Entity Details

Primary name PTN6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29350
EntryNamePTN6_HUMAN
FullNameTyrosine-protein phosphatase non-receptor type 6
TaxID9606
Evidenceevidence at protein level
Length595
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesPTPN6

GO terms

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GOName
GO:0001784 phosphotyrosine residue binding
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005911 cell-cell junction
GO:0006470 protein dephosphorylation
GO:0007186 G protein-coupled receptor signaling pathway
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0017124 SH3 domain binding
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0030220 platelet formation
GO:0031295 T cell costimulation
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0033277 abortive mitotic cell cycle
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035556 intracellular signal transduction
GO:0035580 specific granule lumen
GO:0035855 megakaryocyte development
GO:0042105 alpha-beta T cell receptor complex
GO:0042130 negative regulation of T cell proliferation
GO:0042169 SH2 domain binding
GO:0042267 natural killer cell mediated cytotoxicity
GO:0042981 regulation of apoptotic process
GO:0043312 neutrophil degranulation
GO:0043407 negative regulation of MAP kinase activity
GO:0045577 regulation of B cell differentiation
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0050839 cell adhesion molecule binding
GO:0050853 B cell receptor signaling pathway
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:0070062 extracellular exosome
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:0071345 cellular response to cytokine stimulus
GO:0140031 phosphorylation-dependent protein binding
GO:1904724 tertiary granule lumen
GO:1905867 epididymis development
GO:2000045 regulation of G1/S transition of mitotic cell cycle

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000242 PTP type protein phosphataseDomainDomain
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR012152 Protein-tyrosine phosphatase, non-receptor type-6, -11FamilyFamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01133 Tiludronic acidDrugbanksmall molecule

