Entity Details

Primary name UBP8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP40818
EntryNameUBP8_HUMAN
FullNameUbiquitin carboxyl-terminal hydrolase 8
TaxID9606
Evidenceevidence at protein level
Length1118
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesUSP8

GO terms

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GOName
GO:0000281 mitotic cytokinesis
GO:0004197 cysteine-type endopeptidase activity
GO:0004843 thiol-dependent deubiquitinase
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005829 cytosol
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007032 endosome organization
GO:0007265 Ras protein signal transduction
GO:0014069 postsynaptic density
GO:0016579 protein deubiquitination
GO:0017124 SH3 domain binding
GO:0019897 extrinsic component of plasma membrane
GO:0030496 midbody
GO:0031313 extrinsic component of endosome membrane
GO:0031647 regulation of protein stability
GO:0032880 regulation of protein localization
GO:0043197 dendritic spine
GO:0045296 cadherin binding
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
GO:0071549 cellular response to dexamethasone stimulus
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0098978 glutamatergic synapse
GO:0099576 regulation of protein catabolic process at postsynapse, modulating synaptic transmission
GO:1990090 cellular response to nerve growth factor stimulus

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endosome membrane
Nucleus

Domains

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DomainNameCategoryType
IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolaseDomainDomain
IPR001763 Rhodanese-like domainDomainDomain
IPR015063 USP8 dimerisation domainDomainDomain
IPR018200 Ubiquitin specific protease, conserved siteSiteConserved site
IPR028889 Ubiquitin specific protease domainDomainDomain
IPR036873 Rhodanese-like domain superfamilyFamilyHomologous superfamily
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily

