Entity Details

Primary name MERL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35240
EntryNameMERL_HUMAN
FullNameMerlin
TaxID9606
Evidenceevidence at protein level
Length595
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesNF2

GO terms

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GOName
GO:0001707 mesoderm formation
GO:0001953 negative regulation of cell-matrix adhesion
GO:0003779 actin binding
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0006469 negative regulation of protein kinase activity
GO:0007398 ectoderm development
GO:0008285 negative regulation of cell population proliferation
GO:0014010 Schwann cell proliferation
GO:0014013 regulation of gliogenesis
GO:0016020 membrane
GO:0021766 hippocampus development
GO:0022408 negative regulation of cell-cell adhesion
GO:0030027 lamellipodium
GO:0030036 actin cytoskeleton organization
GO:0030336 negative regulation of cell migration
GO:0030864 cortical actin cytoskeleton
GO:0031527 filopodium membrane
GO:0031647 regulation of protein stability
GO:0032154 cleavage furrow
GO:0032587 ruffle membrane
GO:0035330 regulation of hippo signaling
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
GO:0042981 regulation of apoptotic process
GO:0043005 neuron projection
GO:0043409 negative regulation of MAPK cascade
GO:0044297 cell body
GO:0045177 apical part of cell
GO:0045216 cell-cell junction organization
GO:0045597 positive regulation of cell differentiation
GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT
GO:0048471 perinuclear region of cytoplasm
GO:0051496 positive regulation of stress fiber assembly
GO:0051726 regulation of cell cycle
GO:0070306 lens fiber cell differentiation
GO:0072091 regulation of stem cell proliferation
GO:1900180 regulation of protein localization to nucleus
GO:2000177 regulation of neural precursor cell proliferation

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Cytoplasmic granule
Nucleus

Domains

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DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR000798 Ezrin/radixin/moesin-likeFamilyFamily
IPR008954 Moesin tail domain superfamilyFamilyHomologous superfamily
IPR011174 Ezrin/radixin/moesinFamilyFamily
IPR011259 Ezrin/radixin/moesin, C-terminalDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR014352 FERM/acyl-CoA-binding protein superfamilyFamilyHomologous superfamily
IPR018979 FERM, N-terminalDomainDomain
IPR018980 FERM, C-terminal PH-like domainDomainDomain
IPR019747 FERM conserved siteSiteConserved site
IPR019748 FERM central domainDomainDomain
IPR019749 Band 4.1 domainDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR041789 ERM family, FERM domain C-lobeDomainDomain

