Entity Details

Primary name FLT3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP36888
EntryNameFLT3_HUMAN
FullNameReceptor-type tyrosine-protein kinase FLT3
TaxID9606
Evidenceevidence at protein level
Length993
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesFLT3

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001776 leukocyte homeostasis
GO:0002318 myeloid progenitor cell differentiation
GO:0002328 pro-B cell differentiation
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004896 cytokine receptor activity
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0008284 positive regulation of cell population proliferation
GO:0010008 endosome membrane
GO:0010243 response to organonitrogen compound
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016032 viral process
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019838 growth factor binding
GO:0030097 hemopoiesis
GO:0030183 B cell differentiation
GO:0031100 animal organ regeneration
GO:0033674 positive regulation of kinase activity
GO:0035259 glucocorticoid receptor binding
GO:0035726 common myeloid progenitor cell proliferation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042981 regulation of apoptotic process
GO:0043235 receptor complex
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043621 protein self-association
GO:0044877 protein-containing complex binding
GO:0046651 lymphocyte proliferation
GO:0046777 protein autophosphorylation
GO:0051897 positive regulation of protein kinase B signaling
GO:0071345 cellular response to cytokine stimulus
GO:0071385 cellular response to glucocorticoid stimulus
GO:0097028 dendritic cell differentiation

Subcellular Location

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Subcellular Location
Endoplasmic reticulum lumen
Membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001824 Tyrosine-protein kinase, receptor class III, conserved siteSiteConserved site
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR030118 Receptor-type tyrosine-protein kinase FLT3FamilyFamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00398 SorafenibDrugbanksmall molecule
DB01268 SunitinibDrugbanksmall molecule
DB05014 XL999Drugbanksmall molecule
DB05465 TandutinibDrugbanksmall molecule
DB06080 ABT-869Drugbanksmall molecule
DB06469 LestaurtinibDrugbanksmall molecule
DB06595 MidostaurinDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB09079 NintedanibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12141 GilteritinibDrugbanksmall molecule
DB12267 BrigatinibDrugbanksmall molecule
DB12500 FedratinibDrugbanksmall molecule
DB12742 AmuvatinibDrugbanksmall molecule
DB12874 QuizartinibDrugbanksmall molecule
DB12978 PexidartinibDrugbanksmall molecule
DB15822 PralsetinibDrugbanksmall molecule

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
FLT3_HUMANPTN11_HUMANBioGRID, MINT16684964 details
FLT3_HUMANNEMO_HUMANBioGRID, IntAct20098747 details
FLT3_HUMANKSYK_HUMANIntAct, MINT24525236 28086240 details
FLT3_HUMANABL2_HUMANMINT28086240 details
FLT3_HUMANCRKL_HUMANMINT28086240 details
FLT3_HUMANCRK_HUMANMINT28086240 details
FLT3_HUMANFYN_HUMANMINT28086240 details
FLT3_HUMANABL1_HUMANMINT28086240 details
FLT3_HUMANLCK_HUMANMINT28086240 details
FLT3_HUMANSOCS6_HUMANMINT28086240 details
FLT3_HUMANRASA1_HUMANMINT28086240 details
FLT3_HUMANBLK_HUMANMINT28086240 details
FLT3_HUMANTENS1_HUMANMINT28086240 details
FLT3_HUMANYES_HUMANMINT28086240 details
FLT3_HUMANUB2L6_HUMANBioGRID20508617 details
FLT3_HUMANSIAH1_HUMANBioGRID20508617 details
FLT3_HUMANSLAP1_HUMANBioGRID23300935 details
FLT3_HUMANCBL_HUMANBioGRID17446348 details
FLT3_HUMANFLT3_HUMANBioGRID, HPRD11971190 21389326 details
FLT3_HUMANSRC_HUMANBioGRID16684964 details
FLT3_HUMANERBB2_HUMANBioGRID30898150 details
FLT3_HUMAN3BP2_HUMANHPRD10409713 details
FLT3_HUMANNCK1_HUMANHPRD10409713 details
FLT3_HUMANFIZ1_HUMANHPRD10409713 details
FLT3_HUMANP85A_HUMANBioGRID, MINT16982329 details
FLT3_HUMANPTPRJ_HUMANIntAct23650535 details
FLT3_HUMANGRB10_HUMANMINT23246379 details
FLT3_HUMANSOCS1_HUMANBioGRID, HPRD10022833 29991678 details
FLT3_HUMANGRB2_HUMANBioGRID, HPRD10080542 details
FLT3_HUMANHS90A_HUMANBioGRID18394702 details
FLT3_HUMANSOCS2_HUMANBioGRID23548639 details
FLT3_HUMANUBC_HUMANBioGRID30250637 details
FLT3_HUMANLYN_HUMANBioGRID16684964 details
FLT3_HUMANFGR_HUMANBioGRID16684964 details
FLT3_HUMANHCK_HUMANBioGRID16684964 details
FLT3_HUMANPTN6_HUMANHPRD15831474 details
FLT3_HUMANPTN12_HUMANHPRD15831474 details
FLT3_HUMANSHIP1_HUMANHPRD9918857 details
FLT3_HUMANFLT3L_HUMANHPRD7505204 9651358 details
FLT3_HUMANCBLB_HUMANHPRD9614102 details