Entity Details

Primary name DLX2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ07687
EntryNameDLX2_HUMAN
FullNameHomeobox protein DLX-2
TaxID9606
Evidenceevidence at protein level
Length328
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesDLX2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0003727 single-stranded RNA binding
GO:0005634 nucleus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007420 brain development
GO:0009954 proximal/distal pattern formation
GO:0021544 subpallium development
GO:0021766 hippocampus development
GO:0021772 olfactory bulb development
GO:0021879 forebrain neuron differentiation
GO:0021893 cerebral cortex GABAergic interneuron fate commitment
GO:0030154 cell differentiation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0045597 positive regulation of cell differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0046533 negative regulation of photoreceptor cell differentiation
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0048755 branching morphogenesis of a nerve
GO:0051216 cartilage development
GO:1902871 positive regulation of amacrine cell differentiation
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000047 Helix-turn-helix motifSiteConserved site
IPR001356 Homeobox domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site
IPR020479 Homeobox domain, metazoaDomainDomain
IPR022135 Distal-less-like homeobox protein, N-terminal domainDomainDomain

Diseases

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