Entity Details

Primary name GRM5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41594
EntryNameGRM5_HUMAN
FullNameMetabotropic glutamate receptor 5
TaxID9606
Evidenceevidence at protein level
Length1212
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesGRM5

GO terms

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GOName
GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
GO:0001932 regulation of protein phosphorylation
GO:0004930 G protein-coupled receptor activity
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006417 regulation of translation
GO:0006448 regulation of translational elongation
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007206 phospholipase C-activating G protein-coupled glutamate receptor signaling pathway
GO:0007216 G protein-coupled glutamate receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007611 learning or memory
GO:0007612 learning
GO:0007626 locomotory behavior
GO:0008066 glutamate receptor activity
GO:0030296 protein tyrosine kinase activator activity
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0050808 synapse organization
GO:0050890 cognition
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0090647 modulation of age-related behavioral decline
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098839 postsynaptic density membrane
GO:0099170 postsynaptic modulation of chemical synaptic transmission
GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
GO:0099553 trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
GO:1902938 regulation of intracellular calcium activated chloride channel activity
GO:1904646 cellular response to amyloid-beta
GO:1990782 protein tyrosine kinase binding

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000162 GPCR, family 3, metabotropic glutamate receptorFamilyFamily
IPR000202 GPCR, family 3, metabotropic glutamate receptor 5FamilyFamily
IPR000337 GPCR, family 3FamilyFamily
IPR001828 Receptor, ligand binding regionDomainDomain
IPR011500 GPCR, family 3, nine cysteines domainDomainDomain
IPR017978 GPCR family 3, C-terminalDomainDomain
IPR017979 GPCR, family 3, conserved siteSiteConserved site
IPR019588 Metabotropic glutamate receptor, Homer-binding domainDomainDomain
IPR028082 Periplasmic binding protein-like IFamilyHomologous superfamily
IPR038550 GPCR, family 3, nine cysteines domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00659 AcamprosateDrugbanksmall molecule
DB05070 ADX10059Drugbanksmall molecule
DB06201 RufinamideDrugbanksmall molecule
DB12733 DipraglurantDrugbanksmall molecule