Interactions

141 interactions

InteractorPartnerSourcesPublicationsLink
PTN6_HUMANROS1_HUMANBioGRID, HPRD, MINT11266449 17416557 details
PTN6_HUMANCD22_HUMANBioGRID, HPRD, IntAct10228003 11356834 11551923 15588985 7618087 8627166 9890995 details
PTN6_HUMANM3K4_HUMANMINT15601262 details
PTN6_HUMANTMM62_HUMANHPRD, IntAct16169070 details
PTN6_HUMANEPOR_HUMANBioGRID, HPRD, MINT7228577 7528537 7528577 7889566 details
PTN6_HUMANFCG2B_HUMANBioGRID, HPRD, MINT7716523 8577729 9148918 9603468 details
PTN6_HUMANKI2L3_HUMANHPRD, MINT8574854 8648092 8691154 9148918 details
PTN6_HUMANPILRA_HUMANBioGRID, HPRD, UniProt10660620 10903717 details
PTN6_HUMANLAIR1_HUMANBioGRID, HPRD, MINT, UniProt10660620 10764762 10903717 11160222 15703304 9285412 details
PTN6_HUMANGRB2_HUMANBioGRID, HPRD, MINT, UniProt10660620 10747947 11964172 25535246 8632004 details
PTN6_HUMANSHPS1_HUMANBioGRID, HPRD, UniProt10660565 10660620 14662855 8943344 9632768 details
PTN6_HUMANESR1_HUMANHPRD, MINT7539106 details
PTN6_HUMANCADH2_HUMANIntAct19167335 details
PTN6_HUMANPGFRB_HUMANBioGRID, IntAct19167335 9452499 details
PTN6_HUMANLCK_HUMANBioGRID, HPRD, IntAct, MINT10488096 10574931 10617656 11294838 12468540 19167335 7512963 8114715 8692915 details
PTN6_HUMANVGFR2_HUMANBioGRID, HPRD, MINT, Molecular Connections12887919 16453023 18377662 28065597 28183800 9405464 details
PTN6_HUMANCD33_HUMANBioGRID, HPRD, MINT, UniProt10206955 10556798 17947393 24216507 details
PTN6_HUMANP85A_HUMANBioGRID, HPRD, MINT10488096 11160222 11337495 9452499 details
PTN6_HUMANCLM1_HUMANBioGRID, HPRD, MINT14662855 15184070 15549731 details
PTN6_HUMANIL4RA_HUMANBioGRID, HPRD, MINT11714803 27742835 9392697 details
PTN6_HUMANIL3RB_HUMANBioGRID, HPRD, MINT7528537 8246974 9162089 9254654 details
PTN6_HUMANPECA1_HUMANBioGRID, HPRD, MINT10350061 9774457 details
PTN6_HUMANSIG10_HUMANHPRD, MINT12163025 details
PTN6_HUMANEGFR_HUMANBioGRID, HPRD, MINT22973453 25187647 28065597 7673163 9733788 details
PTN6_HUMANKIT_HUMANBioGRID, HPRD, MINT12614164 7684496 9528781 details
PTN6_HUMANLYN_HUMANBioGRID, HPRD, IntAct10488096 10574931 10871605 11042209 12468540 22624718 8114715 8692915 details
PTN6_HUMANFAK1_HUMANBioGRID, IntAct25814554 details
PTN6_HUMANOLIG1_HUMANBioGRID, IntAct25814554 details
PTN6_HUMANFHL3_HUMANBioGRID, IntAct25416956 details
PTN6_HUMANNFAT5_HUMANDIP20351292 details
PTN6_HUMANIGF1R_HUMANBioGRID, MINT28065597 details
PTN6_HUMANLMTK2_HUMANBioGRID, MINT28065597 details
PTN6_HUMANLMTK1_HUMANBioGRID, MINT28065597 details
PTN6_HUMANERBB2_HUMANBioGRID, MINT22973453 28065597 details
PTN6_HUMANERBB3_HUMANBioGRID, MINT22973453 28065597 details
PTN6_HUMANROR1_HUMANBioGRID, MINT28065597 details
PTN6_HUMANROR2_HUMANBioGRID, MINT28065597 details
PTN6_HUMANPTK7_HUMANBioGRID, MINT28065597 details
PTN6_HUMANERBB4_HUMANBioGRID, MINT22973453 28065597 details
PTN6_HUMANFGFR2_HUMANBioGRID, MINT12887919 28065597 details
PTN6_HUMANFGFR4_HUMANBioGRID, MINT28065597 details
PTN6_HUMANCD72_HUMANBioGRID, HPRD11114375 12882840 15588985 9590210 9740800 details
PTN6_HUMANFAK2_HUMANBioGRID, HPRD10521452 10747947 details
PTN6_HUMANKSYK_HUMANBioGRID, HPRD10072516 10747947 10871605 11356834 details
PTN6_HUMANLCP2_HUMANBioGRID, HPRD15588985 8760799 9765283 details
PTN6_HUMANPHAG1_HUMANBioGRID, HPRD10790433 details
PTN6_HUMANHXA10_HUMANBioGRID, HPRD12145285 details
PTN6_HUMANTYK2_HUMANBioGRID, HPRD7629131 8780698 details
PTN6_HUMANJAK1_HUMANBioGRID, HPRD7629131 9520455 details
PTN6_HUMANVAV_HUMANBioGRID, HPRD8632004 details
PTN6_HUMANZAP70_HUMANBioGRID, HPRD10458769 8638162 details
PTN6_HUMANCTND1_HUMANBioGRID, HPRD10835420 details
PTN6_HUMANKPCD_HUMANBioGRID, HPRD11723252 details
PTN6_HUMANFCRL3_HUMANBioGRID12051764 details
PTN6_HUMANLAT_HUMANBioGRID27221712 details
PTN6_HUMANPLCG2_HUMANBioGRID27221712 details
PTN6_HUMANSRC_HUMANBioGRID, HPRD10871605 12468645 14699166 8647855 9261115 details
PTN6_HUMANCDK1_HUMANBioGRID14699166 details
PTN6_HUMANGRDN_HUMANBioGRID21799016 details
PTN6_HUMANTRAF3_HUMANBioGRID32779804 details
