Entity Details

Primary name JAK3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP52333
EntryNameJAK3_HUMAN
FullNameTyrosine-protein kinase JAK3
TaxID9606
Evidenceevidence at protein level
Length1124
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesJAK3

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0002250 adaptive immune response
GO:0002731 negative regulation of dendritic cell cytokine production
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005768 endosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019903 protein phosphatase binding
GO:0030183 B cell differentiation
GO:0030218 erythrocyte differentiation
GO:0032693 negative regulation of interleukin-10 production
GO:0032695 negative regulation of interleukin-12 production
GO:0035556 intracellular signal transduction
GO:0035723 interleukin-15-mediated signaling pathway
GO:0035771 interleukin-4-mediated signaling pathway
GO:0038110 interleukin-2-mediated signaling pathway
GO:0038111 interleukin-7-mediated signaling pathway
GO:0038113 interleukin-9-mediated signaling pathway
GO:0038114 interleukin-21-mediated signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0042981 regulation of apoptotic process
GO:0043029 T cell homeostasis
GO:0045087 innate immune response
GO:0045221 negative regulation of FasL production
GO:0045626 negative regulation of T-helper 1 cell differentiation
GO:0046425 regulation of receptor signaling pathway via JAK-STAT
GO:0050868 negative regulation of T cell activation
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
GO:0070232 regulation of T cell apoptotic process
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0070669 response to interleukin-2
GO:0070670 response to interleukin-4
GO:0070672 response to interleukin-15
GO:0071104 response to interleukin-9

Subcellular Location

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Subcellular Location
Cytoplasm
Endomembrane system

Domains

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DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR019749 Band 4.1 domainDomainDomain
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR020775 Tyrosine-protein kinase, non-receptor Jak3FamilyFamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR041046 JAK, FERM F2 lobe domainDomainDomain
IPR041155 FERM F1 lobe ubiquitin-like domainDomainDomain
IPR041381 Jak1, pleckstrin homology-like domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB04716 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-oneDrugbanksmall molecule
DB06321 R-348Drugbanksmall molecule
DB08895 TofacitinibDrugbanksmall molecule
DB11817 BaricitinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB15035 ZanubrutinibDrugbanksmall molecule

Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
JAK3_HUMANERBB3_HUMANBioGRID, MINT16273093 details
JAK3_HUMANCDK1_HUMANBioGRID, IntAct21988832 details
JAK3_HUMANTF2B_HUMANBioGRID, IntAct21988832 details
JAK3_HUMANCD81_HUMANBioGRID, IntAct21988832 details
JAK3_HUMANAPOA1_HUMANBioGRID, IntAct21988832 details
JAK3_HUMANNEMO_HUMANBioGRID, IntAct20098747 details
JAK3_HUMANUHRF2_HUMANBioGRID, UniProt21952639 details
JAK3_HUMANNFAC1_HUMANInnateDB23263556 details
JAK3_HUMANLNX1_HUMANBioGRID, IntAct25814554 details
JAK3_HUMANTIAF1_HUMANBioGRID, HPRD10733938 details
JAK3_HUMANSTA5A_HUMANBioGRID, HPRD10037026 18250158 9047382 details
JAK3_HUMANANM5_HUMANBioGRID, HPRD10531356 details
JAK3_HUMANSHB_HUMANBioGRID, HPRD12200137 details
JAK3_HUMANSTA5B_HUMANBioGRID9047382 details
JAK3_HUMANCD3Z_HUMANBioGRID, HPRD11349123 details
JAK3_HUMANJAK1_HUMANBioGRID, HPRD12207328 12559972 32001089 9553136 details
JAK3_HUMANKIT_HUMANBioGRID17554063 details
JAK3_HUMANSOCS1_HUMANBioGRID, HPRD11133764 27144517 29674694 29991678 details
JAK3_HUMANKHDR1_HUMANHPRD, IntAct9045636 details
JAK3_HUMANROCK2_HUMANIntAct30413785 details
JAK3_HUMANFAK2_HUMANBioGRID, HPRD9512511 details
JAK3_HUMANCXCR4_HUMANBioGRID, HPRD10506573 details
JAK3_HUMANIL2RG_HUMANBioGRID, HPRD27742835 7973658 7973659 details
JAK3_HUMANALK_HUMANBioGRID, HPRD11850821 14968112 details
JAK3_HUMANIRS1_HUMANBioGRID, HPRD7499365 details
JAK3_HUMANCD3E_HUMANBioGRID11349123 details
JAK3_HUMANSTAM1_HUMANBioGRID, HPRD10899310 9133424 details
JAK3_HUMANSTAM2_HUMANBioGRID, HPRD10899310 details
JAK3_HUMANSOCS3_HUMANBioGRID, HPRD10373548 15385932 details
JAK3_HUMANIL4RA_HUMANBioGRID, HPRD12207328 7538655 details
JAK3_HUMANJAK2_HUMANBioGRID, HPRD11585385 12207328 details
JAK3_HUMANTYK2_HUMANBioGRID12207328 details
JAK3_HUMANSTAT3_HUMANBioGRID, HPRD10037026 12207328 details
JAK3_HUMANSTAT6_HUMANBioGRID12207328 details
JAK3_HUMANIL7RA_HUMANBioGRID, HPRD15996891 17554063 7481769 details
JAK3_HUMANIL2RB_HUMANBioGRID, HPRD10825200 20816854 7973659 9553136 details
JAK3_HUMANJAK3_HUMANHPRD15121872 9391116 details
JAK3_HUMANIRS2_HUMANHPRD7499365 details
JAK3_HUMANPTN2_HUMANHPRD11909529 15588985 details
JAK3_HUMANSH2B2_HUMANHPRD10872802 details
JAK3_HUMANP85A_HUMANHPRD7662955 details
JAK3_HUMANPTN6_HUMANHPRD9520455 details
JAK3_HUMANFES_HUMANHPRD11160325 details
JAK3_HUMANSHIP1_HUMANHPRD10875931 details
JAK3_HUMANTNR5_HUMANHPRD10395671 9133417 details
JAK3_HUMANVILI_HUMANHPRD17537734 details
JAK3_HUMANPTPRC_HUMANHPRD11994288 details
JAK3_HUMANLCK_HUMANHPRD11278738 details