Entity Details

Primary name FBN2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35556
EntryNameFBN2_HUMAN
FullNameFibrillin-2
TaxID9606
Evidenceevidence at protein level
Length2912
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesFBN2

GO terms

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GOName
GO:0001527 microfibril
GO:0005201 extracellular matrix structural constituent
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0009653 anatomical structure morphogenesis
GO:0030023 extracellular matrix constituent conferring elasticity
GO:0030198 extracellular matrix organization
GO:0030326 embryonic limb morphogenesis
GO:0030501 positive regulation of bone mineralization
GO:0031012 extracellular matrix
GO:0035583 sequestering of TGFbeta in extracellular matrix
GO:0043010 camera-type eye development
GO:0045669 positive regulation of osteoblast differentiation
GO:0048048 embryonic eye morphogenesis
GO:0060346 bone trabecula formation
GO:0062023 collagen-containing extracellular matrix

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011398 FibrillinFamilyFamily
IPR013032 EGF-like, conserved siteSiteConserved site
IPR017878 TB domainDomainDomain
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR026823 Complement Clr-like EGF domainDomainDomain
IPR036773 TGF-beta binding (TB) domain superfamilyFamilyHomologous superfamily
IPR040872 Fibrillin 1, unique N-terminal domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB11093 Calcium citrateDrugbanksmall molecule
DB11348 Calcium PhosphateDrugbanksmall molecule
DB14481 Calcium phosphate dihydrateDrugbanksmall molecule