Entity Details

Primary name PPARD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ03181
EntryNamePPARD_HUMAN
FullNamePeroxisome proliferator-activated receptor delta
TaxID9606
Evidenceevidence at protein level
Length441
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesPPARD

GO terms

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GOName
GO:0007566 embryo implantation
GO:0007507 heart development
GO:0008144 drug binding
GO:0019216 regulation of lipid metabolic process
GO:0033189 response to vitamin A
GO:0060612 adipose tissue development
GO:0097190 apoptotic signaling pathway
GO:0005634 nucleus
GO:0009749 response to glucose
GO:0015908 fatty acid transport
GO:0071222 cellular response to lipopolysaccharide
GO:0045684 positive regulation of epidermis development
GO:0051546 keratinocyte migration
GO:0004879 nuclear receptor activity
GO:0014842 regulation of skeletal muscle satellite cell proliferation
GO:1904659 glucose transmembrane transport
GO:2000288 positive regulation of myoblast proliferation
GO:0006091 generation of precursor metabolites and energy
GO:0014823 response to activity
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0030308 negative regulation of cell growth
GO:0045893 positive regulation of transcription, DNA-templated
GO:0071456 cellular response to hypoxia
GO:0001223 transcription coactivator binding
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006629 lipid metabolic process
GO:0008289 lipid binding
GO:0009755 hormone-mediated signaling pathway
GO:0045662 negative regulation of myoblast differentiation
GO:0006915 apoptotic process
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051059 NF-kappaB binding
GO:0070539 linoleic acid binding
GO:1990837 sequence-specific double-stranded DNA binding
GO:0008203 cholesterol metabolic process
GO:0008366 axon ensheathment
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0045600 positive regulation of fat cell differentiation
GO:0046321 positive regulation of fatty acid oxidation
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:0008283 cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0033993 response to lipid
GO:0006631 fatty acid metabolic process
GO:0006776 vitamin A metabolic process
GO:0045923 positive regulation of fatty acid metabolic process
GO:0003677 DNA binding
GO:0042060 wound healing
GO:0000785 chromatin
GO:0006006 glucose metabolic process
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0032966 negative regulation of collagen biosynthetic process
GO:0043066 negative regulation of apoptotic process
GO:0006029 proteoglycan metabolic process
GO:0010887 negative regulation of cholesterol storage
GO:0031589 cell-substrate adhesion
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046697 decidualization
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0050728 negative regulation of inflammatory response
GO:0008654 phospholipid biosynthetic process
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0006635 fatty acid beta-oxidation
GO:0009062 fatty acid catabolic process
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030154 cell differentiation
GO:0043415 positive regulation of skeletal muscle tissue regeneration
GO:0043616 keratinocyte proliferation
GO:0003700 DNA-binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0005654 nucleoplasm
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0014912 negative regulation of smooth muscle cell migration

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR003074 Peroxisome proliferator-activated receptorFamilyFamily
IPR003075 Peroxisome proliferator-activated receptor, betaFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00132 alpha-Linolenic acidDrugbanksmall molecule
DB00159 IcosapentDrugbanksmall molecule
DB00197 TroglitazoneDrugbanksmall molecule
DB00313 Valproic acidDrugbanksmall molecule
DB00374 TreprostinilDrugbanksmall molecule
DB00412 RosiglitazoneDrugbanksmall molecule
DB00605 SulindacDrugbanksmall molecule
DB01393 BezafibrateDrugbanksmall molecule
DB02746 Phthalic AcidDrugbanksmall molecule
DB03338 Heptyl glucosideDrugbanksmall molecule
DB04224 Oleic AcidDrugbanksmall molecule
DB04801 cis-Vaccenic acidDrugbanksmall molecule
DB05187 ElafibranorDrugbanksmall molecule
DB05188 KD3010Drugbanksmall molecule
DB05416 CardarineDrugbanksmall molecule
DB07070 (2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acidDrugbanksmall molecule
DB07691 2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acidDrugbanksmall molecule
DB07724 IndeglitazarDrugbanksmall molecule
DB08078 {4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acidDrugbanksmall molecule
DB09006 ClinofibrateDrugbanksmall molecule
DB09462 GlycerinDrugbanksmall molecule
DB13873 Fenofibric acidDrugbanksmall molecule
DB13961 Fish oilDrugbankbiotech

Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
PPARD_HUMANSMAD9_HUMANBioGRID, HPRD, MINT15231748 details
PPARD_HUMANKDM1A_HUMANBioGRID, MINT23455924 details
PPARD_HUMANANM3_HUMANBioGRID, MINT23455924 details
PPARD_HUMANSTAT3_HUMANBioGRID, IntAct25814554 details
PPARD_HUMANKR107_HUMANBioGRID, IntAct25416956 details
PPARD_HUMANZN837_HUMANBioGRID, IntAct32296183 details
PPARD_HUMANNCOA1_HUMANBioGRID, IntAct15001550 15604093 15888456 16930961 21775429 details
PPARD_HUMANPRGC1_HUMANBioGRID, IntAct19596656 21775429 details
PPARD_HUMANCBP_HUMANIntAct21775429 details
PPARD_HUMANNCOA2_HUMANBioGRID, IntAct16930961 21775429 details
PPARD_HUMANNCOR1_HUMANBioGRID, HPRD, IntAct11867749 11903058 15001550 21775429 details
PPARD_HUMANNR1H2_HUMANBioGRID, DIP15722453 details
PPARD_HUMANNR1H3_HUMANBioGRID, DIP15722453 details
PPARD_HUMANLMNA_HUMANIntAct32814053 details
PPARD_HUMANSPRE1_HUMANIntAct32814053 details
PPARD_HUMANHD_HUMANIntAct32814053 details
PPARD_HUMANGA45G_HUMANBioGRID, HPRD10872826 details
PPARD_HUMANHDAC4_HUMANBioGRID12943985 details
PPARD_HUMANHDAC3_HUMANBioGRID, HPRD11867749 12943985 details
PPARD_HUMANNCOR2_HUMANBioGRID, HPRD11867749 15001550 details
PPARD_HUMANHDAC1_HUMANBioGRID, HPRD11867749 18037904 details
PPARD_HUMANEP300_HUMANBioGRID, HPRD10567538 16930961 18797151 details
PPARD_HUMANGLNA_HUMANBioGRID15604093 details
PPARD_HUMANITB5_HUMANBioGRID15604093 details
PPARD_HUMANPROX1_HUMANBioGRID, HPRD15604093 details
PPARD_HUMANRXRA_HUMANBioGRID, HPRD15604093 15888456 19756148 22205725 details
PPARD_HUMANPRDX6_HUMANBioGRID, HPRD15604093 details
PPARD_HUMANGLYM_HUMANBioGRID15604093 details
PPARD_HUMANRANB9_HUMANBioGRID, HPRD15604093 details
PPARD_HUMANRXRG_HUMANBioGRID, HPRD15604093 22205725 details
PPARD_HUMANNR0B2_HUMANBioGRID, HPRD15604093 details
PPARD_HUMANRXRB_HUMANBioGRID, HPRD15604093 22205725 details
PPARD_HUMANHS90A_HUMANBioGRID12962497 22939624 details
PPARD_HUMANSTP1_HUMANBioGRID21967852 details
PPARD_HUMANKR103_HUMANBioGRID25416956 details
PPARD_HUMANNCOA3_HUMANBioGRID15001550 15888456 details
PPARD_HUMANCE350_HUMANBioGRID15615782 details
PPARD_HUMANPRS8_HUMANBioGRID15604093 details
PPARD_HUMANHS90B_HUMANIntAct22939624 details
PPARD_HUMANHDAC2_HUMANBioGRID, HPRD, IntAct11867749 25241761 details
PPARD_HUMANMINT_HUMANBioGRID, HPRD11867749 details
PPARD_HUMANPPARD_HUMANBioGRID, HPRD10198642 17803688 details
PPARD_HUMANTF65_HUMANBioGRID18037904 details
PPARD_HUMANPSMG1_HUMANBioGRID18793612 details
PPARD_HUMANSTAT1_HUMANBioGRID26504087 details
PPARD_HUMANVHL_HUMANBioGRID32589900 details
PPARD_HUMANGA45B_HUMANHPRD10872826 details
PPARD_HUMANSRC_HUMANHPRD15001550 details
PPARD_HUMANPEBP1_HUMANHPRD15001550 details
PPARD_HUMANNRIP1_HUMANHPRD15001550 details
PPARD_HUMANHDAC7_HUMANHPRD12970571 details
PPARD_HUMANDUT_HUMANHPRD8910358 details