Entity Details

Primary name ARRB2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP32121
EntryNameARRB2_HUMAN
FullNameBeta-arrestin-2
TaxID9606
Evidenceevidence at protein level
Length409
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesARRB2

GO terms

Show/Hide Table
GOName
GO:0001664 G protein-coupled receptor binding
GO:0001933 negative regulation of protein phosphorylation
GO:0002031 G protein-coupled receptor internalization
GO:0002032 desensitization of G protein-coupled receptor signaling pathway by arrestin
GO:0002092 positive regulation of receptor internalization
GO:0005102 signaling receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0006366 transcription by RNA polymerase II
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007212 dopamine receptor signaling pathway
GO:0007420 brain development
GO:0007628 adult walking behavior
GO:0010628 positive regulation of gene expression
GO:0014069 postsynaptic density
GO:0015031 protein transport
GO:0016323 basolateral plasma membrane
GO:0016567 protein ubiquitination
GO:0016579 protein deubiquitination
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0030139 endocytic vesicle
GO:0030168 platelet activation
GO:0031397 negative regulation of protein ubiquitination
GO:0031410 cytoplasmic vesicle
GO:0031623 receptor internalization
GO:0031625 ubiquitin protein ligase binding
GO:0031691 alpha-1A adrenergic receptor binding
GO:0031692 alpha-1B adrenergic receptor binding
GO:0031701 angiotensin receptor binding
GO:0031702 type 1 angiotensin receptor binding
GO:0031748 D1 dopamine receptor binding
GO:0031762 follicle-stimulating hormone receptor binding
GO:0031826 type 2A serotonin receptor binding
GO:0031859 platelet activating factor receptor binding
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032226 positive regulation of synaptic transmission, dopaminergic
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032695 negative regulation of interleukin-12 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0034260 negative regulation of GTPase activity
GO:0034392 negative regulation of smooth muscle cell apoptotic process
GO:0042699 follicle-stimulating hormone signaling pathway
GO:0042802 identical protein binding
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043197 dendritic spine
GO:0043422 protein kinase B binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0044877 protein-containing complex binding
GO:0045211 postsynaptic membrane
GO:0045953 negative regulation of natural killer cell mediated cytotoxicity
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0051019 mitogen-activated protein kinase binding
GO:0051897 positive regulation of protein kinase B signaling
GO:0051898 negative regulation of protein kinase B signaling
GO:0051928 positive regulation of calcium ion transport
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060079 excitatory postsynaptic potential
GO:0060326 cell chemotaxis
GO:0061024 membrane organization
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071889 14-3-3 protein binding
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:1904037 positive regulation of epithelial cell apoptotic process
GO:1990763 arrestin family protein binding
GO:2000573 positive regulation of DNA biosynthetic process
GO:2000727 positive regulation of cardiac muscle cell differentiation

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Membrane
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000698 ArrestinFamilyFamily
IPR011021 Arrestin-like, N-terminalDomainDomain
IPR011022 Arrestin C-terminal-like domainDomainDomain
IPR014752 Arrestin-like, C-terminalFamilyHomologous superfamily
IPR014753 Arrestin, N-terminalFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR017864 Arrestin, conserved siteSiteConserved site