Diseases

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Interactions

137 interactions

InteractorPartnerSourcesPublicationsLink
MERL_HUMANMED28_HUMANBioGRID, IntAct15467741 details
MERL_HUMANNHRF1_HUMANBioGRID, HPRD, IntAct15467741 26045165 9430655 details
MERL_HUMANGTPB4_HUMANIntAct17210637 details
MERL_HUMANSCHI1_HUMANBioGRID, HPRD, UniProt10669747 details
MERL_HUMANIQIP1_HUMANBioGRID, UniProt10669747 details
MERL_HUMANAMOT_HUMANBioGRID, IntAct, MINT19615732 21481793 23414517 24366813 24981860 26045165 26549023 32296183 33058421 34079125 details
MERL_HUMANAMOL2_HUMANBioGRID, IntAct21481793 24255178 26549023 32296183 33058421 details
MERL_HUMANM3K11_HUMANI2D20890305 details
MERL_HUMANMYPC2_HUMANBioGRID, IntAct23414517 details
MERL_HUMANKDM1A_HUMANBioGRID, IntAct, MINT23455924 32814053 34079125 details
MERL_HUMANLATS1_HUMANBioGRID, IntAct24012335 26045165 33058421 34079125 details
MERL_HUMANMERL_HUMANBioGRID, HPRD, IntAct11779178 11856822 15467741 24012335 28205554 28514442 9537418 details
MERL_HUMANBYST_HUMANBioGRID, IntAct32296183 details
MERL_HUMANTXLNB_HUMANBioGRID, IntAct32296183 details
MERL_HUMANEMD_HUMANBioGRID, IntAct26549023 32296183 details
MERL_HUMANDCAF1_HUMANBioGRID, HPRD, IntAct18332868 20178741 21750658 24912773 26549023 28514442 33058421 details
MERL_HUMANBKRB1_HUMANBioGRID, MINT28298427 details
MERL_HUMANHGS_HUMANBioGRID, HPRD, IntAct10861283 11285248 11779178 12444101 12444102 29997244 31467278 32814053 details
MERL_HUMANEIF3C_HUMANIntAct11779178 details
MERL_HUMANSPTB2_HUMANBioGRID, HPRD, IntAct11535133 11779178 9537418 details
MERL_HUMANSEM1_HUMANIntAct32814053 details
MERL_HUMANZKSC8_HUMANIntAct32814053 details
MERL_HUMANZNF20_HUMANIntAct32814053 details
MERL_HUMANVHL_HUMANIntAct32814053 details
MERL_HUMANTSNAX_HUMANIntAct32814053 details
MERL_HUMANTERF1_HUMANIntAct32814053 details
MERL_HUMANNVL_HUMANIntAct32814053 details
MERL_HUMANEED_HUMANIntAct32814053 details
MERL_HUMANEIF3F_HUMANIntAct32814053 details
MERL_HUMANPIAS1_HUMANIntAct32814053 details
MERL_HUMANCSN3_HUMANIntAct32814053 details
MERL_HUMANKT33B_HUMANIntAct32814053 details
MERL_HUMANKC1D_HUMANIntAct32814053 details
MERL_HUMANCBLB_HUMANIntAct32814053 details
MERL_HUMANBEX5_HUMANIntAct32814053 details
MERL_HUMANVSX2_HUMANIntAct32814053 details
MERL_HUMANCL074_HUMANIntAct32814053 details
MERL_HUMANRUFY4_HUMANIntAct32814053 details
MERL_HUMANFAM9A_HUMANIntAct32814053 details
MERL_HUMANZN497_HUMANIntAct32814053 details
MERL_HUMANTRI69_HUMANIntAct32814053 details
MERL_HUMANASB9_HUMANIntAct32814053 details
MERL_HUMANRN183_HUMANIntAct32814053 details
MERL_HUMANVP37A_HUMANIntAct32814053 details
MERL_HUMANZN572_HUMANIntAct32814053 details
MERL_HUMANPIHD2_HUMANIntAct32814053 details
MERL_HUMANMPND_HUMANIntAct32814053 details
MERL_HUMANLNX1_HUMANIntAct32814053 details
MERL_HUMANSPT22_HUMANIntAct32814053 details
MERL_HUMANABLM2_HUMANIntAct32814053 details
MERL_HUMANZN436_HUMANIntAct32814053 details
MERL_HUMANTNIP3_HUMANIntAct32814053 details
MERL_HUMANTUT7_HUMANIntAct32814053 details
MERL_HUMANOTU7B_HUMANIntAct32814053 details
MERL_HUMANOTUB1_HUMANIntAct32814053 details
MERL_HUMANRN138_HUMANIntAct32814053 details
MERL_HUMANATLA1_HUMANIntAct32814053 details
MERL_HUMANDCAF8_HUMANIntAct32814053 details
MERL_HUMANSCAPE_HUMANIntAct32814053 details
MERL_HUMANNSMF_HUMANIntAct32814053 details
MERL_HUMANRYBP_HUMANIntAct32814053 details
MERL_HUMANSNW1_HUMANIntAct32814053 details
MERL_HUMANEMIL1_HUMANIntAct32814053 details
MERL_HUMANNEBL_HUMANIntAct32814053 details
