Entity Details

Primary name NDKB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP22392
EntryNameNDKB_HUMAN
FullNameNucleoside diphosphate kinase B
TaxID9606
Evidenceevidence at protein level
Length152
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0001726 ruffle
GO:0002762 negative regulation of myeloid leukocyte differentiation
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0004550 nucleoside diphosphate kinase activity
GO:0004673 protein histidine kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005504 fatty acid binding
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006183 GTP biosynthetic process
GO:0006228 UTP biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0007155 cell adhesion
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0009142 nucleoside triphosphate biosynthetic process
GO:0010976 positive regulation of neuron projection development
GO:0015949 nucleobase-containing small molecule interconversion
GO:0019003 GDP binding
GO:0019215 intermediate filament binding
GO:0019899 enzyme binding
GO:0030027 lamellipodium
GO:0031966 mitochondrial membrane
GO:0034599 cellular response to oxidative stress
GO:0034774 secretory granule lumen
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043312 neutrophil degranulation
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045682 regulation of epidermis development
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051880 G-quadruplex DNA binding
GO:0060416 response to growth hormone
GO:0070062 extracellular exosome
GO:0071333 cellular response to glucose stimulus
GO:0071398 cellular response to fatty acid
GO:0071944 cell periphery
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001564 Nucleoside diphosphate kinaseFamilyFamily
IPR023005 Nucleoside diphosphate kinase, active siteSiteActive site
IPR034907 Nucleoside diphosphate kinase-like domainDomainDomain
IPR036850 Nucleoside diphosphate kinase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00300 Tenofovir disoproxilDrugbanksmall molecule
DB00709 LamivudineDrugbanksmall molecule
DB00718 Adefovir dipivoxilDrugbanksmall molecule
DB00787 AcyclovirDrugbanksmall molecule
DB01262 DecitabineDrugbanksmall molecule
DB04315 Guanosine-5'-DiphosphateDrugbanksmall molecule
DB09299 Tenofovir alafenamideDrugbanksmall molecule
DB14126 TenofovirDrugbanksmall molecule

