Entity Details

Primary name PCSK6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29122
EntryNamePCSK6_HUMAN
FullNameProprotein convertase subtilisin/kexin type 6
TaxID9606
Evidenceevidence at protein level
Length969
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesPCSK6

GO terms

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GOName
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0008201 heparin binding
GO:0009100 glycoprotein metabolic process
GO:0009986 cell surface
GO:0016020 membrane
GO:0016485 protein processing
GO:0016486 peptide hormone processing
GO:0030510 regulation of BMP signaling pathway
GO:0032455 nerve growth factor processing
GO:0032902 nerve growth factor production
GO:0032940 secretion by cell
GO:0048406 nerve growth factor binding
GO:0051004 regulation of lipoprotein lipase activity
GO:0062023 collagen-containing extracellular matrix
GO:0070268 cornification

Subcellular Location

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Subcellular Location
Endomembrane system
Endoplasmic reticulum
Secreted

Domains

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DomainNameCategoryType
IPR000209 Peptidase S8/S53 domainDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR002884 P domainDomainDomain
IPR006212 Furin-like repeatRepeatRepeat
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR010909 PLACDomainDomain
IPR015500 Peptidase S8, subtilisin-relatedFamilyFamily
IPR022398 Peptidase S8, subtilisin, His-active siteSiteActive site
IPR023827 Peptidase S8, subtilisin, Asp-active siteSiteActive site
IPR023828 Peptidase S8, subtilisin, Ser-active siteSiteActive site
IPR032778 Growth factor receptor domain 4DomainDomain
IPR032815 Peptidase S8, pro-domainDomainDomain
IPR034182 Kexin/furin catalytic domainDomainDomain
IPR036852 Peptidase S8/S53 domain superfamilyFamilyHomologous superfamily
IPR038466 Peptidase S8, pro-domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
PCSK6_HUMANCAC1A_HUMANBioGRID, IntAct21078624 details
PCSK6_HUMANZN441_HUMANBioGRID, IntAct32296183 details
PCSK6_HUMANPCSK5_HUMANBioGRID, IntAct32296183 details
PCSK6_HUMANRXRB_HUMANIntAct20195357 details