Diseases

Show/Hide Table

Interactions

120 interactions

InteractorPartnerSourcesPublicationsLink
ARRB2_HUMANMDM2_HUMANBioGRID, HPRD, IntAct, MINT11588219 12488444 12538596 15878855 17984062 18544533 21081496 21389118 21466165 21988832 26545496 32450252 32828283 details
ARRB2_HUMANHIPK3_HUMANBioGRID, HPRD, MINT15231748 details
ARRB2_HUMANMED8_HUMANBioGRID, HPRD, IntAct16169070 details
ARRB2_HUMANSTC2_HUMANBioGRID, HPRD, IntAct16169070 details
ARRB2_HUMANSMRC2_HUMANBioGRID, HPRD, IntAct16169070 details
ARRB2_HUMANNDUS7_HUMANHPRD, IntAct16169070 details
ARRB2_HUMANCSK21_HUMANBioGRID, HPRD, IntAct11877451 17620599 details
ARRB2_HUMANAP2B1_HUMANBioGRID, IntAct10097102 12070169 17620599 21118812 details
ARRB2_HUMANFLNA_HUMANBioGRID, HPRD, IntAct16611986 17620599 17984062 details
ARRB2_HUMANPDE4D_HUMANBioGRID, DIP, IntAct, MINT14500724 17620599 19955404 20664520 details
ARRB2_HUMANMK09_HUMANBioGRID, IntAct19060904 25416956 31515488 32296183 details
ARRB2_HUMANMK10_HUMANBioGRID, HPRD, MINT11090355 11356842 19782076 details
ARRB2_HUMANM3K5_HUMANBioGRID, HPRD, MINT11090355 11356842 19306926 19782076 details
ARRB2_HUMANMP2K4_HUMANBioGRID, MINT11090355 19782076 details
ARRB2_HUMANCDC42_HUMANBioGRID, IntAct20936779 details
ARRB2_HUMANADRB2_HUMANBioGRID, DIP, HPRD, IntAct, MINT17148612 17666399 23208550 24561123 24658140 27226565 details
ARRB2_HUMANKIF3A_HUMANMINT23877428 details
ARRB2_HUMANILK_HUMANMINT23877428 details
ARRB2_HUMANSMO_HUMANMINT23877428 details
ARRB2_HUMANEGFR_HUMANBioGRID, IntAct24658140 25402006 31980649 details
ARRB2_HUMANDRD2_HUMANBioGRID, IntAct21256133 25162404 32450252 details
ARRB2_HUMANAKT1_HUMANBioGRID, DIP18191226 19122674 19262695 details
ARRB2_HUMANINSR_HUMANBioGRID, DIP19122674 details
ARRB2_HUMAN5HT2A_HUMANDIP26158621 details
ARRB2_HUMANAGTR1_HUMANBioGRID, HPRD, MINT11226259 11279203 15611106 28298427 details
ARRB2_HUMANAPJ_HUMANIntAct30409826 details
ARRB2_HUMANGNDS_HUMANBioGRID, HPRD12105416 details
ARRB2_HUMANCYH2_HUMANBioGRID, HPRD11533043 details
ARRB2_HUMANOPRD_HUMANBioGRID, HPRD11259507 details
ARRB2_HUMANLSHR_HUMANBioGRID11867621 details
ARRB2_HUMANITCH_HUMANBioGRID17947233 18544533 details
ARRB2_HUMANUBP33_HUMANBioGRID19363159 19424180 24377933 27835898 details
ARRB2_HUMANPRKN_HUMANBioGRID21466165 details
ARRB2_HUMANUBC_HUMANBioGRID17620599 21378163 details
ARRB2_HUMANOX1R_HUMANBioGRID21378163 details
ARRB2_HUMANSL9A5_HUMANBioGRID, HPRD15699339 details
ARRB2_HUMANIKBA_HUMANBioGRID, HPRD15125834 15173580 details
ARRB2_HUMANCLH1_HUMANBioGRID, HPRD10097102 17666399 9169477 details
ARRB2_HUMANLIMK1_HUMANBioGRID17500066 details
ARRB2_HUMANPTGDS_HUMANBioGRID21112970 details
ARRB2_HUMANOPSD_HUMANBioGRID9852134 details
ARRB2_HUMANAP1B1_HUMANBioGRID, HPRD10097102 11877451 12070169 details
ARRB2_HUMANCSK22_HUMANBioGRID, HPRD11877451 details
ARRB2_HUMANOXER1_HUMANBioGRID24733850 details
ARRB2_HUMANARBK1_HUMANBioGRID29054428 details
ARRB2_HUMANDLG4_HUMANBioGRID26898829 details
ARRB2_HUMANCRFR1_HUMANBioGRID16412099 details
ARRB2_HUMANNOLC1_HUMANBioGRID, IntAct17353931 17620599 26399832 28514442 29999490 details
ARRB2_HUMANTCOF_HUMANBioGRID, IntAct17353931 17620599 26399832 29999490 details
ARRB2_HUMANPPM1A_HUMANBioGRID, IntAct17620599 details
ARRB2_HUMANCALM2_HUMANBioGRID, IntAct17620599 details
ARRB2_HUMANNUCL_HUMANBioGRID, IntAct17620599 details
ARRB2_HUMANPPM1B_HUMANBioGRID, IntAct17620599 25241761 details
