Entity Details

Primary name MMP8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP22894
EntryNameMMP8_HUMAN
FullNameNeutrophil collagenase
TaxID9606
Evidenceevidence at protein level
Length467
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesMMP8

GO terms

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GOName
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006508 proteolysis
GO:0008233 peptidase activity
GO:0008270 zinc ion binding
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0032693 negative regulation of interleukin-10 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0035580 specific granule lumen
GO:0035987 endodermal cell differentiation
GO:0043312 neutrophil degranulation
GO:0043388 positive regulation of DNA binding
GO:0043410 positive regulation of MAPK cascade
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0046330 positive regulation of JNK cascade
GO:0062023 collagen-containing extracellular matrix
GO:0150077 regulation of neuroinflammatory response
GO:0150078 positive regulation of neuroinflammatory response
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1903428 positive regulation of reactive oxygen species biosynthetic process
GO:1903978 regulation of microglial cell activation
GO:1903980 positive regulation of microglial cell activation
GO:1904724 tertiary granule lumen

Subcellular Location

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Subcellular Location
Cytoplasmic granule
Secreted

Domains

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DomainNameCategoryType
IPR000585 Hemopexin-like domainDomainDomain
IPR001818 Peptidase M10, metallopeptidaseDomainDomain
IPR002477 Peptidoglycan binding-likeDomainDomain
IPR006026 Peptidase, metallopeptidaseDomainDomain
IPR018486 Hemopexin, conserved siteSiteConserved site
IPR018487 Hemopexin-like repeatsRepeatRepeat
IPR021158 Peptidase M10A, cysteine switch, zinc binding siteSiteBinding site
IPR021190 Peptidase M10AFamilyFamily
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR028709 Neutrophil collagenaseFamilyFamily
IPR033739 Peptidase M10A, catalytic domainDomainDomain
IPR036365 PGBD-like superfamilyFamilyHomologous superfamily
IPR036366 PGBD superfamilyFamilyHomologous superfamily
IPR036375 Hemopexin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00786 MarimastatDrugbanksmall molecule
DB02326 1-Hydroxyamine-2-Isobutylmalonic AcidDrugbanksmall molecule
DB02953 2-Thiomethyl-3-Phenylpropanoic AcidDrugbanksmall molecule
DB03207 2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic AcidDrugbanksmall molecule
DB03622 5-[4-(2-Hydroxyethyl)-1-piperidinyl]-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrioneDrugbanksmall molecule
DB03636 GlycinamideDrugbanksmall molecule
DB03880 BatimastatDrugbanksmall molecule
DB06971 N-{2-[(4'-CYANO-1,1'-BIPHENYL-4-YL)OXY]ETHYL}-N'-HYDROXY-N-METHYLUREADrugbanksmall molecule
DB07397 (5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidine-2-carboxamideDrugbanksmall molecule
DB07713 (1S)-1-{[(4'-methoxy-1,1'-biphenyl-4-yl)sulfonyl]amino}-2-methylpropylphosphonic acidDrugbanksmall molecule
DB07772 (1R)-1-{[(4'-methoxy-1,1'-biphenyl-4-yl)sulfonyl]amino}-2-methylpropylphosphonic acidDrugbanksmall molecule
DB07900 3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACID HYDROXYAMIDEDrugbanksmall molecule
DB08028 BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHYDRO-[1,3,4]THIADIAZIN-2-YLIDENE]-AMINEDrugbanksmall molecule
DB08403 METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACIDDrugbanksmall molecule
DB08476 3-AMINO-AZACYCLOTRIDECAN-2-ONEDrugbanksmall molecule