Entity Details

Primary name AHR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35869
EntryNameAHR_HUMAN
FullNameAryl hydrocarbon receptor
TaxID9606
Evidenceevidence at protein level
Length848
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesAHR

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001094 TFIID-class transcription factor complex binding
GO:0001223 transcription coactivator binding
GO:0001568 blood vessel development
GO:0002819 regulation of adaptive immune response
GO:0002841 negative regulation of T cell mediated immune response to tumor cell
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006805 xenobiotic metabolic process
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0008134 transcription factor binding
GO:0009410 response to xenobiotic stimulus
GO:0009636 response to toxic substance
GO:0010468 regulation of gene expression
GO:0017025 TBP-class protein binding
GO:0019933 cAMP-mediated signaling
GO:0030888 regulation of B cell proliferation
GO:0032922 circadian regulation of gene expression
GO:0032991 protein-containing complex
GO:0034751 aryl hydrocarbon receptor complex
GO:0034752 cytosolic aryl hydrocarbon receptor complex
GO:0042803 protein homodimerization activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0051879 Hsp90 protein binding
GO:0070888 E-box binding
GO:0071320 cellular response to cAMP
GO:1904322 cellular response to forskolin
GO:1904613 cellular response to 2,3,7,8-tetrachlorodibenzodioxine
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000014 PAS domainDomainDomain
IPR001610 PAC motifRepeatRepeat
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR013655 PAS fold-3DomainDomain
IPR013767 PAS foldDomainDomain
IPR033348 Aryl hydrocarbon receptorFamilyFamily
IPR035965 PAS domain superfamilyFamilyHomologous superfamily
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR039091 Aryl hydrocarbon receptor/Aryl hydrocarbon receptor repressorFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00338 OmeprazoleDrugbanksmall molecule
DB00379 MexiletineDrugbanksmall molecule
DB00393 NimodipineDrugbanksmall molecule
DB00499 FlutamideDrugbanksmall molecule
DB01076 AtorvastatinDrugbanksmall molecule
DB01097 LeflunomideDrugbanksmall molecule
DB01404 GinsengDrugbanksmall molecule
DB02052 Indirubin-3'-monoximeDrugbanksmall molecule
DB02709 ResveratrolDrugbanksmall molecule
DB04216 QuercetinDrugbanksmall molecule
DB06732 beta-NaphthoflavoneDrugbanksmall molecule
DB07715 EmodinDrugbanksmall molecule
DB08624 1-[(4S)-4-amino-5-(1,3-benzothiazol-2-yl)-5-oxopentyl]guanidineDrugbanksmall molecule
DB08995 DiosminDrugbanksmall molecule
DB11577 Indigotindisulfonic acidDrugbanksmall molecule
DB11937 Kynurenic AcidDrugbanksmall molecule
DB12116 Epigallocatechin gallateDrugbanksmall molecule
DB12328 CantharidinDrugbanksmall molecule
DB12379 IndirubinDrugbanksmall molecule

Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
AHR_HUMANNCOA7_HUMANBioGRID, IntAct10395741 details
AHR_HUMANARNT_HUMANBioGRID, HPRD, IntAct10395741 10617682 10619402 10671489 11025203 11259609 11551916 11768231 12024042 12139968 17392787 18096572 19380484 19390533 20006590 22138065 23477502 26350169 28514442 31675361 7488247 7628454 8065341 8384309 8619634 8621524 8631989 9704006 9887096 details
AHR_HUMANNCOR2_HUMANBioGRID, HPRD, IntAct10395741 12139968 15325265 details
AHR_HUMANAIP_HUMANBioGRID, HPRD, IntAct10986286 11013261 12065584 16257957 16582008 7961671 9083006 9111057 9837941 details
AHR_HUMANRB_HUMANBioGRID, HPRD, IntAct10644764 11259609 18524851 9712901 details
AHR_HUMANEP300_HUMANBioGRID, HPRD, IntAct10999956 17392787 21988832 details
AHR_HUMANCCNT1_HUMANBioGRID, HPRD12917420 details
AHR_HUMANESR1_HUMANBioGRID, HPRD10620335 12612060 15837795 17392787 19460354 27420286 9611253 details
AHR_HUMANSMCA4_HUMANBioGRID11805098 details
AHR_HUMANNEDD8_HUMANBioGRID, HPRD12215427 details
AHR_HUMANNCOA2_HUMANBioGRID, HPRD12024042 15641800 details
AHR_HUMANRT29_HUMANBioGRID, HPRD10903152 details
AHR_HUMANSP1_HUMANBioGRID10471301 details
AHR_HUMANNRIP1_HUMANBioGRID, HPRD10428779 11551916 details
AHR_HUMANTBP_HUMANBioGRID, HPRD15641800 8794892 details
AHR_HUMANT2FB_HUMANBioGRID, HPRD8794892 details
AHR_HUMANT2FA_HUMANBioGRID8794892 details
AHR_HUMANBMAL1_HUMANBioGRID, HPRD9079689 details
AHR_HUMANCOT1_HUMANBioGRID, HPRD10620335 11368516 details
AHR_HUMANHS90A_HUMANBioGRID, HPRD10617682 11013261 18806268 7961671 9083006 9390191 details
AHR_HUMANCHIP_HUMANBioGRID12837759 17209571 details
AHR_HUMANAHR_HUMANBioGRID, HPRD10620335 18358233 details
AHR_HUMANNS1BP_HUMANBioGRID16582008 details
AHR_HUMANBRCA1_HUMANBioGRID18259752 details
AHR_HUMANTAF9_HUMANBioGRID15641800 details
AHR_HUMANTAF6_HUMANBioGRID15641800 details
AHR_HUMANTAF4_HUMANBioGRID, HPRD15641800 details
AHR_HUMANNCOA1_HUMANBioGRID, HPRD12024042 15641800 details
AHR_HUMANTEBP_HUMANBioGRID, HPRD11013261 11259606 details
AHR_HUMANARNT2_HUMANBioGRID18096572 details
AHR_HUMANCUL4B_HUMANBioGRID, HPRD17392787 details
AHR_HUMANTBL3_HUMANBioGRID17392787 details
AHR_HUMANTAF7_HUMANHPRD8794892 details
AHR_HUMANMAF_HUMANBioGRID, InnateDB20676092 20676095 details
AHR_HUMANCTNB1_HUMANBioGRID, DIP19651607 23174221 31675361 details
AHR_HUMANDDB1_HUMANBioGRID, DIP17392787 19651607 details
AHR_HUMANTF65_HUMANBioGRID, HPRD11114727 12181450 details
AHR_HUMANFOXA1_HUMANBioGRID22596188 details
AHR_HUMANNF2L2_HUMANBioGRID20395535 details
AHR_HUMANGNA13_HUMANBioGRID19390533 details
AHR_HUMANXPO1_HUMANBioGRID, HPRD12065584 26673895 details
AHR_HUMANANDR_HUMANBioGRID, HPRD17392787 25908644 details
AHR_HUMANVIME_HUMANBioGRID27752740 details
AHR_HUMANCSN5_HUMANBioGRID27060206 details
AHR_HUMANSMAD4_HUMANBioGRID27060206 details
AHR_HUMANMED1_HUMANBioGRID17392787 details
AHR_HUMANFHL2_HUMANBioGRID19015043 details
AHR_HUMANLAT1_HUMANBioGRID26944194 details
AHR_HUMANCP1B1_HUMANBioGRID26944194 details
AHR_HUMANE2F1_HUMANBioGRID18524851 details
AHR_HUMANSUV91_HUMANBioGRID31676321 details
AHR_HUMANUCHL3_HUMANBioGRID32546741 details