ARRB2_HUMANMK01_HUMANBioGRID, HPRD, IntAct11226259 15699045 17620599 25241761 details
ARRB2_HUMANTAB1_HUMANBioGRID, IntAct17620599 25241761 details
ARRB2_HUMANSTK38_HUMANBioGRID, IntAct17620599 details
ARRB2_HUMANKPYM_HUMANBioGRID, IntAct17620599 details
ARRB2_HUMANHSP7C_HUMANBioGRID, IntAct17620599 details
ARRB2_HUMAN1433T_HUMANBioGRID, IntAct17620599 details
ARRB2_HUMANGELS_HUMANBioGRID, IntAct17620599 details
ARRB2_HUMANCOF1_HUMANBioGRID, IntAct, UniProt17500066 17620599 details
ARRB2_HUMANZRAB2_HUMANBioGRID, IntAct17620599 details
ARRB2_HUMANAP3B2_HUMANBioGRID, IntAct11877451 17620599 details
ARRB2_HUMANIMB1_HUMANBioGRID, IntAct17620599 32450252 details
ARRB2_HUMANS10A9_HUMANBioGRID, IntAct17620599 details
ARRB2_HUMANEGLN_HUMANMINT22940691 details
ARRB2_HUMANMK03_HUMANBioGRID, IntAct12473660 25241761 details
ARRB2_HUMANNEDD4_HUMANBioGRID, MINT18544533 23208550 details
ARRB2_HUMANHGS_HUMANBioGRID, MINT20505072 23208550 details
ARRB2_HUMANPE2R2_HUMANBioGRID, IntAct11418617 24069330 details
ARRB2_HUMANNPHN_HUMANDIP16968782 details
ARRB2_HUMANAKT2_HUMANDIP19122674 details
ARRB2_HUMANSRC_HUMANBioGRID, DIP11877451 19122674 19202075 23242524 details
ARRB2_HUMANEDNRA_HUMANBioGRID, DIP19202075 details
ARRB2_HUMANTRAF6_HUMANBioGRID, DIP16378096 19955404 25425640 details
ARRB2_HUMANARF6_HUMANBioGRID, HPRD11533043 11867621 details
ARRB2_HUMANV2R_HUMANBioGRID, HPRD12473660 details
ARRB2_HUMANPTAFR_HUMANBioGRID, HPRD11729201 9037196 details
ARRB2_HUMANDRD4_HUMANBioGRID20100572 27155323 details
ARRB2_HUMANAGRG1_HUMANBioGRID21708946 details
ARRB2_HUMANIGF1R_HUMANBioGRID15878855 19165858 23188799 details
ARRB2_HUMANCHIP_HUMANBioGRID19306926 details
ARRB2_HUMANMP2K1_HUMANBioGRID11226259 details
ARRB2_HUMANPTPA_HUMANBioGRID21502318 details
ARRB2_HUMANTEBP_HUMANBioGRID21502318 details
ARRB2_HUMANCALM1_HUMANBioGRID17620599 details
ARRB2_HUMANCALM3_HUMANBioGRID17620599 details
ARRB2_HUMANPRP4_HUMANBioGRID17620599 details
ARRB2_HUMANAP2M1_HUMANBioGRID, HPRD17666399 17984062 details
ARRB2_HUMANC5AR1_HUMANBioGRID, HPRD12464600 details
ARRB2_HUMANARRD3_HUMANBioGRID23208550 23236378 details
ARRB2_HUMANARRD4_HUMANBioGRID23236378 details
ARRB2_HUMANSIR1_HUMANBioGRID23382074 details
ARRB2_HUMANGLUC_HUMANBioGRID18445652 details
ARRB2_HUMANCSK_HUMANBioGRID19262695 details
ARRB2_HUMANAGRB1_HUMANBioGRID23782696 details
ARRB2_HUMANCYH1_HUMANBioGRID17846866 details
ARRB2_HUMANTA2R_HUMANBioGRID16956790 details
ARRB2_HUMANSENP1_HUMANBioGRID25425640 details
ARRB2_HUMANRAF1_HUMANBioGRID, HPRD11226259 details
ARRB2_HUMANKPCB_HUMANBioGRID26545496 29054428 details
ARRB2_HUMANKLH12_HUMANBioGRID27155323 details
ARRB2_HUMANCUL3_HUMANBioGRID27155323 details
ARRB2_HUMANKBTB8_HUMANBioGRID26399832 details
ARRB2_HUMANPE2R4_HUMANBioGRID11418617 details
ARRB2_HUMANMSHR_HUMANBioGRID28947386 details
ARRB2_HUMANMGRN1_HUMANBioGRID28947386 details
ARRB2_HUMANUBP20_HUMANBioGRID30354204 details
ARRB2_HUMANGRM1_HUMANBioGRID11723231 details
ARRB2_HUMANGBB1_HUMANBioGRID32505358 details
ARRB2_HUMANTULP3_HUMANBioGRID33187986 details
ARRB2_HUMANNTR1_HUMANHPRD11279203 details
ARRB2_HUMANOXYR_HUMANHPRD11279203 details
ARRB2_HUMANNEUT_HUMANHPRD12473660 details
ARRB2_HUMANTRH_HUMANHPRD12473660 details
ARRB2_HUMANTGBR3_HUMANHPRD12958365 details
ARRB2_HUMANCXCR4_HUMANHPRD10644702 details
ARRB2_HUMANDVL2_HUMANHPRD12958364 details
ARRB2_HUMANFZD4_HUMANHPRD12958364 details
ARRB2_HUMAN5HT2C_HUMANHPRD18768750 details