Entity Details

Primary name GRIA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42262
EntryNameGRIA2_HUMAN
FullNameGlutamate receptor 2
TaxID9606
Evidenceevidence at protein level
Length883
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesGRIA2

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0004970 ionotropic glutamate receptor activity
GO:0004971 AMPA glutamate receptor activity
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007165 signal transduction
GO:0007268 chemical synaptic transmission
GO:0009897 external side of plasma membrane
GO:0014069 postsynaptic density
GO:0015276 ligand-gated ion channel activity
GO:0030425 dendrite
GO:0030666 endocytic vesicle membrane
GO:0032279 asymmetric synapse
GO:0032281 AMPA glutamate receptor complex
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
GO:0038023 signaling receptor activity
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0060076 excitatory synapse
GO:0098794 postsynapse
GO:0098839 postsynaptic density membrane
GO:0098843 postsynaptic endocytic zone
GO:2000310 regulation of NMDA receptor activity

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001320 Ionotropic glutamate receptorDomainDomain
IPR001508 Ionotropic glutamate receptor, metazoaFamilyFamily
IPR001828 Receptor, ligand binding regionDomainDomain
IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domainDomainDomain
IPR028082 Periplasmic binding protein-like IFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00142 Glutamic acidDrugbanksmall molecule
DB00237 ButabarbitalDrugbanksmall molecule
DB00241 ButalbitalDrugbanksmall molecule
DB00306 TalbutalDrugbanksmall molecule
DB00312 PentobarbitalDrugbanksmall molecule
DB00418 SecobarbitalDrugbanksmall molecule
DB00463 MetharbitalDrugbanksmall molecule
DB00599 ThiopentalDrugbanksmall molecule
DB00794 PrimidoneDrugbanksmall molecule
DB00849 MethylphenobarbitalDrugbanksmall molecule
DB00898 EthanolDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB01346 Quinidine barbiturateDrugbanksmall molecule
DB01351 AmobarbitalDrugbanksmall molecule
DB01352 AprobarbitalDrugbanksmall molecule
DB01353 ButobarbitalDrugbanksmall molecule
DB01354 HeptabarbitalDrugbanksmall molecule
DB01355 HexobarbitalDrugbanksmall molecule
DB01483 BarbitalDrugbanksmall molecule
DB01496 Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedioneDrugbanksmall molecule
DB01664 (S)-DES-ME-AMPADrugbanksmall molecule
DB02057 (S)-AMPADrugbanksmall molecule
DB02347 2-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic AcidDrugbanksmall molecule
DB02818 Iodo-WillardiineDrugbanksmall molecule
DB02966 Fluoro-WillardiineDrugbanksmall molecule
DB02999 Quisqualic acidDrugbanksmall molecule
DB03240 (S)-2-Amino-3-(1,3,5,7-Pentahydro-2,4-Dioxo-Cyclopenta[E]Pyrimidin-1-Yl) Proionic AcidDrugbanksmall molecule
DB03319 (2S)-2-Ammonio-3-[5-(2-methyl-2-propanyl)-3-oxido-1,2-oxazol-4-yl]propanoateDrugbanksmall molecule
DB03759 FG-9041Drugbanksmall molecule
DB04000 Bromo-WillardiineDrugbanksmall molecule
DB04129 WillardiineDrugbanksmall molecule
DB04152 2-Amino-3-(3-Hydroxy-7,8-Dihydro-6h-Cyclohepta[D]-4-Isoxazolyl)Propionic AcidDrugbanksmall molecule
DB04599 AniracetamDrugbanksmall molecule
DB04798 THIO-ATPADrugbanksmall molecule
DB04982 TalampanelDrugbanksmall molecule
DB05047 CX-717Drugbanksmall molecule
DB07455 N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dimethanesulfonamideDrugbanksmall molecule
DB07598 2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONEDrugbanksmall molecule
DB08303 (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxideDrugbanksmall molecule
DB08304 (3R)-3-cyclopentyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxideDrugbanksmall molecule
DB08305 (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxideDrugbanksmall molecule
DB13146 Fluciclovine (18F)Drugbanksmall molecule