Entity Details

Primary name JAK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23458
EntryNameJAK1_HUMAN
FullNameTyrosine-protein kinase JAK1
TaxID9606
Evidenceevidence at protein level
Length1154
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesJAK1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005131 growth hormone receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0006468 protein phosphorylation
GO:0016020 membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031730 CCR5 chemokine receptor binding
GO:0034112 positive regulation of homotypic cell-cell adhesion
GO:0035556 intracellular signal transduction
GO:0035722 interleukin-12-mediated signaling pathway
GO:0035723 interleukin-15-mediated signaling pathway
GO:0038110 interleukin-2-mediated signaling pathway
GO:0038111 interleukin-7-mediated signaling pathway
GO:0038113 interleukin-9-mediated signaling pathway
GO:0038114 interleukin-21-mediated signaling pathway
GO:0046677 response to antibiotic
GO:0046872 metal ion binding
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070106 interleukin-27-mediated signaling pathway
GO:0070757 interleukin-35-mediated signaling pathway
GO:0150105 protein localization to cell-cell junction
GO:1903672 positive regulation of sprouting angiogenesis

Subcellular Location

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Subcellular Location
Endomembrane system

Domains

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DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR019748 FERM central domainDomainDomain
IPR019749 Band 4.1 domainDomainDomain
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR020776 Tyrosine-protein kinase, non-receptor Jak1FamilyFamily
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR041046 JAK, FERM F2 lobe domainDomainDomain
IPR041155 FERM F1 lobe ubiquitin-like domainDomainDomain
IPR041381 Jak1, pleckstrin homology-like domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB02375 MyricetinDrugbanksmall molecule
DB04716 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-oneDrugbanksmall molecule
DB08877 RuxolitinibDrugbanksmall molecule
DB08895 TofacitinibDrugbanksmall molecule
DB11817 BaricitinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12500 FedratinibDrugbanksmall molecule
DB14845 FilgotinibDrugbanksmall molecule
DB15091 UpadacitinibDrugbanksmall molecule
DB15822 PralsetinibDrugbanksmall molecule

