Entity Details

Primary name GARS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41250
EntryNameGARS_HUMAN
FullNameGlycine--tRNA ligase
TaxID9606
Evidenceevidence at protein level
Length739
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesGARS1

GO terms

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GOName
GO:0004081 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
GO:0004820 glycine-tRNA ligase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006418 tRNA aminoacylation for protein translation
GO:0006426 glycyl-tRNA aminoacylation
GO:0015966 diadenosine tetraphosphate biosynthetic process
GO:0016740 transferase activity
GO:0030424 axon
GO:0042802 identical protein binding
GO:0046983 protein dimerization activity
GO:0070062 extracellular exosome
GO:0070150 mitochondrial glycyl-tRNA aminoacylation

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Mitochondrion
Secreted

Domains

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DomainNameCategoryType
IPR000738 WHEP-TRS domainDomainDomain
IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)DomainDomain
IPR002315 Glycyl-tRNA synthetaseFamilyFamily
IPR004154 Anticodon-bindingDomainDomain
IPR006195 Aminoacyl-tRNA synthetase, class IIDomainDomain
IPR009068 S15/NS1, RNA-bindingFamilyHomologous superfamily
IPR027031 Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2FamilyFamily
IPR033731 Glycyl-tRNA synthetase-like core domainDomainDomain
IPR036621 Anticodon-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00145 GlycineDrugbanksmall molecule