Entity Details

Primary name IL6RB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP40189
EntryNameIL6RB_HUMAN
FullNameInterleukin-6 receptor subunit beta
TaxID9606
Evidenceevidence at protein level
Length918
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesIL6ST

GO terms

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GOName
GO:0002675 positive regulation of acute inflammatory response
GO:0002821 positive regulation of adaptive immune response
GO:0004896 cytokine receptor activity
GO:0004897 ciliary neurotrophic factor receptor activity
GO:0004921 interleukin-11 receptor activity
GO:0005127 ciliary neurotrophic factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005896 interleukin-6 receptor complex
GO:0005900 oncostatin-M receptor complex
GO:0005977 glycogen metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0009897 external side of plasma membrane
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0016020 membrane
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0019838 growth factor binding
GO:0019955 cytokine binding
GO:0019970 interleukin-11 binding
GO:0030425 dendrite
GO:0034097 response to cytokine
GO:0038165 oncostatin-M-mediated signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042802 identical protein binding
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0043235 receptor complex
GO:0045509 interleukin-27 receptor activity
GO:0045669 positive regulation of osteoblast differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0048711 positive regulation of astrocyte differentiation
GO:0048861 leukemia inhibitory factor signaling pathway
GO:0060576 intestinal epithelial cell development
GO:0070062 extracellular exosome
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070104 negative regulation of interleukin-6-mediated signaling pathway
GO:0070106 interleukin-27-mediated signaling pathway
GO:0070110 ciliary neurotrophic factor receptor complex
GO:0070120 ciliary neurotrophic factor-mediated signaling pathway
GO:0070757 interleukin-35-mediated signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR010457 Immunoglobulin C2-set-like, ligand-bindingDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015321 Type I cytokine receptor, cytokine-binding domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618523 OMIMHyper-IgE recurrent infection syndrome 4, autosomal recessive (HIES4)An immunologic disorder characterized by recurrent infections, mainly affecting the respiratory tract, skin and eye, and skeletal abnormalities including craniosynostosis and scoliosis. Immunologic workup shows increased serum IgE, intermittent eosinophilia, impaired development of certain B- and T-cell populations, as well as impaired acute-phase response. Disease onset is in early childhood. The disease is caused by variants affecting the gene represented in this entry.

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
IL6RB_HUMANCNTF_HUMANHPRD, IntAct, MINT12643274 16051226 18775332 details
IL6RB_HUMANONCM_HUMANBioGRID, HPRD, IntAct, MINT16051226 26186194 28514442 8999038 details
IL6RB_HUMANLIF_HUMANHPRD, IntAct, MINT12707269 14527405 16051226 details
IL6RB_HUMANSTAT1_HUMANMINT8662591 details
IL6RB_HUMANCMYA5_HUMANBioGRID, IntAct23414517 details
IL6RB_HUMANMAGAB_HUMANBioGRID, IntAct25416956 32296183 details
IL6RB_HUMANCSEN_HUMANBioGRID, IntAct25416956 32296183 details
IL6RB_HUMANSGTA_HUMANBioGRID, IntAct32296183 details
IL6RB_HUMANSGTB_HUMANBioGRID, IntAct25416956 29892012 32296183 details
IL6RB_HUMANKCIP1_HUMANBioGRID, IntAct32296183 details
IL6RB_HUMANJAK1_HUMANBioGRID, DIP, HPRD11468294 11742534 21220115 9388212 details
IL6RB_HUMANTLE1_HUMANBioGRID, HPRD12030375 details
IL6RB_HUMANCNTFR_HUMANBioGRID, HPRD11285233 12707266 details
IL6RB_HUMANPTN11_HUMANBioGRID, HPRD10777583 10946280 12403768 9195977 9388212 9794795 details
IL6RB_HUMANSOCS3_HUMANBioGRID, HPRD10777583 10946280 12403768 24438103 32548823 details
IL6RB_HUMANCDK9_HUMANBioGRID, HPRD12386808 details
IL6RB_HUMANVAV_HUMANBioGRID, HPRD9013873 details
IL6RB_HUMANGRB2_HUMANBioGRID9013873 details
IL6RB_HUMANSHC1_HUMANBioGRID9126968 details
IL6RB_HUMANUBQL1_HUMANBioGRID25416956 details
IL6RB_HUMANFBX2_HUMANBioGRID32549792 details
IL6RB_HUMANIL6_HUMANHPRD, IntAct12829785 14557255 18775332 details
IL6RB_HUMANIL6RA_HUMANBioGRID, HPRD, UniProt11238858 2788034 details
IL6RB_HUMANIL6RB_HUMANDIP, HPRD, IntAct11251120 19020503 24501689 details
IL6RB_HUMANOSMR_HUMANBioGRID, HPRD, IntAct24501689 8999038 9188471 details
IL6RB_HUMANANDR_HUMANBioGRID, HPRD15129430 details
IL6RB_HUMANLIFR_HUMANBioGRID, HPRD12047380 8999038 details
IL6RB_HUMANHCK_HUMANBioGRID, HPRD11689697 details
IL6RB_HUMANERBB2_HUMANBioGRID, HPRD11821958 details
IL6RB_HUMANERBB3_HUMANBioGRID, HPRD11821958 details
IL6RB_HUMANJAK2_HUMANBioGRID9388212 details
IL6RB_HUMANTYK2_HUMANBioGRID, HPRD9388212 details
IL6RB_HUMANKPCD_HUMANBioGRID, HPRD12361954 details
IL6RB_HUMANSTAT3_HUMANBioGRID, HPRD12361954 details
IL6RB_HUMANP85A_HUMANBioGRID10579793 details
IL6RB_HUMANPTN6_HUMANBioGRID, HPRD10800945 details
IL6RB_HUMANCTF1_HUMANHPRD11834704 details
IL6RB_HUMANPK3CG_HUMANHPRD10579793 details
IL6RB_HUMANIL31R_HUMANHPRD14504285 15184896 details
IL6RB_HUMANUPAR_HUMANHPRD9353320 details