Entity Details

Primary name CD86_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42081
EntryNameCD86_HUMAN
FullNameT-lymphocyte activation antigen CD86
TaxID9606
Evidenceevidence at protein level
Length329
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesCD86

GO terms

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GOName
GO:0001618 virus receptor activity
GO:0002250 adaptive immune response
GO:0002639 positive regulation of immunoglobulin production
GO:0005886 plasma membrane
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0008284 positive regulation of cell population proliferation
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0015026 coreceptor activity
GO:0016021 integral component of membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0023035 CD40 signaling pathway
GO:0031295 T cell costimulation
GO:0032743 positive regulation of interleukin-2 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032761 positive regulation of lymphotoxin A production
GO:0034451 centriolar satellite
GO:0038023 signaling receptor activity
GO:0042102 positive regulation of T cell proliferation
GO:0042113 B cell activation
GO:0042130 negative regulation of T cell proliferation
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051897 positive regulation of protein kinase B signaling
GO:0070062 extracellular exosome
GO:0071222 cellular response to lipopolysaccharide
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1990051 activation of protein kinase C activity

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013106 Immunoglobulin V-set domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR037677 CD86, IgV domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00098 Antithymocyte immunoglobulin (rabbit)Drugbankbiotech
DB01281 AbataceptDrugbankbiotech
DB06681 BelataceptDrugbankbiotech
DB11752 Bryostatin 1Drugbanksmall molecule