Entity Details

Primary name HAND2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP61296
EntryNameHAND2_HUMAN
FullNameHeart- and neural crest derivatives-expressed protein 2
TaxID9606
Evidenceevidence at protein level
Length217
SequenceStatuscomplete
DateCreated2004-05-10
DateModified2021-06-02

Ontological Relatives

GenesHAND2

GO terms

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GOName
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001525 angiogenesis
GO:0001701 in utero embryonic development
GO:0001947 heart looping
GO:0001967 suckling behavior
GO:0003219 cardiac right ventricle formation
GO:0003253 cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0003266 regulation of secondary heart field cardioblast proliferation
GO:0003278 apoptotic process involved in heart morphogenesis
GO:0003357 noradrenergic neuron differentiation
GO:0003680 minor groove of adenine-thymine-rich DNA binding
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007507 heart development
GO:0007512 adult heart development
GO:0008134 transcription factor binding
GO:0010463 mesenchymal cell proliferation
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0032502 developmental process
GO:0032991 protein-containing complex
GO:0034103 regulation of tissue remodeling
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042733 embryonic digit morphogenesis
GO:0042803 protein homodimerization activity
GO:0043392 negative regulation of DNA binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043586 tongue development
GO:0045668 negative regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048485 sympathetic nervous system development
GO:0048538 thymus development
GO:0048935 peripheral nervous system neuron development
GO:0060536 cartilage morphogenesis
GO:0060982 coronary artery morphogenesis
GO:0061032 visceral serous pericardium development
GO:0061309 cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061325 cell proliferation involved in outflow tract morphogenesis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070888 E-box binding
GO:1900745 positive regulation of p38MAPK cascade
GO:1903929 primary palate development
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000679 positive regulation of transcription regulatory region DNA binding
GO:2000763 positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process
GO:2000764 positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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