MERL_HUMANCHIP_HUMANIntAct32814053 details
MERL_HUMANSGSM3_HUMANBioGRID, HPRD15541357 details
MERL_HUMANEZRI_HUMANBioGRID, HPRD10036239 17891137 details
MERL_HUMANPAXI_HUMANBioGRID, HPRD12118253 details
MERL_HUMANSDCB1_HUMANBioGRID, HPRD11432873 details
MERL_HUMANAKT1_HUMANBioGRID17891137 21750658 28205554 details
MERL_HUMANAGAP2_HUMANBioGRID17891137 details
MERL_HUMANCD44_HUMANBioGRID, HPRD12356905 17891137 19351837 24912773 28205554 details
MERL_HUMANPYGO2_HUMANBioGRID20937768 details
MERL_HUMANCIP1_HUMANBioGRID16532029 details
MERL_HUMANLATS2_HUMANBioGRID24012335 26045165 28205554 29183995 details
MERL_HUMANKPCA_HUMANBioGRID21750658 details
MERL_HUMANNOP53_HUMANBioGRID21167305 details
MERL_HUMANEGFR_HUMANBioGRID25043298 28205554 details
MERL_HUMANBECN1_HUMANBioGRID28205554 details
MERL_HUMANCBLC_HUMANBioGRID28205554 details
MERL_HUMANGLIS2_HUMANBioGRID28205554 details
MERL_HUMANERD22_HUMANBioGRID28205554 details
MERL_HUMANMP2K5_HUMANBioGRID28205554 details
MERL_HUMANARNT_HUMANBioGRID28205554 details
MERL_HUMANAURKA_HUMANBioGRID28205554 details
MERL_HUMANCCND2_HUMANBioGRID28205554 details
MERL_HUMANCCNE1_HUMANBioGRID28205554 details
MERL_HUMANCDK4_HUMANBioGRID28205554 details
MERL_HUMANCDK6_HUMANBioGRID28205554 details
MERL_HUMANCDN2B_HUMANBioGRID28205554 details
MERL_HUMANCDN2C_HUMANBioGRID28205554 details
MERL_HUMANEPHA2_HUMANBioGRID28205554 details
MERL_HUMANFGFR4_HUMANBioGRID28205554 details
MERL_HUMANMP2K3_HUMANBioGRID28205554 details
MERL_HUMANMYC_HUMANBioGRID28205554 details
MERL_HUMANSTK11_HUMANBioGRID28205554 details
MERL_HUMANTERT_HUMANBioGRID28205554 details
MERL_HUMANTSC1_HUMANBioGRID, HPRD12226091 28205554 details
MERL_HUMANPGFRA_HUMANBioGRID28205554 details
MERL_HUMANRAF1_HUMANBioGRID28205554 details
MERL_HUMANRASF1_HUMANBioGRID28205554 details
MERL_HUMANP53_HUMANBioGRID28205554 details
MERL_HUMANTTYH2_HUMANBioGRID28205554 details
MERL_HUMANARAF_HUMANBioGRID28205554 details
MERL_HUMANDACH1_HUMANBioGRID28205554 details
MERL_HUMANFZR1_HUMANBioGRID28205554 details
MERL_HUMANGRM1_HUMANBioGRID28205554 details
MERL_HUMANHGF_HUMANBioGRID28205554 details
MERL_HUMANMK14_HUMANBioGRID28205554 details
MERL_HUMANERBB2_HUMANBioGRID, HPRD12118253 28205554 details
MERL_HUMANHIF1A_HUMANBioGRID28205554 details
MERL_HUMANIGF1R_HUMANBioGRID28205554 details
MERL_HUMANKAT2A_HUMANBioGRID28205554 details
MERL_HUMANM3K5_HUMANBioGRID28205554 details
MERL_HUMANMDM4_HUMANBioGRID28205554 details
MERL_HUMANMET_HUMANBioGRID28205554 details
MERL_HUMANSOX3_HUMANBioGRID28205554 details
MERL_HUMANSOX4_HUMANBioGRID28205554 details
MERL_HUMANEIF3B_HUMANBioGRID32296183 details
MERL_HUMANGNDS_HUMANHPRD16007223 details
MERL_HUMANINADL_HUMANIntAct21481793 28514442 details
MERL_HUMANPAK1_HUMANHPRD, IntAct11719502 14580336 21481793 details
MERL_HUMANAMOL1_HUMANBioGRID, IntAct, MINT21481793 24366813 24981860 26549023 28514442 33058421 details
MERL_HUMANSOS1_HUMANBioGRID10675333 details
MERL_HUMANDDB1_HUMANBioGRID18332868 20178741 26549023 33058421 details
MERL_HUMANCUL4A_HUMANBioGRID18332868 20178741 details
MERL_HUMANRIT1_HUMANBioGRID18332868 details
MERL_HUMANKIBRA_HUMANBioGRID21233212 details
MERL_HUMANCSN1_HUMANBioGRID22414063 details
MERL_HUMANKSR1_HUMANBioGRID26549023 details
MERL_HUMANFAK1_HUMANBioGRID27736841 details
MERL_HUMANNED4L_HUMANBioGRID33058421 details
MERL_HUMANCUL4B_HUMANBioGRID33058421 details
MERL_HUMANHUWE1_HUMANBioGRID33058421 details
MERL_HUMANXPO1_HUMANHPRD12217955 details
MERL_HUMANCTNB1_HUMANHPRD12695331 details
MERL_HUMANTRBP2_HUMANHPRD15123692 details