Entity Details

Primary name VGFR3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35916
EntryNameVGFR3_HUMAN
FullNameVascular endothelial growth factor receptor 3
TaxID9606
Evidenceevidence at protein level
Length1363
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesFLT4

GO terms

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GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001944 vasculature development
GO:0001945 lymph vessel development
GO:0001946 lymphangiogenesis
GO:0002040 sprouting angiogenesis
GO:0002244 hematopoietic progenitor cell differentiation
GO:0003016 respiratory system process
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0008284 positive regulation of cell population proliferation
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010595 positive regulation of endothelial cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019838 growth factor binding
GO:0019903 protein phosphatase binding
GO:0033674 positive regulation of kinase activity
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0046330 positive regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048286 lung alveolus development
GO:0048514 blood vessel morphogenesis
GO:0060312 regulation of blood vessel remodeling
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090037 positive regulation of protein kinase C signaling

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001824 Tyrosine-protein kinase, receptor class III, conserved siteSiteConserved site
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR009137 Vascular endothelial growth factor receptor 3 (VEGFR3)FamilyFamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR041348 VEGFR-2, Transmembrane domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00398 SorafenibDrugbanksmall molecule
DB01268 SunitinibDrugbanksmall molecule
DB04879 VatalanibDrugbanksmall molecule
DB05075 TG-100801Drugbanksmall molecule
DB05932 DenibulinDrugbanksmall molecule
DB06080 ABT-869Drugbanksmall molecule
DB06101 IMC-1C11Drugbankbiotech
DB06589 PazopanibDrugbanksmall molecule
DB06626 AxitinibDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB09078 LenvatinibDrugbanksmall molecule
DB09079 NintedanibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB15685 SelpercatinibDrugbanksmall molecule