Entity Details

Primary name PDE4C_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ08493
EntryNamePDE4C_HUMAN
FullNamecAMP-specific 3',5'-cyclic phosphodiesterase 4C
TaxID9606
Evidenceevidence at protein level
Length712
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesPDE4C

GO terms

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GOName
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005929 cilium
GO:0006198 cAMP catabolic process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm

Subcellular Location

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Subcellular Location
Cell projection

Domains

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DomainNameCategoryType
IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domainDomainDomain
IPR003607 HD/PDEase domainDomainDomain
IPR023088 3'5'-cyclic nucleotide phosphodiesteraseFamilyFamily
IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved siteSiteConserved site
IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamilyFamilyHomologous superfamily
IPR040844 Phosphodiesterase 4 upstream conserved regions (UCR)DomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule
DB00651 DyphyllineDrugbanksmall molecule
DB01088 IloprostDrugbanksmall molecule
DB01427 AmrinoneDrugbanksmall molecule
DB01656 RoflumilastDrugbanksmall molecule
DB01791 PiclamilastDrugbanksmall molecule
DB05219 CrisaboroleDrugbanksmall molecule
DB05266 IbudilastDrugbanksmall molecule
DB06246 ExisulindDrugbanksmall molecule
DB09283 TrapidilDrugbanksmall molecule