Entity Details

Primary name DNMT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP26358
EntryNameDNMT1_HUMAN
FullNameDNA (cytosine-5)-methyltransferase 1
TaxID9606
Evidenceevidence at protein level
Length1616
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesDNMT1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003677 DNA binding
GO:0003886 DNA (cytosine-5-)-methyltransferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006306 DNA methylation
GO:0006325 chromatin organization
GO:0007265 Ras protein signal transduction
GO:0008270 zinc ion binding
GO:0009008 DNA-methyltransferase activity
GO:0010216 maintenance of DNA methylation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0045814 negative regulation of gene expression, epigenetic
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0051573 negative regulation of histone H3-K9 methylation
GO:0090309 positive regulation of DNA methylation-dependent heterochromatin assembly
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1905460 negative regulation of vascular associated smooth muscle cell apoptotic process
GO:1905931 negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching
GO:1990841 promoter-specific chromatin binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001025 Bromo adjacent homology (BAH) domainDomainDomain
IPR001525 C-5 cytosine methyltransferaseFamilyFamily
IPR002857 Zinc finger, CXXC-typeDomainDomain
IPR010506 DMAP1-binding domainDomainDomain
IPR017198 DNA (cytosine-5)-methyltransferase 1-likeFamilyFamily
IPR018117 DNA methylase, C-5 cytosine-specific, active siteSiteActive site
IPR022702 DNA (cytosine-5)-methyltransferase 1, replication foci domainDomainDomain
IPR029063 S-adenosyl-L-methionine-dependent methyltransferaseFamilyHomologous superfamily
IPR031303 DNA methylase, C-5 cytosine-specific, conserved siteSiteConserved site
IPR043151 Bromo adjacent homology (BAH) domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00721 ProcaineDrugbanksmall molecule
DB00928 AzacitidineDrugbanksmall molecule
DB01035 ProcainamideDrugbanksmall molecule
DB01099 FlucytosineDrugbanksmall molecule
DB01262 DecitabineDrugbanksmall molecule
DB05668 PalifosfamideDrugbanksmall molecule
DB12116 Epigallocatechin gallateDrugbanksmall molecule

Interactions

116 interactions

InteractorPartnerSourcesPublicationsLink
DNMT1_HUMANTRI27_HUMANBioGRID, HPRD, IntAct16169070 details
DNMT1_HUMANEZH2_HUMANBioGRID, HPRD, IntAct16357870 21378168 22094255 28068325 31130994 details
DNMT1_HUMANUHRF1_HUMANBioGRID, IntAct, MINT17673620 17934516 19798101 19800870 19943104 20613874 21045206 21268065 21745816 22064703 24368767 24782312 26065575 27045799 27049577 28803780 29268763 29691401 31322780 details
DNMT1_HUMANHDAC1_HUMANBioGRID, HPRD, IntAct10615135 10888886 12473678 15870198 17707923 17934516 17967891 20613874 21670149 22274925 23708667 26794444 27593931 details
DNMT1_HUMANNRIP1_HUMANBioGRID, MINT17972916 details
