Entity Details

Primary name MC3R_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41968
EntryNameMC3R_HUMAN
FullNameMelanocortin receptor 3
TaxID9606
Evidenceevidence at protein level
Length323
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesMC3R

GO terms

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GOName
GO:0002027 regulation of heart rate
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004930 G protein-coupled receptor activity
GO:0004977 melanocortin receptor activity
GO:0004980 melanocyte-stimulating hormone receptor activity
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0008217 regulation of blood pressure
GO:0017046 peptide hormone binding
GO:0019222 regulation of metabolic process
GO:0032922 circadian regulation of gene expression
GO:0042309 homoiothermy
GO:0042923 neuropeptide binding
GO:0045475 locomotor rhythm
GO:0055078 sodium ion homeostasis
GO:0060259 regulation of feeding behavior

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR001671 Melanocortin/ACTH receptorFamilyFamily
IPR001908 Melanocortin receptorFamilyFamily
IPR002122 Melanocortin 3 receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB11653 BremelanotideDrugbanksmall molecule