Entity Details

Primary name MTHR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42898
EntryNameMTHR_HUMAN
FullNameMethylenetetrahydrofolate reductase
TaxID9606
Evidenceevidence at protein level
Length656
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesMTHFR

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0001843 neural tube closure
GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity
GO:0005829 cytosol
GO:0006555 methionine metabolic process
GO:0009086 methionine biosynthetic process
GO:0031060 regulation of histone methylation
GO:0033274 response to vitamin B2
GO:0035999 tetrahydrofolate interconversion
GO:0042493 response to drug
GO:0043200 response to amino acid
GO:0044877 protein-containing complex binding
GO:0045202 synapse
GO:0046500 S-adenosylmethionine metabolic process
GO:0046655 folic acid metabolic process
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
GO:0050667 homocysteine metabolic process
GO:0051593 response to folic acid
GO:0070555 response to interleukin-1
GO:0070829 heterochromatin maintenance
GO:0071949 FAD binding
GO:0072341 modified amino acid binding
GO:0106312 methylenetetrahydrofolate reductase NADH activity
GO:0106313 methylenetetrahydrofolate reductase NADPH activity

Subcellular Location

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Domains

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DomainNameCategoryType
IPR003171 Methylenetetrahydrofolate reductase-likeFamilyFamily
IPR004621 Eukaryotic-type methylenetetrahydrofolate reductaseFamilyFamily
IPR029041 FAD-linked oxidoreductase-likeFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00115 CyanocobalaminDrugbanksmall molecule
DB00116 Tetrahydrofolic acidDrugbanksmall molecule
DB00134 MethionineDrugbanksmall molecule
DB00140 RiboflavinDrugbanksmall molecule
DB00158 Folic acidDrugbanksmall molecule
DB00170 MenadioneDrugbanksmall molecule
DB00542 BenazeprilDrugbanksmall molecule
DB00544 FluorouracilDrugbanksmall molecule
DB00563 MethotrexateDrugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
MTHR_HUMANLSM8_HUMANBioGRID, HPRD, IntAct15231747 details
MTHR_HUMANMTHR_HUMANBioGRID19610625 details
MTHR_HUMANTULP3_HUMANBioGRID33187986 details