Interactions

74 interactions

InteractorPartnerSourcesPublicationsLink
NDKB_HUMANNDK3_HUMANBioGRID, HPRD, IntAct11042679 16169070 28514442 details
NDKB_HUMANITBP1_HUMANIntAct11919189 details
NDKB_HUMANNDKA_HUMANBioGRID, IntAct17314099 21988832 22863883 31980649 details
NDKB_HUMANRHOB_HUMANIntAct19637314 details
NDKB_HUMANCTBP1_HUMANBioGRID, IntAct21988832 details
NDKB_HUMANRAB5A_HUMANBioGRID, IntAct21988832 details
NDKB_HUMANGIT2_HUMANBioGRID, IntAct21988832 details
NDKB_HUMANNDKM_HUMANBioGRID, IntAct21988832 27499296 details
NDKB_HUMANBNIPL_HUMANBioGRID, IntAct21988832 details
NDKB_HUMANNDKB_HUMANBioGRID, HPRD, IntAct21988832 31980649 7658474 8245015 details
NDKB_HUMANDYN2_HUMANDIP24970086 details
NDKB_HUMANHERC3_HUMANBioGRID18535780 details
NDKB_HUMANHERC5_HUMANBioGRID, HPRD18535780 details
NDKB_HUMANHERC6_HUMANBioGRID18535780 details
NDKB_HUMANSVIL_HUMANBioGRID, HPRD20309963 details
NDKB_HUMANMDM2_HUMANBioGRID21504894 details
NDKB_HUMANTA2R_HUMANBioGRID, HPRD14976202 details
NDKB_HUMANTERF1_HUMANHPRD9480811 details
NDKB_HUMANRORA_HUMANHPRD8858107 details
NDKB_HUMANPP1R7_HUMANBioGRID, IntAct17353931 details
NDKB_HUMANKVD28_HUMANIntAct17353931 details
NDKB_HUMAN5HT1B_HUMANBioGRID, IntAct17353931 details
NDKB_HUMANPP1R8_HUMANBioGRID, IntAct17353931 details
NDKB_HUMANRPAB3_HUMANBioGRID, IntAct17353931 details
NDKB_HUMANH2B1C_HUMANBioGRID, IntAct17353931 details
NDKB_HUMANCYBP_HUMANIntAct17353931 details
NDKB_HUMANPGRC1_HUMANIntAct17353931 details
NDKB_HUMANRL38_HUMANBioGRID, IntAct17353931 details
NDKB_HUMANKAD2_HUMANBioGRID, IntAct17353931 26344197 details
NDKB_HUMANUBE2N_HUMANIntAct17353931 details
NDKB_HUMANINO1_HUMANIntAct17353931 details
NDKB_HUMANG3BP1_HUMANIntAct17353931 details
NDKB_HUMANSET_HUMANIntAct17353931 details
NDKB_HUMANPSA2_HUMANBioGRID, IntAct17353931 details
NDKB_HUMANSTRAP_HUMANIntAct17353931 details
NDKB_HUMANUBE2K_HUMANIntAct17353931 details
NDKB_HUMANCBR1_HUMANIntAct17353931 details
NDKB_HUMANLYSC_HUMANBioGRID, IntAct17353931 details
NDKB_HUMANRS19_HUMANIntAct17353931 details
NDKB_HUMANPDIA6_HUMANBioGRID, IntAct17353931 details
NDKB_HUMANRS16_HUMANIntAct17353931 details
NDKB_HUMANPSD12_HUMANIntAct17353931 details
NDKB_HUMANLA_HUMANIntAct17353931 details
NDKB_HUMANRTN4_HUMANIntAct17353931 details
NDKB_HUMAN2AAA_HUMANIntAct17353931 details
NDKB_HUMANPCBP1_HUMANIntAct17353931 details
NDKB_HUMANRPN2_HUMANIntAct17353931 details
NDKB_HUMANEPIPL_HUMANBioGRID, IntAct17353931 details
NDKB_HUMANACLY_HUMANBioGRID, IntAct17353931 27664236 details
NDKB_HUMANRNBP6_HUMANIntAct17353931 details
NDKB_HUMANLSM2_HUMANIntAct17353931 details
NDKB_HUMANMGN_HUMANIntAct17353931 details
NDKB_HUMANRRP44_HUMANIntAct17353931 details
NDKB_HUMANSTIP1_HUMANBioGRID, IntAct17353931 26344197 details
NDKB_HUMANRD23A_HUMANIntAct17353931 details
NDKB_HUMANPSA7_HUMANBioGRID, IntAct17353931 details
NDKB_HUMANF10A1_HUMANIntAct17353931 details
NDKB_HUMANPA1B2_HUMANIntAct17353931 details
NDKB_HUMANDYHC1_HUMANBioGRID, IntAct17353931 details
NDKB_HUMANPSB4_HUMANIntAct17353931 details
NDKB_HUMANRUVB2_HUMANBioGRID, IntAct17353931 details
NDKB_HUMANEIF3M_HUMANIntAct17353931 details
NDKB_HUMANPUR9_HUMANBioGRID, IntAct17353931 details
NDKB_HUMANKINH_HUMANBioGRID, IntAct17353931 details
NDKB_HUMAN1433Z_HUMANMINT15161933 details
NDKB_HUMANPRKN_HUMANBioGRID, UniProt23068103 25959826 details
NDKB_HUMANESR1_HUMANBioGRID, IntAct23576398 31527615 details
NDKB_HUMANFXR1_HUMANMINT21653829 details
NDKB_HUMANVIME_HUMANBioGRID, HPRD11082283 details
NDKB_HUMANHYPK_HUMANBioGRID23272104 details
NDKB_HUMANPTPRS_HUMANBioGRID26896769 details
NDKB_HUMANPP2AA_HUMANHPRD17163575 details
NDKB_HUMANDYN1_HUMANHPRD11872741 details
NDKB_HUMANPHOCN_HUMANHPRD11872741 details