Entity Details

Primary name IL4RA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP24394
EntryNameIL4RA_HUMAN
FullNameInterleukin-4 receptor subunit alpha
TaxID9606
Evidenceevidence at protein level
Length825
SequenceStatuscomplete
DateCreated1992-03-01
DateModified2021-06-02

Ontological Relatives

GenesIL4R

GO terms

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GOName
GO:0002532 production of molecular mediator involved in inflammatory response
GO:0002639 positive regulation of immunoglobulin production
GO:0004913 interleukin-4 receptor activity
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006955 immune response
GO:0007165 signal transduction
GO:0016064 immunoglobulin mediated immune response
GO:0019221 cytokine-mediated signaling pathway
GO:0030728 ovulation
GO:0032722 positive regulation of chemokine production
GO:0034451 centriolar satellite
GO:0042127 regulation of cell population proliferation
GO:0042832 defense response to protozoan
GO:0043032 positive regulation of macrophage activation
GO:0043235 receptor complex
GO:0043306 positive regulation of mast cell degranulation
GO:0043627 response to estrogen
GO:0045626 negative regulation of T-helper 1 cell differentiation
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1901741 positive regulation of myoblast fusion
GO:1990834 response to odorant

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR003531 Short hematopoietin receptor, family 1, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015319 Interleukin-4 receptor alpha, N-terminalDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB05078 AER001Drugbanksmall molecule
DB12159 DupilumabDrugbankbiotech

Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
IL4RA_HUMANIL4_HUMANBioGRID, HPRD, IntAct, MINT10219247 11786020 18243101 23597562 8266078 details
IL4RA_HUMANARI2_HUMANBioGRID, HPRD, IntAct16169070 details
IL4RA_HUMANSHIP1_HUMANBioGRID, HPRD, MINT11714803 details
IL4RA_HUMANPTN6_HUMANBioGRID, HPRD, MINT11714803 27742835 9392697 details
IL4RA_HUMANSTAT6_HUMANBioGRID, HPRD, MINT11313257 15661890 8816495 9392697 9651359 details
IL4RA_HUMANIL4RA_HUMANIntAct21058338 details
IL4RA_HUMANJAK1_HUMANBioGRID, HPRD, IntAct12133952 12242343 28514442 details
IL4RA_HUMANIRS1_HUMANHPRD, IntAct8599766 details
IL4RA_HUMANRACK1_HUMANBioGRID, HPRD12960323 details
IL4RA_HUMANSHC1_HUMANBioGRID, HPRD10652211 11714803 details
IL4RA_HUMANPTN11_HUMANBioGRID, HPRD11714803 details
IL4RA_HUMANHGS_HUMANBioGRID21362618 details
IL4RA_HUMANSOCS5_HUMANBioGRID, HPRD12242343 details
IL4RA_HUMANIL13_HUMANBioGRID, HPRD11313257 11709756 22952195 details
IL4RA_HUMANI13R2_HUMANBioGRID22952195 details
IL4RA_HUMANIL2RG_HUMANBioGRID, HPRD, IntAct12242343 18243101 8266076 8266078 details
IL4RA_HUMANI13R1_HUMANHPRD, IntAct18243101 8910586 details
IL4RA_HUMANPIBF1_HUMANUniProt25218441 details
IL4RA_HUMANNCF1_HUMANBioGRID, HPRD10369419 details
IL4RA_HUMANKAT5_HUMANBioGRID10486269 details
IL4RA_HUMANJAK2_HUMANBioGRID, HPRD8609418 details
IL4RA_HUMANJAK3_HUMANBioGRID, HPRD12207328 7538655 details
IL4RA_HUMANTNR5_HUMANBioGRID, HPRD12207328 details
IL4RA_HUMANGRB10_HUMANBioGRID27742835 details
IL4RA_HUMANNED4L_HUMANBioGRID27742835 details
IL4RA_HUMANKPCZ_HUMANHPRD15526032 details
IL4RA_HUMANDOK2_HUMANHPRD10856136 details
IL4RA_HUMANFES_HUMANHPRD7518439 details
IL4RA_HUMANIRS2_HUMANHPRD8954948 details