Entity Details

Primary name ROA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP22626
EntryNameROA2_HUMAN
FullNameHeterogeneous nuclear ribonucleoproteins A2/B1
TaxID9606
Evidenceevidence at protein level
Length353
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesHNRNPA2B1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000398 mRNA splicing, via spliceosome
GO:0000781 chromosome, telomeric region
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0006397 mRNA processing
GO:0006406 mRNA export from nucleus
GO:0015030 Cajal body
GO:0016020 membrane
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016363 nuclear matrix
GO:0031053 primary miRNA processing
GO:0035198 miRNA binding
GO:0035722 interleukin-12-mediated signaling pathway
GO:0042802 identical protein binding
GO:0043047 single-stranded telomeric DNA binding
GO:0044806 G-quadruplex DNA unwinding
GO:0048025 negative regulation of mRNA splicing, via spliceosome
GO:0050658 RNA transport
GO:0070062 extracellular exosome
GO:0071013 catalytic step 2 spliceosome
GO:0097157 pre-mRNA intronic binding
GO:0098505 G-rich strand telomeric DNA binding
GO:1904358 positive regulation of telomere maintenance via telomere lengthening
GO:1905663 positive regulation of telomerase RNA reverse transcriptase activity
GO:1990247 N6-methyladenosine-containing RNA binding
GO:1990428 miRNA transport
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic granule
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR000504 RNA recognition motif domainDomainDomain
IPR012677 Nucleotide-binding alpha-beta plait domain superfamilyFamilyHomologous superfamily
IPR034486 hnRNP A2/B1, RNA recognition motif 1DomainDomain
IPR034489 hnRNP A2/B1FamilyFamily
IPR035979 RNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615422 OMIMInclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 2 (IBMPFD2)An autosomal dominant disease characterized by disabling muscle weakness clinically resembling to limb girdle muscular dystrophy, osteolytic bone lesions consistent with Paget disease, and premature frontotemporal dementia. Clinical features show incomplete penetrance. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB09130 CopperDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule

Interactions

59 interactions

InteractorPartnerSourcesPublicationsLink
ROA2_HUMANYAE1_HUMANBioGRID, MINT21900206 details
ROA2_HUMANCDN2A_HUMANBioGRID, IntAct17955473 details
ROA2_HUMANROA2_HUMANDIP, MINT15518812 23455423 details
ROA2_HUMANM4K2_HUMANBioGRID, MINT21900206 details
ROA2_HUMANCSK21_HUMANBioGRID, HPRD, IntAct10381337 22113938 details
ROA2_HUMANRBM3_HUMANMINT15518812 details
ROA2_HUMANESR1_HUMANBioGRID, IntAct20348541 21182205 details
ROA2_HUMANNR4A1_HUMANBioGRID, MINT21900206 details
ROA2_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
ROA2_HUMANHNRPL_HUMANBioGRID, DIP, HPRD10441480 22939629 23976881 28611215 details
ROA2_HUMANARF_HUMANBioGRID17955473 details
ROA2_HUMANERG_HUMANBioGRID21575865 24591637 details
ROA2_HUMANARI4B_HUMANBioGRID32296183 details
ROA2_HUMANH31T_HUMANBioGRID20850016 details
ROA2_HUMANCSK2B_HUMANBioGRID10381337 details
ROA2_HUMANSREK1_HUMANBioGRID, HPRD14559993 details
ROA2_HUMANTPC12_HUMANBioGRID32296183 details
ROA2_HUMANMCPH1_HUMANBioGRID29150431 details
ROA2_HUMANPSA3_HUMANBioGRID22079093 30009671 details
ROA2_HUMANSTA5B_HUMANBioGRID32296183 details
ROA2_HUMANDNLI4_HUMANBioGRID22990118 details
ROA2_HUMANENY2_HUMANBioGRID32296183 details
ROA2_HUMANSUMO2_HUMANBioGRID32786267 details
ROA2_HUMANTRI35_HUMANBioGRID32296183 details
ROA2_HUMANOGT1_HUMANBioGRID32994395 details
ROA2_HUMANZMYM2_HUMANBioGRID, HPRD, MINT15975576 details
ROA2_HUMANSF3A2_HUMANBioGRID, MINT17332742 details
ROA2_HUMANZMAT3_HUMANBioGRID, MINT18519039 details
ROA2_HUMANTOB1_HUMANUniProt18377426 details
ROA2_HUMANVHL_HUMANBioGRID, HPRD11517223 21942715 23976881 27473082 32826868 details
ROA2_HUMANMAX_HUMANIntAct20195357 details
ROA2_HUMANDHX9_HUMANMINT18519039 details
ROA2_HUMANTADBP_HUMANBioGRID, DIP19383787 20020773 25678563 details
ROA2_HUMANNFX1_HUMANBioGRID17267499 details
ROA2_HUMANITA4_HUMANBioGRID22623428 details
ROA2_HUMANILF3_HUMANBioGRID, DIP23976881 29395067 details
ROA2_HUMANIF2B3_HUMANBioGRID22863883 29212181 details
ROA2_HUMANCTNB1_HUMANBioGRID16230076 27684187 details
ROA2_HUMANMGMT_HUMANBioGRID16226712 details
ROA2_HUMANNDUF8_HUMANBioGRID28162770 details
ROA2_HUMANPHF6_HUMANBioGRID22720776 details
ROA2_HUMANSRRM2_HUMANBioGRID16159877 details
ROA2_HUMANSOX2_HUMANBioGRID21280222 details
ROA2_HUMANMAEL_HUMANBioGRID24189637 details
ROA2_HUMANHDAC5_HUMANBioGRID21081666 details
ROA2_HUMANPPIA_HUMANBioGRID25678563 details
ROA2_HUMAN1433T_HUMANBioGRID20618440 details
ROA2_HUMANNPM_HUMANBioGRID25349213 details
ROA2_HUMANXRN2_HUMANBioGRID29395067 details
ROA2_HUMANMBNL1_HUMANBioGRID21900255 details
ROA2_HUMANCDC37_HUMANBioGRID16611982 details
ROA2_HUMANNXF1_HUMANBioGRID22658674 29395067 details
ROA2_HUMANRU17_HUMANBioGRID, HPRD1833625 29802200 details
ROA2_HUMANU2AF2_HUMANBioGRID26641092 details
ROA2_HUMANPABP1_HUMANBioGRID29395067 details
ROA2_HUMANPA2G4_HUMANBioGRID19037095 details
ROA2_HUMANEP300_HUMANBioGRID26774881 details
ROA2_HUMANFGF11_HUMANBioGRID28027390 details
ROA2_HUMANSPTA1_HUMANBioGRID16889989 details