Entity Details

Primary name IRS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35568
EntryNameIRS1_HUMAN
FullNameInsulin receptor substrate 1
TaxID9606
Evidenceevidence at protein level
Length1242
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesIRS1

GO terms

Show/Hide Table
GOName
GO:0000165 MAPK cascade
GO:0001784 phosphotyrosine residue binding
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005080 protein kinase C binding
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005899 insulin receptor complex
GO:0005901 caveola
GO:0007165 signal transduction
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0010907 positive regulation of glucose metabolic process
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0030159 signaling receptor complex adaptor activity
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0038111 interleukin-7-mediated signaling pathway
GO:0042169 SH2 domain binding
GO:0042593 glucose homeostasis
GO:0043231 intracellular membrane-bounded organelle
GO:0043434 response to peptide hormone
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0046326 positive regulation of glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046676 negative regulation of insulin secretion
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0071398 cellular response to fatty acid

Subcellular Location

Show/Hide Table

Domains

Show/Hide Table
DomainNameCategoryType
IPR001849 Pleckstrin homology domainDomainDomain
IPR002404 IRS-type PTB domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR039011 Insulin receptor substrateFamilyFamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB08513 [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACIDDrugbanksmall molecule

Interactions

112 interactions

InteractorPartnerSourcesPublicationsLink
IRS1_HUMAN1433E_HUMANBioGRID, HPRD, MINT30240640 9111084 9312143 details
IRS1_HUMANINSR_HUMANBioGRID, DIP, HPRD, IntAct, MINT10455177 11606564 11781100 15629149 16582879 17167487 25667086 7499194 7935368 8626379 8662806 details
IRS1_HUMANPK3CA_HUMANBioGRID, IntAct, MINT12933652 14511371 16150444 16354680 23604317 23643389 27684187 details
IRS1_HUMANP85A_HUMANBioGRID, HPRD, IntAct, MINT11403293 11416002 12107746 12173038 12220227 12730242 1334490 1381348 14511371 14632132 15514089 16043515 16150444 16230374 16354680 16880210 17640984 19561084 22974441 23439647 23643389 25273559 25814554 26839216 29526746 30240640 7659087 7680095 7680644 7935461 8175658 8382612 8388384 8628286 9564850 details
IRS1_HUMANERBB2_HUMANBioGRID, MINT16273093 details
IRS1_HUMANEGFR_HUMANBioGRID, MINT16273093 details
IRS1_HUMANDDR1_HUMANIntAct17721511 details
IRS1_HUMANPTN1_HUMANBioGRID, HPRD, MINT10660596 11579209 details
IRS1_HUMANIGF1R_HUMANBioGRID, HPRD, IntAct10082579 12220227 15629149 7541045 7559507 8530377 8662806 8776723 8895367 details
IRS1_HUMANPTN11_HUMANBioGRID, HPRD, MINT11781100 22974441 7513703 7935386 8505282 9535915 9756938 details
IRS1_HUMANGRB2_HUMANBioGRID, HPRD, IntAct12173038 21706016 22974441 7488107 7629070 8388384 8491186 8536716 8810325 details
IRS1_HUMANNUMB_HUMANBioGRID, IntAct25814554 details
IRS1_HUMANP55G_HUMANBioGRID, HPRD, IntAct10417350 25814554 7542745 9415396 details
IRS1_HUMANBCAR3_HUMANBioGRID, IntAct25814554 details
IRS1_HUMANPELI1_HUMANBioGRID, IntAct25814554 details
IRS1_HUMANLRRK2_HUMANIntAct24947832 details
IRS1_HUMAN1433B_HUMANBioGRID, HPRD, IntAct28514442 30240640 9422753 details
IRS1_HUMANPTPRD_HUMANBioGRID, MINT22305495 details
IRS1_HUMANIL4RA_HUMANHPRD, IntAct8599766 details
IRS1_HUMANFAK1_HUMANBioGRID9822703 details
IRS1_HUMANMK08_HUMANBioGRID, HPRD10722755 11606564 12351658 12417588 details
IRS1_HUMANJAK1_HUMANBioGRID, HPRD11162588 7499365 9492017 details
IRS1_HUMANJAK2_HUMANBioGRID, HPRD11208867 12960006 15316008 9492017 details
IRS1_HUMANKHDR1_HUMANBioGRID11604231 22005517 8175658 details
IRS1_HUMANGRB10_HUMANBioGRID12783867 8621530 details
IRS1_HUMANMTOR_HUMANBioGRID, HPRD11287630 16354680 30240640 details
IRS1_HUMANAP3S1_HUMANBioGRID, HPRD9792713 details
IRS1_HUMANKPCD_HUMANBioGRID, HPRD12031982 15364919 15516986 details
