Entity Details

Primary name MSHR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ01726
EntryNameMSHR_HUMAN
FullNameMelanocyte-stimulating hormone receptor
TaxID9606
Evidenceevidence at protein level
Length317
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesMC1R

GO terms

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GOName
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004930 G protein-coupled receptor activity
GO:0004977 melanocortin receptor activity
GO:0004980 melanocyte-stimulating hormone receptor activity
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007275 multicellular organism development
GO:0008528 G protein-coupled peptide receptor activity
GO:0009650 UV protection
GO:0010739 positive regulation of protein kinase A signaling
GO:0019222 regulation of metabolic process
GO:0031625 ubiquitin protein ligase binding
GO:0032720 negative regulation of tumor necrosis factor production
GO:0035556 intracellular signal transduction
GO:0043473 pigmentation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051897 positive regulation of protein kinase B signaling
GO:0070914 UV-damage excision repair
GO:0090037 positive regulation of protein kinase C signaling

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000761 Melanocyte-stimulating hormone receptorFamilyFamily
IPR001671 Melanocortin/ACTH receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Disease IDSourceNameDescription
613099 OMIMMelanoma, cutaneous malignant 5 (CMM5)A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB04931 AfamelanotideDrugbanksmall molecule
DB05479 CZEN 002Drugbanksmall molecule
DB11653 BremelanotideDrugbanksmall molecule