Entity Details

Primary name PE2R4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35408
EntryNamePE2R4_HUMAN
FullNameProstaglandin E2 receptor EP4 subtype
TaxID9606
Evidenceevidence at protein level
Length488
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesPTGER4

GO terms

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GOName
GO:0001818 negative regulation of cytokine production
GO:0001819 positive regulation of cytokine production
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004957 prostaglandin E receptor activity
GO:0005886 plasma membrane
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007254 JNK cascade
GO:0009612 response to mechanical stimulus
GO:0016021 integral component of membrane
GO:0030278 regulation of ossification
GO:0032496 response to lipopolysaccharide
GO:0033624 negative regulation of integrin activation
GO:0042093 T-helper cell differentiation
GO:0050728 negative regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0051492 regulation of stress fiber assembly
GO:0060348 bone development
GO:0070371 ERK1 and ERK2 cascade
GO:0071260 cellular response to mechanical stimulus
GO:0071380 cellular response to prostaglandin E stimulus
GO:2000420 negative regulation of eosinophil extravasation

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR001244 Prostaglandin DP receptorFamilyFamily
IPR001758 Prostanoid EP4 receptorFamilyFamily
IPR008365 Prostanoid receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00917 DinoprostoneDrugbanksmall molecule
DB00929 MisoprostolDrugbanksmall molecule
DB09211 LimaprostDrugbanksmall molecule
DB11113 Castor oilDrugbankbiotech
DB12836 GrapiprantDrugbanksmall molecule

Interactions

45 interactions

InteractorPartnerSourcesPublicationsLink
PE2R4_HUMANACTN4_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANCRADD_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANHOP_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANCF298_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANPRS4_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANPRDX1_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANNU153_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANRTF2_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANRN220_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANCTND2_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANBIN1_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANSEC20_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANATX10_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANACY3_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANAPC7_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANWDR19_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANF10A1_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANSLBP_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANSND1_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANS39A8_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANCDPF1_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANPPR3F_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANCRY2_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANEHMT2_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANDPF1_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANCXG2_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANDYST_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANHMOX2_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANKLC1_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANNISCH_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANHMOX1_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANNUBP2_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANPDLI1_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANMPPB_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANPTPRA_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANOSTP_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANSGT1_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANTRAP1_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANT161A_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANVTM2A_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANZN337_HUMANBioGRID, MINT28298427 details
PE2R4_HUMANFEM1A_HUMANBioGRID16424369 details
PE2R4_HUMANSRC_HUMANBioGRID, DIP16432186 23242524 details
PE2R4_HUMANPSN1_HUMANBioGRID19407341 details
PE2R4_HUMANARRB2_HUMANBioGRID11418617 details