Diseases

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Interactions

79 interactions

InteractorPartnerSourcesPublicationsLink
UBP8_HUMAN1433T_HUMANBioGRID, HPRD, IntAct, MINT15161933 15324660 17353931 23333852 28514442 details
UBP8_HUMAN1433Z_HUMANBioGRID, IntAct, MINT15161933 15324660 17353931 28514442 29473952 details
UBP8_HUMANCHM1B_HUMANBioGRID, MINT, UniProt17711858 19302785 details
UBP8_HUMANCHM1A_HUMANBioGRID, MINT, UniProt17711858 19302785 details
UBP8_HUMANCHM4C_HUMANBioGRID, MINT, UniProt17711858 19302785 details
UBP8_HUMANCHM2A_HUMANBioGRID, MINT19302785 details
UBP8_HUMANCHM2B_HUMANBioGRID, MINT19302785 details
UBP8_HUMANCHMP3_HUMANMINT19302785 details
UBP8_HUMANCHM4B_HUMANMINT19302785 details
UBP8_HUMANCHMP5_HUMANMINT19302785 details
UBP8_HUMANCHMP6_HUMANMINT19302785 details
UBP8_HUMANNBR1_HUMANBioGRID, MINT19427866 details
UBP8_HUMANHIF1A_HUMANMINT24378640 details
UBP8_HUMANEPAS1_HUMANMINT24378640 details
UBP8_HUMANGRAP2_HUMANBioGRID, HPRD, IntAct12176364 12773374 26186194 26214742 28514442 details
UBP8_HUMANRNF41_HUMANBioGRID, HPRD15314180 17035239 23750007 28973533 29560723 details
UBP8_HUMANSTAM2_HUMANBioGRID, HPRD10982817 13129930 20736164 29604273 details
UBP8_HUMANSTAM1_HUMANBioGRID, HPRD10982817 16520378 20736164 29604273 details
UBP8_HUMANGRB2_HUMANBioGRID, HPRD10982817 13129930 details
UBP8_HUMANEPS15_HUMANBioGRID16771824 details
UBP8_HUMANEGFR_HUMANBioGRID16120644 23153581 23333852 23477725 25485838 25853104 details
UBP8_HUMANCHMP7_HUMANBioGRID17711858 details
UBP8_HUMANOSTP_HUMANBioGRID22779921 details
UBP8_HUMANUBC_HUMANBioGRID17711858 22195557 23287719 25485838 25527291 27501351 29576527 details
UBP8_HUMANPJA1_HUMANBioGRID22626734 details
UBP8_HUMANTRI63_HUMANBioGRID22626734 details
UBP8_HUMANTRI55_HUMANBioGRID22626734 details
UBP8_HUMANTRI54_HUMANBioGRID22626734 details
UBP8_HUMANUBP21_HUMANBioGRID22626734 details
UBP8_HUMANUBP15_HUMANBioGRID22626734 details
UBP8_HUMANUBP28_HUMANBioGRID22626734 details
UBP8_HUMANSRC_HUMANBioGRID23333852 details
UBP8_HUMAN1433E_HUMANBioGRID17979178 19608861 23472066 25485838 25675982 details
UBP8_HUMANTADBP_HUMANBioGRID24825905 details
UBP8_HUMANPA2GA_HUMANBioGRID22118674 details
UBP8_HUMANH2A2C_HUMANBioGRID26507658 details
UBP8_HUMANH2B2E_HUMANBioGRID26507658 details
UBP8_HUMANBACE1_HUMANBioGRID27302062 details
UBP8_HUMANSYUA_HUMANBioGRID27444016 details
UBP8_HUMANCFLAR_HUMANBioGRID27321185 31443721 details
UBP8_HUMANMAGL2_HUMANBioGRID28973533 details
UBP8_HUMANSC31A_HUMANBioGRID29604273 details
UBP8_HUMANSHAN1_HUMANBioGRID29735556 details
UBP8_HUMANSQSTM_HUMANBioGRID31241013 details
UBP8_HUMANRGRF1_HUMANHPRD11500497 details
UBP8_HUMAN1433G_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 28514442 details
UBP8_HUMAN1433B_HUMANBioGRID, IntAct, MINT15324660 17353931 24255178 26214742 28514442 details
UBP8_HUMAN1433S_HUMANBioGRID, MINT15778465 29880877 details
UBP8_HUMANCBY1_HUMANBioGRID, IntAct27173435 unassigned1312 details
UBP8_HUMANRAB3I_HUMANBioGRID, IntAct27173435 unassigned1312 details
UBP8_HUMANOTUB1_HUMANBioGRID14661020 details
UBP8_HUMANRN128_HUMANBioGRID14661020 details
UBP8_HUMANKIF23_HUMANBioGRID, HPRD18329369 details
UBP8_HUMANBIRC6_HUMANBioGRID, HPRD18329369 25733871 26683461 details
UBP8_HUMANAKT1_HUMANBioGRID17210635 details
UBP8_HUMANKCNN4_HUMANBioGRID21828287 details
UBP8_HUMANUBP8_HUMANBioGRID, HPRD10982817 17035239 details
UBP8_HUMANERBB4_HUMANBioGRID23153581 details
UBP8_HUMANPTN23_HUMANBioGRID23477725 details
UBP8_HUMANPTEN_HUMANBioGRID24270891 details
UBP8_HUMANLRIG1_HUMANBioGRID24828152 details
UBP8_HUMANVAMP8_HUMANBioGRID18388320 details
UBP8_HUMANSCNNA_HUMANBioGRID23297398 details
UBP8_HUMANSCNNB_HUMANBioGRID23297398 details
UBP8_HUMANSCNNG_HUMANBioGRID23297398 details
UBP8_HUMANMCPH1_HUMANBioGRID25733871 details
UBP8_HUMANEEA1_HUMANBioGRID29880877 details
UBP8_HUMANPP1A_HUMANBioGRID29880877 details
UBP8_HUMANPTPA_HUMANBioGRID29880877 details
UBP8_HUMANCXA1_HUMANBioGRID29626091 34079125 details
UBP8_HUMANEPG5_HUMANBioGRID30931944 details
UBP8_HUMANLEPR_HUMANBioGRID31199479 details
UBP8_HUMANERBB3_HUMANBioGRID31443721 details
UBP8_HUMANNOTC1_HUMANBioGRID31527799 details
UBP8_HUMANP63_HUMANBioGRID31511647 details
UBP8_HUMANTMM79_HUMANBioGRID32924931 details
UBP8_HUMANFZD5_HUMANBioGRID32924931 details
UBP8_HUMANSLBP_HUMANHPRD10982817 details
UBP8_HUMANDNJB6_HUMANHPRD15342353 details