Entity Details

Primary name SC6A3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ01959
EntryNameSC6A3_HUMAN
FullNameSodium-dependent dopamine transporter
TaxID9606
Evidenceevidence at protein level
Length620
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesSLC6A3

GO terms

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GOName
GO:0002020 protease binding
GO:0005102 signaling receptor binding
GO:0005326 neurotransmitter transmembrane transporter activity
GO:0005330 dopamine:sodium symporter activity
GO:0005334 norepinephrine:sodium symporter activity
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006836 neurotransmitter transport
GO:0007568 aging
GO:0007595 lactation
GO:0007608 sensory perception of smell
GO:0007626 locomotory behavior
GO:0008504 monoamine transmembrane transporter activity
GO:0009986 cell surface
GO:0010039 response to iron ion
GO:0015844 monoamine transport
GO:0015872 dopamine transport
GO:0015874 norepinephrine transport
GO:0016021 integral component of membrane
GO:0016600 flotillin complex
GO:0021984 adenohypophysis development
GO:0030424 axon
GO:0032809 neuronal cell body membrane
GO:0035094 response to nicotine
GO:0035240 dopamine binding
GO:0035725 sodium ion transmembrane transport
GO:0040018 positive regulation of multicellular organism growth
GO:0042053 regulation of dopamine metabolic process
GO:0042136 neurotransmitter biosynthetic process
GO:0042220 response to cocaine
GO:0042416 dopamine biosynthetic process
GO:0042420 dopamine catabolic process
GO:0042493 response to drug
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045471 response to ethanol
GO:0046872 metal ion binding
GO:0047485 protein N-terminus binding
GO:0051583 dopamine uptake involved in synaptic transmission
GO:0051591 response to cAMP
GO:0051721 protein phosphatase 2A binding
GO:0060134 prepulse inhibition
GO:0090494 dopamine uptake
GO:0098691 dopaminergic synapse
GO:0099055 integral component of postsynaptic membrane
GO:0099056 integral component of presynaptic membrane
GO:1990384 hyaloid vascular plexus regression

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000175 Sodium:neurotransmitter symporterFamilyFamily
IPR002436 Sodium:neurotransmitter symporter, dopamineFamilyFamily
IPR037272 Sodium:neurotransmitter symporter superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00182 AmphetamineDrugbanksmall molecule
DB00191 PhentermineDrugbanksmall molecule
DB00245 BenzatropineDrugbanksmall molecule
DB00285 VenlafaxineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00422 MethylphenidateDrugbanksmall molecule
DB00454 MeperidineDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00476 DuloxetineDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00579 MazindolDrugbanksmall molecule
DB00721 ProcaineDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00745 ModafinilDrugbanksmall molecule
DB00830 PhenmetrazineDrugbanksmall molecule
DB00852 PseudoephedrineDrugbanksmall molecule
DB00865 BenzphetamineDrugbanksmall molecule
DB00907 CocaineDrugbanksmall molecule
DB00937 DiethylpropionDrugbanksmall molecule
DB00988 DopamineDrugbanksmall molecule
DB01104 SertralineDrugbanksmall molecule
DB01105 SibutramineDrugbanksmall molecule
DB01114 ChlorpheniramineDrugbanksmall molecule
DB01146 DiphenylpyralineDrugbanksmall molecule
DB01149 NefazodoneDrugbanksmall molecule
DB01156 BupropionDrugbanksmall molecule
DB01161 ChloroprocaineDrugbanksmall molecule
DB01175 EscitalopramDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01363 Ephedra sinica rootDrugbankbiotech
DB01442 MMDADrugbanksmall molecule
DB01454 MidomafetamineDrugbanksmall molecule
DB01463 FencamfaminDrugbanksmall molecule
DB01472 4-MethoxyamphetamineDrugbanksmall molecule
DB01576 DextroamphetamineDrugbanksmall molecule
DB01577 MetamfetamineDrugbanksmall molecule
DB03701 VanoxerineDrugbanksmall molecule
DB04821 NomifensineDrugbanksmall molecule
DB04947 AltropaneDrugbanksmall molecule
DB06148 MianserinDrugbanksmall molecule
DB06156 TesofensineDrugbanksmall molecule
DB06333 TrodusquemineDrugbanksmall molecule
DB06413 ArmodafinilDrugbanksmall molecule
DB06700 DesvenlafaxineDrugbanksmall molecule
DB06701 DexmethylphenidateDrugbanksmall molecule
DB08824 Ioflupane I-123Swissprotsmall molecule
DB09194 EtoperidoneDrugbanksmall molecule
DB12305 DasotralineDrugbanksmall molecule
DB14754 SolriamfetolDrugbanksmall molecule