUMANZN133_HUMANIntAct31413325 details
EPHA1_HUMANZNF45_HUMANIntAct31413325 details
EPHA1_HUMANZN606_HUMANIntAct31413325 details
EPHA1_HUMANTNKS2_HUMANIntAct31413325 details
EPHA1_HUMANLMBL2_HUMANIntAct31413325 details
EPHA1_HUMANDGKZ_HUMANIntAct31413325 details
EPHA1_HUMANTNKS1_HUMANIntAct31413325 details
EPHA1_HUMANALK_HUMANBioGRID14968112 details
EPHA1_HUMANEFNA1_HUMANHPRD11519828 8755474 details
EPHA1_HUMANSMUF2_HUMANHPRD15761153 details