IRS1_HUMANNCK2_HUMANBioGRID9843575 details
IRS1_HUMANAKT1_HUMANBioGRID, HPRD10497255 17640984 details
IRS1_HUMANHDAC2_HUMANBioGRID15522123 details
IRS1_HUMANNEDD4_HUMANBioGRID19953087 details
IRS1_HUMANRPTOR_HUMANBioGRID, HPRD16354680 19561084 30240640 details
IRS1_HUMANFBXW8_HUMANBioGRID18498745 23045529 33854235 details
IRS1_HUMANUBC_HUMANBioGRID23045529 details
IRS1_HUMANKS6B1_HUMANBioGRID18498745 23045529 details
IRS1_HUMANA4_HUMANBioGRID21832049 details
IRS1_HUMANPLCG2_HUMANBioGRID22974441 details
IRS1_HUMANSH2B1_HUMANBioGRID15316008 22974441 details
IRS1_HUMANPTPRU_HUMANBioGRID11781100 details
IRS1_HUMANP85B_HUMANBioGRID, HPRD11120660 12730242 23604317 30240640 7559478 details
IRS1_HUMANFBX25_HUMANBioGRID23940030 details
IRS1_HUMANMK03_HUMANBioGRID17640984 details
IRS1_HUMANTRI72_HUMANBioGRID27810898 29884820 32055715 details
IRS1_HUMANPASK_HUMANBioGRID9761740 details
IRS1_HUMANIRS1_HUMANBioGRID, HPRD10411883 8995282 details
IRS1_HUMANRAD51_HUMANBioGRID, HPRD14559999 details
IRS1_HUMANGRB14_HUMANHPRD9748281 details
IRS1_HUMANNTRK1_HUMANHPRD11147812 details
IRS1_HUMANPHIP_HUMANHPRD11018022 details
IRS1_HUMAN1433S_HUMANBioGRID, MINT15778465 details
IRS1_HUMANSIR1_HUMANBioGRID, UniProt17901049 21241768 details
IRS1_HUMANPABP1_HUMANMINT23770097 details
IRS1_HUMAN1433G_HUMANBioGRID, HPRD, IntAct15324660 28514442 30240640 details
IRS1_HUMAN1433F_HUMANBioGRID, IntAct11969417 28514442 30240640 details
IRS1_HUMANSOCS1_HUMANBioGRID, HPRD11208867 12228220 17276034 29991678 details
IRS1_HUMANIKKA_HUMANBioGRID, HPRD12351658 details
IRS1_HUMANIKKB_HUMANBioGRID, HPRD10722755 11606564 12351658 details
IRS1_HUMANBCL2_HUMANBioGRID10679027 details
IRS1_HUMANB2CL1_HUMANBioGRID, HPRD10679027 details
IRS1_HUMANJAK3_HUMANBioGRID, HPRD7499365 details
IRS1_HUMANNISCH_HUMANBioGRID11912194 details
IRS1_HUMANIRS2_HUMANBioGRID12554758 details
IRS1_HUMANUBF1_HUMANBioGRID, HPRD12554758 17332342 details
IRS1_HUMANALK_HUMANBioGRID, HPRD14968112 9174053 details
IRS1_HUMANCBLB_HUMANBioGRID16734387 29729186 details
IRS1_HUMANESR1_HUMANBioGRID12821935 details
IRS1_HUMANCBL_HUMANBioGRID10854852 29729186 details
IRS1_HUMANSOCS3_HUMANBioGRID, HPRD12228220 15514089 details
IRS1_HUMANPK3CB_HUMANBioGRID23604317 29526746 details
IRS1_HUMANDVL2_HUMANBioGRID24616100 details
IRS1_HUMANCUL7_HUMANBioGRID18498745 29269414 details
IRS1_HUMANCUL1_HUMANBioGRID30240640 details
IRS1_HUMANFBW1A_HUMANBioGRID30240640 details
IRS1_HUMANFBW1B_HUMANBioGRID30240640 details
IRS1_HUMAN1433T_HUMANBioGRID30240640 details
IRS1_HUMAN1433Z_HUMANBioGRID, HPRD30240640 9312143 details
IRS1_HUMANKC1A_HUMANBioGRID30240640 details
IRS1_HUMANCSK22_HUMANBioGRID30240640 details
IRS1_HUMANCSK2B_HUMANBioGRID, HPRD30240640 8349691 details
IRS1_HUMANGSK3B_HUMANBioGRID29526746 details
IRS1_HUMANCD36_HUMANBioGRID29269414 details
IRS1_HUMANFYN_HUMANBioGRID, HPRD29269414 8631859 details
IRS1_HUMANPTPRF_HUMANBioGRID, HPRD10660596 15588985 8732688 8995282 details
IRS1_HUMANCD2AP_HUMANBioGRID29729186 details
IRS1_HUMANUSP9X_HUMANBioGRID30338032 details
IRS1_HUMANKLHL9_HUMANBioGRID31515271 details
IRS1_HUMANKLH13_HUMANBioGRID31515271 details
IRS1_HUMANCUL3_HUMANBioGRID31515271 details
IRS1_HUMANAT2A1_HUMANHPRD9295312 details
IRS1_HUMANCSK21_HUMANHPRD8349691 details
IRS1_HUMANMK01_HUMANHPRD16131083 details
IRS1_HUMANNPM_HUMANHPRD8633037 details
IRS1_HUMANKPCT_HUMANHPRD15364919 details
IRS1_HUMANKPCG_HUMANHPRD15364919 details
IRS1_HUMANPDPK1_HUMANHPRD15802620 details
IRS1_HUMANAT2A2_HUMANHPRD9295312 details
IRS1_HUMANBCR_HUMANHPRD12560071 details
IRS1_HUMANCRK_HUMANHPRD8621590 8810325 9837978 details
IRS1_HUMANFER_HUMANHPRD11006284 details
IRS1_HUMANFES_HUMANHPRD10856136 details
IRS1_HUMANGHR_HUMANHPRD7782332 details
IRS1_HUMANCAV1_HUMANHPRD15003536 details
IRS1_HUMANROCK1_HUMANHPRD11739394 details
IRS1_HUMANAT2A3_HUMANHPRD12524443 details
IRS1_HUMANPTPRC_HUMANHPRD8557683 details
IRS1_HUMANTYK2_HUMANHPRD8550573 details
IRS1_HUMANKPCZ_HUMANHPRD11063744 details
IRS1_HUMANSHC1_HUMANHPRD7499194 details
IRS1_HUMANTUB_HUMANHPRD10455176 details
IRS1_HUMANMK09_HUMANHPRD12417588 details
IRS1_HUMANSIK2_HUMANHPRD12624099 details