DNMT1_HUMANUBP7_HUMANBioGRID, IntAct19615732 21045206 21268065 21745816 22411829 25753001 25960197 26496610 30367141 30804394 31130994 32884836 details
DNMT1_HUMANKAT2B_HUMANUniProt21947282 details
DNMT1_HUMANSIR1_HUMANBioGRID, IntAct, UniProt21947282 22094255 details
DNMT1_HUMANCSK2B_HUMANBioGRID, MINT21900206 details
DNMT1_HUMANGSK3B_HUMANBioGRID, MINT21900206 details
DNMT1_HUMANKS6A6_HUMANBioGRID, MINT21900206 details
DNMT1_HUMANDNM3B_HUMANBioGRID, HPRD, IntAct12145218 12867029 15120635 21406692 22094255 27728808 29691401 details
DNMT1_HUMANBRAP_HUMANBioGRID, IntAct25820252 details
DNMT1_HUMANSETD7_HUMANBioGRID, DIP19282482 21151116 details
DNMT1_HUMANAKT1_HUMANBioGRID, DIP21151116 details
DNMT1_HUMANH31_HUMANBioGRID, IntAct26527279 29568061 32144273 32884836 34079125 details
DNMT1_HUMANRGS6_HUMANBioGRID14734556 details
DNMT1_HUMANCBX1_HUMANBioGRID, HPRD12711675 details
DNMT1_HUMANPCNA_HUMANBioGRID, HPRD10888872 12354094 20613874 20940144 22606318 23708667 24958773 26496610 30301766 9302295 details
DNMT1_HUMANHDAC2_HUMANBioGRID, HPRD10888872 17967891 21670149 23708667 details
DNMT1_HUMANDMAP1_HUMANBioGRID, HPRD10888872 details
DNMT1_HUMANRB_HUMANBioGRID, HPRD10888886 11847125 23280764 details
DNMT1_HUMANDNM3A_HUMANBioGRID, HPRD12145218 21406692 29691401 details
DNMT1_HUMANMECP2_HUMANBioGRID12473678 details
DNMT1_HUMANBAZ2A_HUMANBioGRID16085498 details
DNMT1_HUMANHELLS_HUMANBioGRID17967891 details
DNMT1_HUMANMTG8_HUMANBioGRID15735013 details
DNMT1_HUMANRUNX1_HUMANBioGRID15735013 28533407 details
DNMT1_HUMANPAF15_HUMANBioGRID21628590 32144273 details
DNMT1_HUMAN1433T_HUMANBioGRID15161933 details
DNMT1_HUMANH31T_HUMANBioGRID26065575 30104358 details
DNMT1_HUMANLASP1_HUMANBioGRID25982273 details
DNMT1_HUMANAAPK2_HUMANBioGRID28143904 details
DNMT1_HUMANCUL4B_HUMANBioGRID24292684 29691401 details
DNMT1_HUMANDDB1_HUMANBioGRID24292684 29691401 details
DNMT1_HUMANE2F6_HUMANBioGRID23082233 details
DNMT1_HUMANUBB_HUMANBioGRID29471350 details
DNMT1_HUMANDCAF5_HUMANBioGRID29691401 details
DNMT1_HUMANLMBL3_HUMANBioGRID29691401 details
DNMT1_HUMANSUMO2_HUMANBioGRID32786267 details
DNMT1_HUMANH2B1B_HUMANBioGRID32884836 details
DNMT1_HUMANTS101_HUMANHPRD10888872 details
DNMT1_HUMANEED_HUMANBioGRID, HPRD, IntAct16357870 22094255 details
DNMT1_HUMAN1433Z_HUMANMINT15161933 details
DNMT1_HUMANH2AX_HUMANIntAct22094255 27728808 details
DNMT1_HUMANCTNB1_HUMANIntAct25753001 details
DNMT1_HUMANPARP1_HUMANBioGRID, IntAct23708667 27728808 34079125 details
DNMT1_HUMANMTA2_HUMANBioGRID, IntAct21670149 23708667 27728808 details
DNMT1_HUMANMTA1_HUMANBioGRID, IntAct21670149 23708667 26344197 27728808 details
DNMT1_HUMANMBD2_HUMANBioGRID, IntAct10947852 27593931 details
DNMT1_HUMANH4_HUMANBioGRID, IntAct30021884 30804502 details
DNMT1_HUMANPICK1_HUMANMINT21653829 details
DNMT1_HUMANPEBP1_HUMANMINT21653829 details
DNMT1_HUMANPHC2_HUMANMINT21653829 details
DNMT1_HUMANMCRI1_HUMANMINT21653829 details
DNMT1_HUMANENSA_HUMANMINT21653829 details