Interactions

93 interactions

InteractorPartnerSourcesPublicationsLink
JAK1_HUMANSTAM2_HUMANBioGRID, HPRD, MINT10899310 10993906 details
JAK1_HUMANERBB2_HUMANBioGRID, MINT16273093 details
JAK1_HUMANINAR2_HUMANBioGRID, HPRD, MINT12133952 16710296 29997210 details
JAK1_HUMANSTAT3_HUMANBioGRID, DIP, HPRD, IntAct10918587 11294897 11350938 11722592 11751884 11940572 12244095 12576423 12626508 14551213 15284024 25065853 31462771 8272872 8626374 9566874 details
JAK1_HUMANJAK2_HUMANBioGRID, IntAct26175413 32001089 details
JAK1_HUMANIL4RA_HUMANBioGRID, HPRD, IntAct12133952 12242343 28514442 details
JAK1_HUMANINGR1_HUMANBioGRID, HPRD, IntAct12133952 21689637 28514442 details
JAK1_HUMANIL6RB_HUMANBioGRID, DIP, HPRD11468294 11742534 21220115 9388212 details
JAK1_HUMANAGTR1_HUMANBioGRID, MINT28298427 details
JAK1_HUMANSTAT1_HUMANBioGRID, HPRD, IntAct10918587 10982844 11294897 11722592 11839738 12637327 12817007 14978237 15284024 15322115 32123171 32814877 32953130 7543024 7657660 7690989 details
JAK1_HUMANABL1_HUMANBioGRID, HPRD12130510 9774693 details
JAK1_HUMANRACK1_HUMANBioGRID, HPRD12960323 22558273 details
JAK1_HUMANANM5_HUMANBioGRID, HPRD10531356 details
JAK1_HUMANSHB_HUMANBioGRID, HPRD12200137 details
JAK1_HUMANI10R1_HUMANBioGRID, HPRD10433356 12133952 12374810 details
JAK1_HUMANIRS1_HUMANBioGRID, HPRD11162588 7499365 9492017 details
JAK1_HUMANIGF1R_HUMANBioGRID, HPRD9492017 details
JAK1_HUMANIL2RB_HUMANBioGRID, HPRD12133952 20816854 7973658 7973659 8041779 8700888 9553136 9774657 details
JAK1_HUMANPTN11_HUMANBioGRID, HPRD11036942 12270932 12403768 8995399 9794795 details
JAK1_HUMANTNR1A_HUMANBioGRID, HPRD11801527 9510175 details
JAK1_HUMANSTA5B_HUMANBioGRID9047382 details
JAK1_HUMANSTA5A_HUMANBioGRID, HPRD11722592 9047382 details
JAK1_HUMANELP2_HUMANBioGRID, HPRD10954736 details
JAK1_HUMANGRB2_HUMANBioGRID, HPRD11527382 8536716 details
JAK1_HUMANPTN6_HUMANBioGRID, HPRD7629131 9520455 details
JAK1_HUMANH31T_HUMANBioGRID21151131 details
JAK1_HUMANSOCS1_HUMANBioGRID, HPRD10707961 11133764 29674694 29991678 details
JAK1_HUMANSOCS3_HUMANBioGRID, HPRD10373548 10707961 details
JAK1_HUMANTOP1_HUMANBioGRID12549820 details
JAK1_HUMANSTAT6_HUMANBioGRID, HPRD10856136 9651359 details
JAK1_HUMANJAK1_HUMANBioGRID, HPRD32001089 8041779 9597132 details
JAK1_HUMANJAK3_HUMANBioGRID, HPRD12207328 12559972 32001089 9553136 details
JAK1_HUMANUBP6_HUMANBioGRID27440725 details
JAK1_HUMANGAB1_HUMANBioGRID9632795 details
JAK1_HUMANBRCA1_HUMANBioGRID, HPRD, MINT11163768 details
JAK1_HUMANIL6RA_HUMANMINT11557047 details
JAK1_HUMANKPCA_HUMANMINT17290288 details
JAK1_HUMANHS90B_HUMANIntAct22939624 details
JAK1_HUMANIL3RB_HUMANBioGRID, HPRD, IntAct11557047 15194700 21965659 9516124 details
JAK1_HUMANOSMR_HUMANBioGRID, HPRD, IntAct10586060 28514442 details
JAK1_HUMANFYN_HUMANIntAct31413325 details
JAK1_HUMANABL2_HUMANBioGRID9774693 details
JAK1_HUMANI27RA_HUMANBioGRID12734330 details
JAK1_HUMANFAK2_HUMANBioGRID, HPRD10702271 details
JAK1_HUMANTEC_HUMANBioGRID, HPRD9178903 details
JAK1_HUMANBTK_HUMANBioGRID, HPRD9178903 details
JAK1_HUMANTYK2_HUMANBioGRID, HPRD7589562 8702790 details
JAK1_HUMANIRS2_HUMANBioGRID, HPRD7499365 details
JAK1_HUMANIL21R_HUMANBioGRID, HPRD11016959 11418623 details
JAK1_HUMANCSF3R_HUMANBioGRID, HPRD7512720 details
JAK1_HUMANIL9R_HUMANBioGRID, HPRD8756628 details
JAK1_HUMANUPAR_HUMANBioGRID, HPRD9417082 details
JAK1_HUMANTSHR_HUMANBioGRID, HPRD10809230 details
JAK1_HUMANGHR_HUMANBioGRID, HPRD10502458 details
JAK1_HUMANRAF1_HUMANBioGRID, HPRD9446616 details
JAK1_HUMANSIR1_HUMANBioGRID22542455 details
JAK1_HUMANIL2RG_HUMANBioGRID, HPRD7973658 8041779 details
JAK1_HUMANE2AK2_HUMANBioGRID, HPRD17290288 details
JAK1_HUMANHS90A_HUMANBioGRID22939624 details
JAK1_HUMANINSR_HUMANBioGRID, HPRD12456798 9492017 details
JAK1_HUMANPLCG1_HUMANBioGRID14978237 details
JAK1_HUMANPA24A_HUMANBioGRID, HPRD8612580 details
JAK1_HUMANMDM2_HUMANBioGRID24413661 27362806 details
JAK1_HUMANNOC2L_HUMANBioGRID24413661 details
JAK1_HUMANPML_HUMANBioGRID20409569 details
JAK1_HUMANTAGL_HUMANBioGRID22798525 details
JAK1_HUMANDTX3L_HUMANBioGRID24886089 details
JAK1_HUMANRN125_HUMANBioGRID26027934 details
JAK1_HUMANCFTR_HUMANBioGRID27261451 details
JAK1_HUMANKPCZ_HUMANBioGRID, HPRD15526032 29491746 details
JAK1_HUMANPARP9_HUMANBioGRID23487038 details
JAK1_HUMANSYVN1_HUMANBioGRID32456827 details
JAK1_HUMANISG15_HUMANBioGRID33024031 details
JAK1_HUMANSTAM1_HUMANHPRD9133424 details
JAK1_HUMANPLCG2_HUMANHPRD14978237 details
JAK1_HUMANCXCR4_HUMANHPRD12163560 details
JAK1_HUMANCCR1_HUMANHPRD14674010 details
JAK1_HUMANCCR5_HUMANHPRD10037796 details
JAK1_HUMANIL7RA_HUMANHPRD15996891 8647212 details
JAK1_HUMANPGFRB_HUMANHPRD8657151 9484840 details
JAK1_HUMANPGFRA_HUMANHPRD11468294 details
JAK1_HUMANFES_HUMANHPRD11160325 details
JAK1_HUMANIL3RA_HUMANHPRD15988755 details
JAK1_HUMANSHIP1_HUMANHPRD10875931 details
JAK1_HUMANSH2B2_HUMANHPRD11751854 details
JAK1_HUMANJKIP1_HUMANHPRD15277531 details
JAK1_HUMANPTPRC_HUMANHPRD11201744 details
JAK1_HUMANMK_HUMANHPRD9452495 details
JAK1_HUMANP85A_HUMANHPRD9774657 details
JAK1_HUMANFER_HUMANHPRD12738762 details
JAK1_HUMANKSYK_HUMANHPRD10825200 details
JAK1_HUMANSTAT2_HUMANHPRD9020188 details
JAK1_HUMANPTN2_HUMANHPRD11909529 15588985 details