Entity Details

Primary name SDF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP48061
EntryNameSDF1_HUMAN
FullNameStromal cell-derived factor 1
TaxID9606
Evidenceevidence at protein level
Length93
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesCXCL12

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0001764 neuron migration
GO:0001938 positive regulation of endothelial cell proliferation
GO:0005102 signaling receptor binding
GO:0005178 integrin binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006874 cellular calcium ion homeostasis
GO:0006935 chemotaxis
GO:0006952 defense response
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007411 axon guidance
GO:0008009 chemokine activity
GO:0008015 blood circulation
GO:0008064 regulation of actin polymerization or depolymerization
GO:0008083 growth factor activity
GO:0008344 adult locomotory behavior
GO:0009314 response to radiation
GO:0009408 response to heat
GO:0009615 response to virus
GO:0009897 external side of plasma membrane
GO:0010818 T cell chemotaxis
GO:0016032 viral process
GO:0022029 telencephalon cell migration
GO:0030335 positive regulation of cell migration
GO:0031100 animal organ regeneration
GO:0031640 killing of cells of other organism
GO:0033603 positive regulation of dopamine secretion
GO:0033622 integrin activation
GO:0038146 chemokine (C-X-C motif) ligand 12 signaling pathway
GO:0042379 chemokine receptor binding
GO:0043434 response to peptide hormone
GO:0045236 CXCR chemokine receptor binding
GO:0045666 positive regulation of neuron differentiation
GO:0045785 positive regulation of cell adhesion
GO:0048842 positive regulation of axon extension involved in axon guidance
GO:0050930 induction of positive chemotaxis
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0060326 cell chemotaxis
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070098 chemokine-mediated signaling pathway
GO:0090026 positive regulation of monocyte chemotaxis
GO:0090280 positive regulation of calcium ion import
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1903237 negative regulation of leukocyte tethering or rolling
GO:1990478 response to ultrasound
GO:1990869 cellular response to chemokine
GO:2000406 positive regulation of T cell migration
GO:2000669 negative regulation of dendritic cell apoptotic process

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001811 Chemokine interleukin-8-like domainDomainDomain
IPR033899 CXC Chemokine domainDomainDomain
IPR036048 Chemokine interleukin-8-like superfamilyFamilyHomologous superfamily
IPR039813 Stromal cell-derived factor 1FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB05934 CTCE-0214Drugbanksmall molecule
DB06822 TinzaparinDrugbanksmall molecule

Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
SDF1_HUMANDPP8_HUMANMINT18275857 details
SDF1_HUMANDPP4_HUMANHPRD, MINT11390394 18275857 21314817 details
SDF1_HUMANDAZP2_HUMANBioGRID, IntAct21988832 details
SDF1_HUMANCCL5_HUMANbhf-ucl, BioGRID28381538 details
SDF1_HUMANPLF4_HUMANbhf-ucl, BioGRID10233851 28381538 details
SDF1_HUMANCCL13_HUMANbhf-ucl, BioGRID28381538 details
SDF1_HUMANCCL11_HUMANbhf-ucl, BioGRID28381538 details
SDF1_HUMANCCL21_HUMANbhf-ucl, BioGRID28381538 details
SDF1_HUMANCXL11_HUMANbhf-ucl, BioGRID28381538 details
SDF1_HUMANCCL25_HUMANbhf-ucl, BioGRID28381538 details
SDF1_HUMANCXL17_HUMANbhf-ucl, BioGRID28381538 details
SDF1_HUMANCXL14_HUMANbhf-ucl, BioGRID28381538 details
SDF1_HUMANSDF1_HUMANbhf-ucl, BioGRID, HPRD10954912 28381538 9618518 details
SDF1_HUMANCCL20_HUMANbhf-ucl, BioGRID28381538 details
SDF1_HUMANCXL10_HUMANbhf-ucl, BioGRID28381538 details
SDF1_HUMANCXCL9_HUMANbhf-ucl, BioGRID28381538 details
SDF1_HUMANCXCL6_HUMANbhf-ucl, BioGRID28381538 details
SDF1_HUMANPF4V_HUMANbhf-ucl, BioGRID28381538 details
SDF1_HUMANCXCL2_HUMANbhf-ucl, BioGRID28381538 details
SDF1_HUMANXCL2_HUMANbhf-ucl, BioGRID28381538 details
SDF1_HUMANXCL1_HUMANbhf-ucl, BioGRID28381538 details
SDF1_HUMANCCL28_HUMANbhf-ucl, BioGRID28381538 details
SDF1_HUMANCCL26_HUMANbhf-ucl, BioGRID28381538 details
SDF1_HUMANCXCL7_HUMANbhf-ucl, BioGRID28381538 details
SDF1_HUMANFINC_HUMANBioGRID, HPRD11023498 details
SDF1_HUMANCSPG2_HUMANBioGRID11083865 details
SDF1_HUMANFBX7_HUMANBioGRID27503909 details
SDF1_HUMANCXCR4_HUMANBioGRID, HPRD10233851 21757744 25495026 8752281 details
SDF1_HUMANHMGB1_HUMANBioGRID25495026 details
SDF1_HUMANITAV_HUMANBioGRID23381805 details
SDF1_HUMANCD4_HUMANHPRD10600606 details
SDF1_HUMANCATG_HUMANHPRD11241273 details
SDF1_HUMANMMP2_HUMANHPRD11571304 details
SDF1_HUMANELNE_HUMANHPRD12068293 details