DNMT1_HUMANEF1A1_HUMANMINT21653829 details
DNMT1_HUMANTRIM3_HUMANMINT21653829 details
DNMT1_HUMANNGRN_HUMANMINT21653829 details
DNMT1_HUMANCBX5_HUMANBioGRID12867029 17470536 details
DNMT1_HUMANSUV91_HUMANBioGRID, HPRD12711675 17085482 details
DNMT1_HUMANE2F1_HUMANBioGRID10888886 details
DNMT1_HUMANCXXC1_HUMANBioGRID18680430 details
DNMT1_HUMANSP1_HUMANBioGRID17124180 details
DNMT1_HUMANSP3_HUMANBioGRID17124180 details
DNMT1_HUMANEHMT2_HUMANBioGRID17085482 23708667 details
DNMT1_HUMANSTAT3_HUMANBioGRID15870198 25854163 details
DNMT1_HUMANSMCA5_HUMANBioGRID15313181 details
DNMT1_HUMANP53_HUMANBioGRID17991895 23038753 32807901 details
DNMT1_HUMANCHK1_HUMANBioGRID17991895 20940144 details
DNMT1_HUMANWT1_HUMANBioGRID21378168 details
DNMT1_HUMANSUZ12_HUMANBioGRID21378168 27634302 details
DNMT1_HUMANHSP74_HUMANBioGRID21745816 details
DNMT1_HUMANRUXG_HUMANBioGRID21745816 details
DNMT1_HUMANBIP_HUMANBioGRID21745816 details
DNMT1_HUMANRAD9A_HUMANBioGRID20940144 details
DNMT1_HUMANKAT5_HUMANBioGRID21045206 29268763 details
DNMT1_HUMANDAXX_HUMANBioGRID14978102 23038753 23548901 details
DNMT1_HUMANGA45A_HUMANBioGRID22135303 details
DNMT1_HUMANUHRF2_HUMANBioGRID22064703 27114453 29691401 details
DNMT1_HUMANTIF1B_HUMANBioGRID21670149 22055183 29955894 details
DNMT1_HUMANZFP57_HUMANBioGRID22055183 details
DNMT1_HUMANDNMT1_HUMANBioGRID, HPRD10888886 19173286 details
DNMT1_HUMANSH3K1_HUMANBioGRID19531213 details
DNMT1_HUMANKDM1A_HUMANBioGRID21670149 22278882 31130994 details
DNMT1_HUMANNR2C1_HUMANBioGRID21670149 details
DNMT1_HUMANNR2C2_HUMANBioGRID21670149 30463901 details
DNMT1_HUMANCHD4_HUMANBioGRID21670149 23708667 details
DNMT1_HUMANRBBP4_HUMANBioGRID21670149 details
DNMT1_HUMANMBD3_HUMANBioGRID21670149 details
DNMT1_HUMANDPOD3_HUMANBioGRID21670149 details
DNMT1_HUMANHDAC3_HUMANBioGRID21670149 details
DNMT1_HUMANRELB_HUMANBioGRID23548901 details
DNMT1_HUMANCTBP1_HUMANBioGRID17972916 details
DNMT1_HUMANH2A2C_HUMANBioGRID26065575 details
DNMT1_HUMANMRTFA_HUMANBioGRID25854163 details
DNMT1_HUMANCCNB1_HUMANBioGRID27030811 details
DNMT1_HUMANSNAI1_HUMANBioGRID26794444 28067227 details
DNMT1_HUMANRBBP7_HUMANBioGRID28143904 details
DNMT1_HUMANHIC1_HUMANBioGRID27720955 details
DNMT1_HUMANMYCN_HUMANBioGRID23280764 details
DNMT1_HUMANZBT7A_HUMANBioGRID23658227 details
DNMT1_HUMANBCOR_HUMANBioGRID23658227 details
DNMT1_HUMANRNF4_HUMANBioGRID29634367 details
DNMT1_HUMANCUL4A_HUMANBioGRID29691401 details
DNMT1_HUMANP20L1_HUMANBioGRID29691401 details
DNMT1_HUMANNCOR1_HUMANBioGRID30463901 details
DNMT1_HUMANFKBP4_HUMANBioGRID26602018 details
DNMT1_HUMANCDK5_HUMANBioGRID26602018 details
DNMT1_HUMANCD5R1_HUMANBioGRID26602018 details
DNMT1_HUMANZN263_HUMANBioGRID32051553 details
DNMT1_HUMANRELN_HUMANBioGRID25476119 details
DNMT1_HUMANDCE1_HUMANBioGRID25476119 details
DNMT1_HUMANBDNF_HUMANBioGRID25476119 details
DNMT1_HUMANHMGB1_HUMANHPRD11748221 details
DNMT1_HUMANDYL1_HUMANHPRD14760703 details