Entity Details

Primary name MEF2C_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ06413
EntryNameMEF2C_HUMAN
FullNameMyocyte-specific enhancer factor 2C
TaxID9606
Evidenceevidence at protein level
Length473
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesMEF2C

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000165 MAPK cascade
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001568 blood vessel development
GO:0001649 osteoblast differentiation
GO:0001764 neuron migration
GO:0001782 B cell homeostasis
GO:0001947 heart looping
GO:0001958 endochondral ossification
GO:0001974 blood vessel remodeling
GO:0002062 chondrocyte differentiation
GO:0002467 germinal center formation
GO:0002634 regulation of germinal center formation
GO:0002931 response to ischemia
GO:0003138 primary heart field specification
GO:0003139 secondary heart field specification
GO:0003151 outflow tract morphogenesis
GO:0003185 sinoatrial valve morphogenesis
GO:0003211 cardiac ventricle formation
GO:0003677 DNA binding
GO:0003680 minor groove of adenine-thymine-rich DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0006959 humoral immune response
GO:0007399 nervous system development
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0007521 muscle cell fate determination
GO:0007611 learning or memory
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010694 positive regulation of alkaline phosphatase activity
GO:0014033 neural crest cell differentiation
GO:0014902 myotube differentiation
GO:0016528 sarcoplasm
GO:0016607 nuclear speck
GO:0030154 cell differentiation
GO:0030182 neuron differentiation
GO:0030220 platelet formation
GO:0030279 negative regulation of ossification
GO:0030318 melanocyte differentiation
GO:0030501 positive regulation of bone mineralization
GO:0030890 positive regulation of B cell proliferation
GO:0032991 protein-containing complex
GO:0035690 cellular response to drug
GO:0035984 cellular response to trichostatin A
GO:0042100 B cell proliferation
GO:0042826 histone deacetylase binding
GO:0043231 intracellular membrane-bounded organelle
GO:0043406 positive regulation of MAP kinase activity
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045652 regulation of megakaryocyte differentiation
GO:0045663 positive regulation of myoblast differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046928 regulation of neurotransmitter secretion
GO:0046982 protein heterodimerization activity
GO:0048167 regulation of synaptic plasticity
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0048666 neuron development
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0050853 B cell receptor signaling pathway
GO:0051145 smooth muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0051963 regulation of synapse assembly
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0055012 ventricular cardiac muscle cell differentiation
GO:0060025 regulation of synaptic activity
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060079 excitatory postsynaptic potential
GO:0060998 regulation of dendritic spine development
GO:0061333 renal tubule morphogenesis
GO:0071222 cellular response to lipopolysaccharide
GO:0071277 cellular response to calcium ion
GO:0071374 cellular response to parathyroid hormone stimulus
GO:0071498 cellular response to fluid shear stress
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072102 glomerulus morphogenesis
GO:0072160 nephron tubule epithelial cell differentiation
GO:0098794 postsynapse
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation
GO:1904753 negative regulation of vascular associated smooth muscle cell migration
GO:1905563 negative regulation of vascular endothelial cell proliferation
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000111 positive regulation of macrophage apoptotic process
GO:2000310 regulation of NMDA receptor activity
GO:2000311 regulation of AMPA receptor activity
GO:2000727 positive regulation of cardiac muscle cell differentiation
GO:2000987 positive regulation of behavioral fear response
GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis
GO:2001016 positive regulation of skeletal muscle cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR002100 Transcription factor, MADS-boxDomainDomain
IPR022102 Holliday junction regulator protein family C-terminalDomainDomain
IPR033896 MADS MEF2-likeDomainDomain
IPR036879 Transcription factor, MADS-box superfamilyFamilyHomologous superfamily

Diseases

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Interactions

43 interactions

InteractorPartnerSourcesPublicationsLink
MEF2C_HUMANHDAC4_HUMANBioGRID, HPRD, IntAct, MINT10523670 11279209 11486037 11504882 11792813 12709441 15743821 15964851 18332106 23752268 31040226 32296183 details
MEF2C_HUMANMK14_HUMANBioGRID, HPRD, IntAct10330143 10805738 20936779 9069290 9753748 details
MEF2C_HUMANCSN5_HUMANBioGRID, IntAct20936779 details
MEF2C_HUMANEPAS1_HUMANBioGRID, IntAct20936779 details
MEF2C_HUMANHDAC9_HUMANBioGRID, IntAct20211142 20936779 details
MEF2C_HUMANMK07_HUMANBioGRID, HPRD, IntAct20936779 9384584 9753748 details
MEF2C_HUMANSPTB2_HUMANBioGRID, IntAct20936779 details
MEF2C_HUMAN1433Z_HUMANBioGRID, IntAct20936779 details
MEF2C_HUMANPG12A_HUMANBioGRID, IntAct21988832 details
MEF2C_HUMANMYLK2_HUMANMINT21556048 details
MEF2C_HUMANEP300_HUMANBioGRID, HPRD, MINT21556048 9001254 details
MEF2C_HUMANHDAC5_HUMANBioGRID, HPRD, IntAct10737771 11279209 20211142 23752268 details
MEF2C_HUMANHDAC7_HUMANBioGRID, IntAct11279209 18463162 23752268 details
MEF2C_HUMANSP1_HUMANBioGRID, HPRD9748305 details
MEF2C_HUMANSOX18_HUMANBioGRID, HPRD11554755 details
MEF2C_HUMANSMAD2_HUMANBioGRID, HPRD11160896 details
MEF2C_HUMANTEAD1_HUMANBioGRID, HPRD12061776 12861002 details
MEF2C_HUMANMYOD1_HUMANBioGRID15743821 9418854 details
MEF2C_HUMANMYOG_HUMANBioGRID8548800 details
MEF2C_HUMANNCOA2_HUMANBioGRID, HPRD12130539 details
MEF2C_HUMANIFRD1_HUMANBioGRID15743821 details
MEF2C_HUMANASCL1_HUMANBioGRID8900141 details
MEF2C_HUMANUBC9_HUMANBioGRID15561718 details
MEF2C_HUMANMEF2C_HUMANBioGRID, HPRD11744164 12130539 details
MEF2C_HUMANVGLL4_HUMANHPRD15140898 details
MEF2C_HUMANTFCP2_HUMANIntAct20195357 details
MEF2C_HUMANRTN3_HUMANIntAct31413325 details
MEF2C_HUMANSYAC_HUMANIntAct31413325 details
MEF2C_HUMANZBT44_HUMANIntAct31413325 details
MEF2C_HUMANZN350_HUMANIntAct31413325 details
MEF2C_HUMANSMCE1_HUMANIntAct31413325 details
MEF2C_HUMANUBE3A_HUMANMINT31988313 details
MEF2C_HUMANTWST2_HUMANBioGRID, HPRD11809751 details
MEF2C_HUMANSIR1_HUMANBioGRID19553684 details
MEF2C_HUMANSKP2_HUMANBioGRID25733682 details
MEF2C_HUMANTULP3_HUMANBioGRID33187986 details
MEF2C_HUMANMEF2D_HUMANHPRD9858528 details
MEF2C_HUMANGATA4_HUMANHPRD10790371 details
MEF2C_HUMANVGLL2_HUMANHPRD12376544 details
MEF2C_HUMANCSK21_HUMANHPRD8663403 details
MEF2C_HUMANNOTC1_HUMANHPRD10082551 details
MEF2C_HUMANCDK1_HUMANHPRD16478538 details
MEF2C_HUMANCCNB1_HUMANHPRD16478538 details