PTN6_HUMANPILRB_HUMANHPRD9632768 details
PTN6_HUMANSIG12_HUMANHPRD11328818 details
PTN6_HUMANTLR10_HUMANHPRD16482509 details
PTN6_HUMANSPAT2_HUMANHPRD11160222 details
PTN6_HUMANKHDR1_HUMANHPRD, IntAct9045636 details
PTN6_HUMANTFG_HUMANHPRD, MINT15557341 details
PTN6_HUMANNTRK1_HUMANBioGRID, MINT15557341 29715200 details
PTN6_HUMANCAV1_HUMANBioGRID, HPRD, MINT12176037 details
PTN6_HUMANBTLA_HUMANHPRD, MINT12796776 14652006 details
PTN6_HUMANPDCD1_HUMANMINT15240681 details
PTN6_HUMANG6B_HUMANBioGRID, HPRD, MINT11544253 details
PTN6_HUMANTNR1A_HUMANHPRD, MINT11786908 details
PTN6_HUMAN3BP2_HUMANMINT16649996 details
PTN6_HUMANKI2L1_HUMANMINT8691146 details
PTN6_HUMANCASP8_HUMANMINT18086677 details
PTN6_HUMANCD37_HUMANIntAct22624718 details
PTN6_HUMANTHMS1_HUMANMINT25535246 details
PTN6_HUMANCD244_HUMANIntAct, UniProt11489943 24642916 details
PTN6_HUMANLIRB1_HUMANBioGRID, IntAct18802077 9842885 details
PTN6_HUMANLIRB3_HUMANIntAct18802077 details
PTN6_HUMANLIRB4_HUMANIntAct18802077 details
PTN6_HUMANLIRB2_HUMANIntAct18802077 details
PTN6_HUMANKCC1A_HUMANDIP25915125 details
PTN6_HUMANINSR_HUMANBioGRID, HPRD, MINT12468540 28065597 7512963 8114715 8692915 details
PTN6_HUMANBCR_HUMANBioGRID, HPRD27432908 9211920 9788431 details
PTN6_HUMANABL1_HUMANBioGRID, HPRD10488096 10574931 12468540 7512963 8114715 8692915 details
PTN6_HUMANCXCR4_HUMANBioGRID, HPRD10506573 details
PTN6_HUMANCBL_HUMANBioGRID, HPRD12176909 details
PTN6_HUMANTRML1_HUMANBioGRID, HPRD12393607 details
PTN6_HUMANJAK2_HUMANBioGRID, HPRD10772872 8943354 details
PTN6_HUMANNOS1_HUMANBioGRID, HPRD11511520 details
PTN6_HUMANGAB2_HUMANBioGRID, HPRD11812650 11895767 details
PTN6_HUMANCD5_HUMANBioGRID, HPRD10082557 details
PTN6_HUMANSSR2_HUMANBioGRID, HPRD11920268 9305905 details
PTN6_HUMANSOS1_HUMANBioGRID, HPRD8632004 details
PTN6_HUMANSIG11_HUMANBioGRID, HPRD11986327 details
PTN6_HUMANBLNK_HUMANBioGRID, HPRD10903736 11356834 15588985 details
PTN6_HUMANIL6RB_HUMANBioGRID, HPRD10800945 details
PTN6_HUMANLIFR_HUMANBioGRID, HPRD10800945 details
PTN6_HUMANSTA5B_HUMANBioGRID, HPRD9211920 details
PTN6_HUMANTHIO_HUMANBioGRID19561639 details
PTN6_HUMANPLCG1_HUMANBioGRID27221712 details
PTN6_HUMANPTN11_HUMANBioGRID, HPRD27432908 8541543 details
PTN6_HUMANPTN6_HUMANBioGRID, HPRD11920268 27432908 31980649 7518460 8574854 9151699 9531263 9842885 9973385 details
PTN6_HUMANSIGL7_HUMANBioGRID15703304 details
PTN6_HUMANSIGL9_HUMANBioGRID15703304 details
PTN6_HUMANFGRL1_HUMANBioGRID23640895 details
PTN6_HUMANITA1_HUMANBioGRID12887919 details
PTN6_HUMANTNR25_HUMANBioGRID28183800 details
PTN6_HUMANRNF6_HUMANBioGRID29288235 30496760 details
PTN6_HUMANPDK1_HUMANBioGRID19591923 details
PTN6_HUMANRNF38_HUMANBioGRID30112836 details
PTN6_HUMANCL12A_HUMANBioGRID15238421 details
PTN6_HUMANTRAF6_HUMANBioGRID, HPRD14500659 31942069 details
PTN6_HUMANINAR1_HUMANHPRD8524272 9029147 details
PTN6_HUMANGHR_HUMANHPRD9632636 details
PTN6_HUMANDOK1_HUMANHPRD10585470 details
PTN6_HUMANIRS4_HUMANHPRD12774026 details
PTN6_HUMANCLC4A_HUMANHPRD11178971 details
PTN6_HUMANCUZD1_HUMANHPRD12361947 15588985 details
PTN6_HUMANKLRB1_HUMANHPRD10229828 details
PTN6_HUMANCEAM1_HUMANHPRD9867848 details
PTN6_HUMANCTNB1_HUMANHPRD12571228 15588985 details
PTN6_HUMANACTN4_HUMANHPRD15070900 15588985 details
PTN6_HUMANFCERB_HUMANHPRD9379041 details
PTN6_HUMANKI2LA_HUMANHPRD15187115 details
PTN6_HUMANMYH9_HUMANHPRD12705885 details
PTN6_HUMANFLT3_HUMANHPRD15831474 details
PTN6_HUMANKPCA_HUMANHPRD15269224 details
PTN6_HUMANACTN1_HUMANHPRD15070900 details
PTN6_HUMANIRS2_HUMANHPRD12198247 details
PTN6_HUMANCD79A_HUMANHPRD7539038 details
PTN6_HUMANTNR6_HUMANHPRD11786908 details
PTN6_HUMANIL2RB_HUMANHPRD9520455 details
PTN6_HUMANCD79B_HUMANHPRD7539038 details
PTN6_HUMANCD3Z_HUMANHPRD14672952 details
PTN6_HUMANJAK3_HUMANHPRD9520455 details
PTN6_HUMANSHC1_HUMANHPRD8541543 details
PTN6_HUMANSTAT6_HUMANHPRD12791978 details
PTN6_HUMANPTPRC_HUMANHPRD10228003 9368621 details
PTN6_HUMANNKG2A_HUMANHPRD9485206 details